![Evolution of Neuroplastin-65](/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBCZz09IiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--4bab581401df18b8e18786fadb0e1a72ba65a920/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJYW5CbkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--a3b53ba1a0f83efef18f6e75a8d4ce784384bee2/cremers.jpg)
Human intelligence is correlated with variation in the protein neuroplastin-65, which is encoded by the NPTN gene. The authors examine the evolution of this gene across different animal species.
Read More...Evolution of Neuroplastin-65
Human intelligence is correlated with variation in the protein neuroplastin-65, which is encoded by the NPTN gene. The authors examine the evolution of this gene across different animal species.
Read More...Using economic indicators to create an empirical model of inflation
Here, seeking to understand the correlation of 50 of the most important economic indicators with inflation, the authors used a rolling linear regression to identify indicators with the most significant correlation with the Month over Month Consumer Price Index Seasonally Adjusted (CPI). Ultimately the concluded that the average gasoline price, U.S. import price index, and 5-year market expected inflation had the most significant correlation with the CPI.
Read More...The precision of machine learning models at classifying autism spectrum disorder in adults
Autism spectrum disorder (ASD) is hard to correctly diagnose due to the very subjective nature of diagnosing it: behavior analysis. Due to this issue, we sought to find a machine learning-based method that diagnoses ASD without behavior analysis or helps reduce misdiagnosis.
Read More...Characterizing the association between hippocampal reactive astrogliosis, anhedonia-like behaviors, and neurogenesis in a monkey model of stress and antidepressant treatment
This study examined the effects of stress and selective serotonin reuptake inhibitors (SSRIs) on a measure of astrocyte reactivity in nonhuman primate (NHP) models of stress. Results showed that chronic separation stress in NHPs leads to increased signs of astrogliosis in the NHP hippocampus. The findings were consistent with the hypotheses that hippocampal astrogliosis is an important mechanism in stress-induced cognitive and behavioral deficits.
Read More...Modeling stearoyl-coenzyme A desaturase 1 inhibitors to ameliorate α-Syn cytotoxicity in Parkinson's disease
The authors use molecular modeling to test analogs of the stearoyl-coenzyme A desaturase 1 (SCD1) inhibitor MF-438 with implications for future development of Parkinson's disease therapeutics.
Read More...The Effect of Antioxidant Vitamins on Mustard Plants in a Hydrogen Peroxide-Induced Injury Model
In this study, the authors assess the antioxidant properties of vitamins A, C and E given to mustard plants after oxidative damage. This research shows an interesting comparison of the vitamins' effect on plant recovery and health.
Read More...Identification of a core set of model agnostic mRNA associated with nonalcoholic steatohepatitis (NASH)
In this study, the authors analyze gene expression datasets to determine if there is a core set of genes dysregulated during nonalcoholic steatohepatitis.
Read More...In silico modeling of emodin’s interactions with serine/threonine kinases and chitosan derivatives
Here, through protein-ligand docking, the authors investigated the effect of the interaction of emodin with serine/threonine kinases, a subclass of kinases that is overexpressed in many cancers, which is implicated in phosphorylation cascades. Through molecular dynamics theyfound that emodin forms favorable interactions with chitosan and chitosan PEG (polyethylene glycol) copolymers, which could aid in loading drugs into nanoparticles (NPs) for targeted delivery to cancerous tissue. Both polymers demonstrated reasonable entrapment efficiencies, which encourages experimental exploration of emodin through targeted drug delivery vehicles and their anticancer activity.
Read More...A novel deep learning model for visibility correction of environmental factors in autonomous vehicles
Intelligent vehicles utilize a combination of video-enabled object detection and radar data to traverse safely through surrounding environments. However, since the most momentary missteps in these systems can cause devastating collisions, the margin of error in the software for these systems is small. In this paper, we hypothesized that a novel object detection system that improves detection accuracy and speed of detection during adverse weather conditions would outperform industry alternatives in an average comparison.
Read More...A Novel Approach to Prevent and Restrict Early Stages of Cancer Cell Growth Using a Combination of Moringa and Sesame in a Drosophila Model
Sesame (Sesamum indicum) and moringa (Moringa oleifera) have natural antioxidants that could prevent cancer growth. Previously, this group found that sesame and moringa individually suppress eye tumor grown in the Drosophila melanogaster model. In the present study, combinations of sesame and moringa at different concentrations were included in the D. melanogaster diet. The impact on eye tumor development was assessed at different stages of growth.
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