![Using CRISPR technology to inhibit the replication of human cytomegalovirus by deletion of a gene promoter](/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBdUlKIiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--2b3f7be4957801a1da905dc6543cb4e40d8e0d29/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJYW5CbkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--a3b53ba1a0f83efef18f6e75a8d4ce784384bee2/CMV%20FIGURE%201%20REVISED.jpg)
Human cytomegalovirus (HCMV) causes serious infections in immunocompromised patients and therapies to inhibit latent HCMV are not developed. Using CRISPR/Cas9, the authors were able to delete an important promoter region in HCMV.
Read More...Using CRISPR technology to inhibit the replication of human cytomegalovirus by deletion of a gene promoter
Human cytomegalovirus (HCMV) causes serious infections in immunocompromised patients and therapies to inhibit latent HCMV are not developed. Using CRISPR/Cas9, the authors were able to delete an important promoter region in HCMV.
Read More...The novel function of PMS2 mutation on ovarian cancer proliferation
With disruption of DNA repair pathways pertinent to the timeline of cancer, thorough evaluation of mutations relevant to DNA repair proteins is crucial within cancer research. One such mutation includes S815L PMS2 - a mutation that results in significant decrease of DNA repair function by PMS2 protein. While mutation of PMS2 is associated with significantly increased colorectal and endometrial cancer risk, much work is left to do to establish the functional effects of the S815L PMS2 mutation in ovarian cancer progression. In this article, researchers contribute to this essential area of research by uncovering the tumor-progressive effects of the S815L PMS2 mutation in the context of ovarian cancer cell lines.
Read More...Long Range Radio Communication for Urban Sensor Networks
This study investigates the feasibility of using long-range radio communication in a busy city environment in order to begin better understanding how the Internet of Things might be implemented into smart cities.
Read More...Monitoring Local Soil Toxicity by Daphnia magna Viability
In this study a student uses Daphnia magna, or water fleas, to assay the purity of local soil samples. Daphnia magna are a helpful organism to detect potentially harmful levels of toxins in water.
Read More...The non-nutritive sweeteners acesulfame potassium and neotame slow the regeneration rate of planaria
The consumption of sugar substitute non-nutritive sweeteners (NNS) has dramatically increased in recent years. Despite being advertised as a healthy alternative, NNS have been linked to adverse effects on the body, such as neurodegenerative diseases (NDs). In NDs, neural stem cell function is impaired, which inhibits neuron regeneration. The purpose of this study was to determine if the NNS acesulfame potassium (Ace-K) and neotame affect planaria neuron regeneration rates. Since human neurons may regenerate, planaria, organisms with extensive regenerative capabilities due to stem cells called neoblasts, were used as the model organism. The heads of planaria exposed to either a control or non-toxic concentrations of NNS were amputated. The posterior regions of the planaria were observed every 24 hours to see the following regeneration stages: (1) wound healing, (2) blastema development, (3) growth, and (4) differentiation. The authors hypothesized that exposure to the NNS would slow planaria regeneration rates. The time it took for the planaria in the Ace-K group and the neotame group to reach the second, third, and fourth regeneration stage was significantly greater than that of the control. The results of this study indicated that exposure to the NNS significantly slowed regeneration rates in planaria. This suggests that the NNS may adversely impact neoblast proliferation rates in planaria, implying that it could impair neural stem cell proliferation in humans, which plays a role in NDs. This study may provide insight into the connection between NNS, human neuron regeneration, and NDs.
Read More...The Tendency of Teenagers to be Conformists and Follow the Crowd
Social psychologist Solomon Asch designed conformity tests to study how peer pressure from a group can influence an individual's own perception and behavior. In this study, students evaluate conformity behavior in a teenage group.
Read More...Effects of various alkaline carbonic solutions on the growth of the freshwater algae Chlorophyceae
Modern day fossil fuels are prone to polluting our environment, which can provide major habitat loss to many animals in our ecosystems. Algae-based biofuels have become an increasingly popular alternative to fossil fuels because of their sustainability, effectiveness, and environmentally-friendly nature. To encourage algae growth and solidify its role as an emerging biofuel, we tested basic (in terms of pH) solutions on pond water to determine which solution is most efficient in inducing the growth of algae.
Read More...Post-Traumatic Stress Disorder (PTSD) biomarker identification using a deep learning model
In this study, a deep learning model is used to classify post-traumatic stress disorder patients through novel markers to assist in finding candidate biomarkers for the disorder.
Read More...Impact of aluminum surface area on the rate of reaction with aqueous copper (II) chloride solutions
In this article the authors looked at how temperature was impacted when alumnium was added in various forms to aqueous copper(II) solutions. Their study investigates the impact of surface area on chemical reactions.
Read More...The Effect of Neem on Common Nosocomial Infection-Causing Organisms
Nosocomial infections acquired in hospitals pose a risk to patients, a risk compounded by resistant microorganisms. To combat this problem, researchers have turned to bioactive compounds from medicinal plants such as the widely used neem. In the present study, researchers sought to determine the effectiveness of different neem preparations against several hospital acquired human pathogens. Neem powder in water successfully inhibited microorganism growth making it a potential agent to combat these infections.
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