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The authors found that treatment with AS20 suppressed phorbol 12-myristate 13-acetate (PMA) and 5-flurouracil (5-FU) induction of COX2 expression. We also observed AS20 treated cells showed DNA fragmentation in HeLa cells.

Berberine is a natural product isoquinoline alkaloid derived from plants of the genus Berberis. When exposed to photoirradiation, it produces singlet oxygen through photosensitization of triplet oxygen. Through qNMR analysis of ¹H NMR spectra gathered through kinetic experiments, we were able to track the generation of a product between singlet oxygen and alpha terpinene, allowing us to quantitatively measure the photosensitizing properties of our scaffolds.

Here, based on the identification of androgapholide as a potential therapeutic treatment against cancer, Alzheimer's disease, diabetes, and multiple sclerosis, due to its ability to inhibit a signaling pathway in immune system function, the authors sought ways to optimize the natural product human systems by manipulating its chemical structure. Through the semisynthesis of a natural product along with computational studies, the authors developed an understanding of the kinetic mechanisms of andrographolide and semisynthetic analogs in the context of Michael additions.

In this study, the authors address the concerns of heavy metal contamination in industrial and feedlot water waste. They test whether added probiotics are capable of taking up heavy metals in water to attenuate pollution.

This study examined how prescribed fires affect arthropods in riparian zones surrounding wetlands in north-central Florida. Researchers found that spider abundance remained largely unchanged, while springtail abundance initially decreased but rebounded substantially one month after burning, suggesting early recovery of the riparian food web.

The authors test the effect of petroleum-based and bio-based microplastics on the growth of two microalgae species.

The authors looked at genes that were differentially expressed in patients who had and had not had febrile seizures to determine what differences in gene expression existed.

Andrographolide, a natural compound with anti-inflammatory, antidepressant, and anti-cancer properties, can be chemically modified by adding an acetonide group to form andrographolide acetonide, which is more potent and acts as a pH-dependent prodrug. Researchers investigated the hydrolysis of this acetonide group under mildly acidic conditions.

The authors use known Parkinson's disease-associated genetic variants to compare the prevalence of sleep dysfunction between males and females diagnosed with Parkinson's disease.

The authors looked at the development of biodegradable bioplastic and its features compared to PET packaging films. They were able to develop a biodegradable plastic with sodium alginate that dissolved in water and degrade in microbial conditions while also being transparent and flexible similar to current plastic films.