
The authors look at how different food types impact the ability of bacteria to produce electricity.
Read More...The effects of food type on mediator-less microbial fuel cell electricity output
The authors look at how different food types impact the ability of bacteria to produce electricity.
Read More...Phytochemical analysis of Annona Reticulata extract and an in-vitro study on its anti-proliferative effects
In this study, the authors investigate the anti-cancer effects of Annona Reticulata (Ramphal or custard apple) by testing whether its extract could inhibit HeLa cell viability.
Read More...Integrating microbial fuel cell with sedum green roof for stormwater retention and renewable energy generation
The authors looked at renewable energy generators and the ability to utilize green roofs as a solution to climate change.
Read More...Synthesis of a novel CCR1 antagonist for treatment of glioblastoma
Glioblastoma is a brain cancer caused by the presence of a fast-growing, malignant tumor in the brain. As of now, this cancer is universally lethal due to lack of efficacious treatment options. C-C chemokine receptor 1 (CCR1) is a G-protein coupled receptor that controls chemotaxis, the movement of cells in response to chemical stimuli. This research aims to synthesize potential CCR1 antagonists by coupling carboxylic acids with a triazole core. We synthesized these compounds using a simple carboxylic acid coupling and confirmed the identity of the final compounds using nuclear magnetic resonance (NMR) spectroscopy.
Read More...Phytochemical Analysis of Amaranthus spinosus Linn.: An in vitro Analysis
Mainstream cancer treatments, which include radiotherapy and chemotherapeutic drugs, are known to induce oxidative damage to healthy somatic cells due to the liberation of harmful free radicals. In order to avert this, physiological antioxidants must be complemented with external antioxidants. Here the authors performed a preliminary phytochemical screen to identify alkaloids, saponins, flavonoids, polyphenols, and tannins in all parts of the Amaranthus spinosus Linn. plant. This paper describes the preparation of this crude extract and assesses its antioxidant properties for potential use in complementary cancer treatment.
Read More...Comparing the Effects of Different Natural Products on Reducing Tumor Growth in a Drosophila Model
In this work, the authors compared the effects of common natural products, including sesame, cinnamon, garlic, moringa and turmeric on tumor growth in Drosophila eyes. The data showed that these natural products cannot be used to reduce tumor growth once it has completely formed. However, the data suggested that some natural products can reduce cancer cell growth when tumors are treated early.
Read More...High-throughput virtual screening of novel dihydropyrimidine monastrol analogs reveals robust structure-activity relationship to kinesin Eg5 binding thermodynamics
As cancer continues to take millions of lives worldwide, the need to create effective therapeutics for the disease persists. The kinesin Eg5 assembly motor protein is a promising target for cancer therapeutics as inhibition of this protein leads to cell cycle arrest. Monastrol, a small dihydropyrimidine-based molecule capable of inhibiting the kinesin Eg5 function, has attracted the attention of medicinal chemists with its potency, affinity, and specificity to the highly targeted loop5/α2/α3 allosteric binding pocket. In this work, we employed high-throughput virtual screening (HTVS) to identify potential small molecule Eg5 inhibitors from a designed set of novel dihydropyrimidine analogs structurally similar to monastrol.
Read More...Structure-activity relationship of berberine and G4 DNA reveals aromaticity’s effect on binding affinity
Berberine is a natural quaternary alkaloid that has anti-microbial and anti-cancer effects. This compound can bind to Guanine Quadruplex (G4) DNA secondary complexes to help inhibit cancer cell proliferation. In this study, the authors investigate whether incorporating large aromatic rings helps to stabilize berberine-G4 interactions.
Read More...Analysis of complement system gene expression and outcome across the subtypes of glioma
Here the authors sought to better understand glioma, cancer that occurs in the glial cells of the brain with gene expression profile analysis. They considered the expression of complement system genes across the transcriptional and IDH-mutational subtypes of low-grade glioma and glioblastoma. Based on their results of their differential gene expression analysis, they found that outcomes vary across different glioma subtypes, with evidence suggesting that categorization of the transcriptional subtypes could help inform treatment by providing an expectation for treatment responses.
Read More...An Aqueous Solution Containing Soluble Substances From PVC Char Has No Effect on the Rate of Transformation in E. coli Cells
PVC is a widely used plastic that poses harmful health hazards when burned. In this study, the authors ask whether or not burned PVC (PVC char) affects bacterial transformation.
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