The authors test whether basil can grow in a simulated Martian soil improved with a waste-based fertilizer called Milorganite.

Buildings, which are responsible for the majority of electricity consumption in cities like Dubai, are often exclusively reliant on electrical lighting even in the presence of daylight to meet the illumination requirements of the building. This inefficient use of lighting creates potential to further optimize the energy efficiency of buildings by complementing natural light with electrical lighting. Prior research has mostly used ballasts (variable resistors) to regulate the brightness of bulbs. There has been limited research pertaining to the use of pulse width modulation (PWM) and the use of ‘triodes for alternating current’ (TRIACs). PWM and TRIACs rapidly stop and restart the flow of current to the bulb thus saving energy whilst maintaining a constant illumination level of a space. We conducted experiments to investigate the feasibility of using TRIACs and PWM in regulating the brightness of bulbs. We also established the relationship between power and brightness within the experimental setups. Our results indicate that lighting systems can be regulated through these alternate methods and that there is potential to save up to 16% of energy used without affecting the overall lighting of a given space. Since most energy used in buildings is still produced through fossil fuels, energy savings from lighting systems could contribute towards a lower carbon footprint. Our study provides an innovative solution to conserve light energy in buildings during daytime.

Glioblastoma Multiforme (GBM) is the most malignant brain tumor with the highest fraction of genome alterations (FGA), manifesting poor disease-free status (DFS) and overall survival (OS). We explored The Cancer Genome Atlas (TCGA) and cBioportal public dataset- Firehose legacy GBM to study DNA repair genes Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) and Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3 (ALKBH3). To test our hypothesis that these genes have correlations with FGA and can better determine prognosis and survival, we sorted the dataset to arrive at 254 patients. Analyzing using RStudio, both ASCC3 and ALKBH3 demonstrated hypomethylation in 82.3% and 61.8% of patients, respectively. Interestingly, low mRNA expression was observed in both these genes. We further conducted correlation tests between both methylation and mRNA expression of these genes with FGA. ASCC3 was found to be negatively correlated, while ALKBH3 was found to be positively correlated, potentially indicating contrasting dysregulation of these two genes. Prognostic analysis showed the following: ASCC3 hypomethylation is significant with DFS and high ASCC3 mRNA expression to be significant with OS, demonstrating ASCC3’s potential as disease prediction marker.

In this article, the authors systematically study whether the type of a star is correlated with the number of planets it can support. Their study shows that medium-sized stars are likely to support more than one planet, just like the case in our solar system. They predict that, of the hundreds of planets beyond our solar system, 6% might be habitable. As humans work to travel further and further into space, some of those might truly be suited for human life.

In this study, the authors address the concerns of heavy metal contamination in industrial and feedlot water waste. They test whether added probiotics are capable of taking up heavy metals in water to attenuate pollution.

We systematically evaluated the effects of raw material composition, heat treatment, and mechanical properties on 13-8PH stainless steel alloy. The results of the neural network models were in agreement with experimental results and aided in the evaluation of the effects of aging temperature on double shear strength. The data suggests that this model can be used to determine the appropriate 13-8PH alloy aging temperature needed to achieve the desired mechanical properties, eliminating the need for many costly trials and errors through re-heat treatments.

Recurrent neural networks (RNNs) are useful for text generation since they can generate outputs in the context of previous ones. Baroque music and language are similar, as every word or note exists in context with others, and they both follow strict rules. The authors hypothesized that if we represent music in a text format, an RNN designed to generate language could train on it and create music structurally similar to Bach’s. They found that the music generated by our RNN shared a similar structure with Bach’s music in the input dataset, while Bachbot’s outputs are significantly different from this experiment’s outputs and thus are less similar to Bach’s repertoire compared to our algorithm.

Lipases are a common class of enzymes that catalyze the breakdown of lipids. Here the authors characterize the the activity of pancreatic lipase in different organic solvents using a choloremetric assay, as well as using molecular dynamic simulations. They report that the activity of pancreatic lipase in 5% methanol is more than 25% higher than in water, despite enzyme stability being comparable in both solvents. This suggests that, for industrial applications, using pancreatic lipase in 5% methanol solution might increase yield, compared to just water.

The consumption of sugar substitute non-nutritive sweeteners (NNS) has dramatically increased in recent years. Despite being advertised as a healthy alternative, NNS have been linked to adverse effects on the body, such as neurodegenerative diseases (NDs). In NDs, neural stem cell function is impaired, which inhibits neuron regeneration. The purpose of this study was to determine if the NNS acesulfame potassium (Ace-K) and neotame affect planaria neuron regeneration rates. Since human neurons may regenerate, planaria, organisms with extensive regenerative capabilities due to stem cells called neoblasts, were used as the model organism. The heads of planaria exposed to either a control or non-toxic concentrations of NNS were amputated. The posterior regions of the planaria were observed every 24 hours to see the following regeneration stages: (1) wound healing, (2) blastema development, (3) growth, and (4) differentiation. The authors hypothesized that exposure to the NNS would slow planaria regeneration rates. The time it took for the planaria in the Ace-K group and the neotame group to reach the second, third, and fourth regeneration stage was significantly greater than that of the control. The results of this study indicated that exposure to the NNS significantly slowed regeneration rates in planaria. This suggests that the NNS may adversely impact neoblast proliferation rates in planaria, implying that it could impair neural stem cell proliferation in humans, which plays a role in NDs. This study may provide insight into the connection between NNS, human neuron regeneration, and NDs.

Agenesis of the Corpus Callosum (ACC) is a birth defect where an infant’s corpus callosum, the structure linking the brain’s two hemispheres to allow interhemispheric communication, fails to develop in a typical manner during pregnancy. Existing research on the connection between ACC and epilepsy leaves significant gaps, due to the lack of focused investigation. One important gap is the degree to which ACC may impact the course of epilepsy treatment and outcomes. The present study was conducted to test the hypotheses that epilepsy is highly prevalent among individuals with ACC, and that those with both ACC and epilepsy have a lower response rate to anticonvulsant drugs than other patients treated with anticonvulsant drugs. A weighted average of epilepsy rates was calculated from a review of existing literature, which supported the hypothesis that epilepsy was more common among individuals with ACC (25.11%) than in the general population (1.2%). An empirical survey administered to 57 subjects or parents of subjects showed that rate of intractable epilepsy among study subjects with both ACC and epilepsy was substantially higher than the rate found in the general population, indicating that individuals with both conditions had a lower response rate to the anticonvulsant drugs. This study contributes novel results regarding the potential for concurrence of ACC and epilepsy to interfere with anticonvulsant drug treatment. We also discuss implications for how medical professionals may use the findings of this study to add depth to their treatment decisions.