The authors test the antiproliferative and apoptosis-inducing properties of an extract created from a traditional Indian medicinal plant of the Amaranthus genus.
Read More...Cytotoxicity evaluation of Amaranthus extracts compared with AS20 on MCF-7 cancer cells
The authors test the antiproliferative and apoptosis-inducing properties of an extract created from a traditional Indian medicinal plant of the Amaranthus genus.
Read More...Managing CO2 levels through precipitation-based capture from seawater and electrochemical conversion
The authors set out to develop an electrochemical device that would have efficient and sustained carbon dioxide capture.
Read More...Contrasting role of ASCC3 and ALKBH3 in determining genomic alterations in Glioblastoma Multiforme
Glioblastoma Multiforme (GBM) is the most malignant brain tumor with the highest fraction of genome alterations (FGA), manifesting poor disease-free status (DFS) and overall survival (OS). We explored The Cancer Genome Atlas (TCGA) and cBioportal public dataset- Firehose legacy GBM to study DNA repair genes Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) and Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3 (ALKBH3). To test our hypothesis that these genes have correlations with FGA and can better determine prognosis and survival, we sorted the dataset to arrive at 254 patients. Analyzing using RStudio, both ASCC3 and ALKBH3 demonstrated hypomethylation in 82.3% and 61.8% of patients, respectively. Interestingly, low mRNA expression was observed in both these genes. We further conducted correlation tests between both methylation and mRNA expression of these genes with FGA. ASCC3 was found to be negatively correlated, while ALKBH3 was found to be positively correlated, potentially indicating contrasting dysregulation of these two genes. Prognostic analysis showed the following: ASCC3 hypomethylation is significant with DFS and high ASCC3 mRNA expression to be significant with OS, demonstrating ASCC3’s potential as disease prediction marker.
Read More...Gene expression profiling of MERS-CoV-London strain
In this study, the authors identify transcripts and gene networks that are changed after infection with the Middle East Respiratory Syndrome-related coronavirus (MERS-CoV).
Read More...A novel filtration model for microplastics using natural oils and its application to the environment
Recognizing the need for a method to filter microplastics from polluted water the authors sought to use nonpolar solvents, palm oil and palm kernel oil, to filter microplastics out of model seawater. By relying on the separation of polar and nonpolar solvents followed by freezing the nonpolar solvent, they reported that microplastics could be extracted with percentages ranging from 96.2% to 94.2%. They also provided an estimation to use this method as part of container ships to clean the Pacific Ocean of microplastics.
Read More...Association of depression and suicidal ideation among adults with the use of H2 antagonists
In this study, the authors investigate associations between use of histamine H2 receptor antagonists and suicidal ideation in different age groups.
Read More...Using CRISPR technology to inhibit the replication of human cytomegalovirus by deletion of a gene promoter
Human cytomegalovirus (HCMV) causes serious infections in immunocompromised patients and therapies to inhibit latent HCMV are not developed. Using CRISPR/Cas9, the authors were able to delete an important promoter region in HCMV.
Read More...Novel biaryl imines and amines as potential competitive inhibitors of dihydropteroate synthase
In this study, the authors design a series of new biaryl small molecules to target and block the binding pocket of the enzyme dihydropteroate synthase, which is important for prokaryotic biosynthesis of folic acid and could serve as better antimicrobial compounds.
Read More...Understanding the movement of professional and high school soccer players
In this article, the authors use datasets of professional and youth soccer players' movements to map and statistically compare them. Analysis compared movements that led to goals or no-goals and differences between pros and youth.
Read More...Differences in Reliability and Predictability of Harvested Energy from Battery-less Intermittently Powered Systems
Solar and radio frequency harvesters serve as a viable alternative energy source to batteries in many cases where the battery cannot be easily replaced. Using specifically designed circuit models, the authors quantify the reliability of different harvested energy sources to identify the most practical and efficient forms of renewable energy.
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