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Aberrant response to dexamethasone suppression test associated with inflammatory response in MDD patients

Ulery et al. | Nov 06, 2023

Aberrant response to dexamethasone suppression test associated with inflammatory response in MDD patients

Major depressive disorder (MDD) is a prevalent mood disorder. The direct causes and biological mechanisms of depression still elude understanding, though genetic factors have been implicated. This study looked to identify the mechanism behind the aberrant response to the dexamethasone suppression test (DST) displayed by MDD patients, in which they display a lack of cortisol suppression. Analysis revealed several pro-inflammatory genes that were significant and differentially expressed between affected and non-affected groups in response to the DST. Looking at ways to decrease the inflammatory response could have implications for treatment and may explain why some people treated for depression still display symptoms or may lead researchers to different classes of drugs for treatment.

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The impact of genetic analysis on the early detection of colorectal cancer

Agrawal et al. | Aug 24, 2023

The impact of genetic analysis on the early detection of colorectal cancer

Although the 5-year survival rate for colorectal cancer is below 10%, it increases to greater than 90% if it is diagnosed early. We hypothesized from our research that analyzing non-synonymous single nucleotide variants (SNVs) in a patient's exome sequence would be an indicator for high genetic risk of developing colorectal cancer.

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Rhythmic lyrics translation: Customizing a pre-trained language model using stacked fine-tuning

Chong et al. | May 01, 2023

Rhythmic lyrics translation: Customizing a pre-trained language model using stacked fine-tuning
Image credit: Pixabay

Neural machine translation (NMT) is a software that uses neural network techniques to translate text from one language to another. However, one of the most famous NMT models—Google Translate—failed to give an accurate English translation of a famous Korean nursery rhyme, "Airplane" (비행기). The authors fine-tuned a pre-trained model first with a dataset from the lyrics domain, and then with a smaller dataset containing the rhythmical properties, to teach the model to translate rhythmically accurate lyrics. This stacked fine-tuning method resulted in an NMT model that could maintain the rhythmical characteristics of lyrics during translation while single fine-tuned models failed to do so.

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Toxicity of aminomethylphosphonic acid via the Wnt signaling pathway as a novel mechanism

Zhuang et al. | Mar 08, 2023

Toxicity of aminomethylphosphonic acid via the Wnt signaling pathway as a novel mechanism
Image credit: Image credit: Dapur Melodi

The Wnt signaling pathway, known to coordinate important aspects of cellular homeostasis ranging from differentiation, proliferation, migration, and much more, is dysregulated in many human diseases. This study demonstrates that aminomethylphosphonic acid, which is the main metabolite found in the common herbicide Glyphosate, is toxic to planaria and capable of binding to canonical Wnt proteins.

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The relationship between macroinvertebrates, water quality, and the health of Stevens Creek

Li et al. | Aug 18, 2021

The relationship between macroinvertebrates, water quality, and the health of Stevens Creek

Stevens Creek, which flows through Santa Clara County in California, provides a crucial habitat for federally designated threatened steelhead trout, with a portion of the trout’s diet being dependent on the presence and abundance of macroinvertebrates that inhabit the creek. In this article, the authors investigate how the water chemistry within the creek was associated with the abundance and diversity of macroinvertebrates, and subsequently the creek’s health. They conduct qualitative analysis of macroinvertebrates and water quality to obtain a general understanding of the health of Stevens Creek.

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