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Cellular senescence plays a key role in aging cells and is attributed to a number of disease and pathology. These authors find that genetic editing of both RPS6KB1 and PPARGC1A revitalizes a human skin fibroblast cell line.

This manuscript explores the performance of five different machine learning models in classifying brain tumors from a dataset of MRI scans. The authors find that several of the models showed >90% accuracy. Thus, the authors suggest that machine learning models demonstrate potential for effective implementation in clinical settings, including as a diagnostic tool that can be used to complement the expertise of neuroradiologists.

The authors looked at using computer vision to evaluate the degree of exotropia in individuals with strabismus.

Elevated acetylcholinesterase (AChE) activity contributes to cognitive decline and neurodegenerative diseases such as Alzheimer’s, motivating the search for more effective inhibitors with better bioavailability. This study used computational methods to design novel, non-toxic AChE inhibitors.

This study analyzes genetic alterations and expression patterns of protein kinases involved in phagocytosis across multiple cancers using TCGA data.

Detecting cervical spondylosis using deep learning

The authors looked at how injuries sustained during water tubing, that require treatment at an emergency department, differ between males and females.

To address the limitations in predicting the severity of Atrial Septal Defect (ASD), here the authors utilized a fluid-filled chamber model to quantify the relationship between defect size and right atrial fluid output. The findings confirmed that larger ASD diameters result in a linear increase in fluid output, validating a cost-effective model that can improve clinical prognosis and treatment planning for heart failure risks.

The authors looked at how vocabulary is impacted in Alzheimer's disease and whether it could be used a predictor of disease onset.

The authors use blood smears from individuals with sickle cell disease to correlate sickle cell frequency with the occurrence of vaso-occlusive crises.