![Determining the best convolutional neural network for identifying tuberculosis and pneumonia in chest x-rays](/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBbUFLIiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--82a9bf00f146ac0ff43bda4e56ecaab0f4605cca/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJY0c1bkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--33b2b080106a274a4ca568f8742d366d42f20c14/Figure%201%20(2).png)
To best identify tuberculosis and pneumonia diagnoses in chest x-rays, the authors compare different deep learning convolution neural networks.
Read More...Determining the best convolutional neural network for identifying tuberculosis and pneumonia in chest x-rays
To best identify tuberculosis and pneumonia diagnoses in chest x-rays, the authors compare different deep learning convolution neural networks.
Read More...High-throughput virtual screening of novel dihydropyrimidine monastrol analogs reveals robust structure-activity relationship to kinesin Eg5 binding thermodynamics
As cancer continues to take millions of lives worldwide, the need to create effective therapeutics for the disease persists. The kinesin Eg5 assembly motor protein is a promising target for cancer therapeutics as inhibition of this protein leads to cell cycle arrest. Monastrol, a small dihydropyrimidine-based molecule capable of inhibiting the kinesin Eg5 function, has attracted the attention of medicinal chemists with its potency, affinity, and specificity to the highly targeted loop5/α2/α3 allosteric binding pocket. In this work, we employed high-throughput virtual screening (HTVS) to identify potential small molecule Eg5 inhibitors from a designed set of novel dihydropyrimidine analogs structurally similar to monastrol.
Read More...Heavy metal and bacterial water filtration using Moringa oleifera and coconut shell-activated carbon
One-third of the world's people do not have access to clean drinking water. Nadella and Nadella tackle this issue by testing a low-cost filtration system for removing heavy metal and bacteria from water.
Read More...One-step photochemical crosslinking of native proteins is feasible in tyrosine-rich bovine serum albumin
In this study, the authors develop a new hydrogel using photochemical crosslinking with bovine serum albumin and methylene blue. They find that this new hydrogel has some useful applications!
Read More...The Effects of Vibrotactile Feedback on Task Performance in a 3D-printed Myoelectric Prosthetic Arm
Here the authors strive to remedy the financial and mechanical deficiencies in current prosthetics by building a simple, noninvasive vibratory sensory feedback system into an inexpensive constructed 3D-printed prosthetic arm. They find that this simple feedback system has the potential to enhance feedback performance at a less cost.
Read More...Covalently Entrapping Catalase into Calcium Alginate Worm Pieces Using EDC Carbodiimide as a Crosslinker.
Catalase is a biocatalyst used to break down toxic hydrogen peroxide into water and oxygen in industries such as cheese and textiles. Improving the efficiency of catalase would help us to make some industrial products, such as cheese, less expensively. The best way to maintain catalase’s conformation, and thus enhance its activity, is to immobilize it. The primary goal of this study was to find a new way of immobilizing catalase.
Read More...Societal awareness regarding viral Hepatitis in developed and developing countries
Many cases of viral hepatitis are easily preventable if caught early; however, a lack of public awareness regarding often leads to diagnoses near the final stages of disease when it is most lethal. Thus, we wanted to understand to what extent an individual's sex, age, education and country of residence (India or Singapore) impacts disease identification. We sent out a survey and quiz to residents in India (n = 239) and Singapore (n = 130) with questions that test their knowledge and awareness of the disease. We hypothesized that older and more educated individuals would score higher because they are more experienced, but that the Indian population will not be as knowledgeable as the Singaporean population because they do not have as many resources, such as socioeconomic access to schools and accessibility to healthcare, available to them. Additionally, we predicted that there would not be any notable differences between make and females. The results revealed that the accuracy for all groups we looked at was primarily below 50%, demonstrating a severe knowledge gap. Therefore, we concluded that if more medical professionals discussed viral hepatitis during hospital visits and in schools, patients can avoid the end stages of the disease in notable cases.
Read More...Accessibility to urgent care services for disadvantaged populations: An analysis of healthcare disparities
The COVID-19 pandemic demonstrated the depth and significance of healthcare inequality in the United States. Xiao, Xiao, and Gong examine healthcare disparities in the Richmond (Virginia) metropolitan area by analyzing whether people from disadvantaged populations must travel for longer to reach healthcare facilities.
Read More...How has California’s Shelter-in-Place Order due to COVID-19 and the Resulting Reduction in Human Activity Affected Air and Water Quality?
As the world struggled to grapple with the emerging COVID-19 pandemic in 2020, many countries instated policies to help minimize the spread of the virus among residents. This inadvertently led to a decrease in travel, and in some cases, industrial output, two major sources of pollutants in today's world. Here, the authors investigate whether California's shelter-in-place policy was associated with a measurable decrease in water and air pollution in that state between June and July of 2020, compared to the preceeding five years. Their findings suggest that, by some metrics, air quality improved within certain areas while water quality was relatively unchanged. Overall, these findings suggest that changing human behavior can, indeed, help reduce the level of air pollutants that compromise air quality.
Read More...Investigation of Everyday Locations for Antibiotic-Resistant Bacteria in Cambridge, Massachusetts
In this study, the authors investigate whether antibiotic-resistant bacteria can be found in everyday locations. To do this, they collected samples from multiple high-trafficked areas in Cambridge, MA and grew them in the presence and absence of antibiotics. Interestingly, they grew bacterial colonies from many locations' samples, but not all could grow in the presence of ampicillin. These findings are intriguing and relevant given the rising concern about antibiotic-resistant bacteria.
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