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Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1

Jang et al. | Aug 19, 2016

Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1

Polo-like kinase 1 (Plk1) is a master regulator of mitosis, initiating key steps of cell cycle regulation, and its overexpression is associated with certain types of cancer. In this study, the authors carefully designed peptides that were able to bind to Plk1 at a location that is important for its proper localization and function. Future studies could further develop these peptides to selectively target Plk1 in cancer cells and induce mitotic arrest.

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Towards an Integrated Solution for Renewable Water and Energy

Chen et al. | Jan 09, 2015

Towards an Integrated Solution for Renewable Water and Energy

An integrated plant that would generate energy from solar power and provide clean water would help solve multiple sustainability issues. The feasibility of such a plant was investigated by looking at the efficacy of several different modules of such a plant on a small scale.

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Determining the Habitable Zone Around a Star

Lee et al. | May 29, 2013

Determining the Habitable Zone Around a Star

Life requires many things, including a hospitable temperature, elements, and energy. Here the authors utilize Newton's laws of physics and information relating a star's luminosity and temperature to determine the minimum and maximum masses and luminosities of planets and stars that would support life as we know it. This work can be used to determine the likelihood of a planet being able to support life based on attributes we can measure from here on Earth.

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Unveiling the wound healing potential of umbilical cord derived conditioned medium: an in vitro study

Vasal et al. | Jun 17, 2024

Unveiling the wound healing potential of umbilical cord derived conditioned medium: an <em>in vitro</em> study

Chronic wounds pose a serious threat to an individual’s health and quality of life. However, due to the severity and morbidity of such wounds, many pre-existing treatments are inefficient or costly. While the use of skin grafts and other such biological constructs in chronic wound healing has already been characterized, the use of umbilical cord tissue has only recently garnered interest, despite the cytokine-rich composition of Wharton’s jelly (cord component). Our current study aimed to characterize the use of an umbilical cord derived conditioned medium (UC-CM) to treat chronic wounds.

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Locating sources of a high energy cosmic ray extensive air shower using HiSPARC data

Aziz et al. | Oct 24, 2023

Locating sources of a high energy cosmic ray extensive air shower using HiSPARC data

Using the data provided by the University of Twente High School Project on Astrophysics Research with Cosmics (HiSPARC), an analysis of locations for possible high-energy cosmic ray air showers was conducted. An example includes an analysis conducted of the high-energy rain shower recorded in January 2014 and the use of Stellarium™ to discern its location.

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Developing novel plant waste-based hydrogels for skin regeneration and infection detection in diabetic wounds

Mathew et al. | Aug 10, 2023

Developing novel plant waste-based hydrogels for skin regeneration and infection detection in diabetic wounds

The purpose of this investigation is to develop a hydrogel to aid skin regeneration by creating an extracellular matrix for fibroblast growth with antibacterial and infection-detection properties. Authors developed two natural hydrogels based on pectin and potato peels and characterized the gels for fibroblast compatibility through rheology, scanning electron microscopy, swelling, degradation, and cell cytotoxicity assays. Overall, this experiment fabricated various hydrogels capable of acting as skin substitutes and counteracting infections to facilitate wound healing. Following further testing and validation, these hydrogels could help alleviate the 13-billion-dollar financial burden of foot ulcer treatment.

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Correlation of Prominent Intelligence Type & Coworker Relations

Rasmus et al. | Mar 29, 2022

Correlation of Prominent Intelligence Type & Coworker Relations

Ashley Moulton & Joseph Rasmus investigate 9 controversial categories of intelligence as predicted by Multiple Intelligence Theory, originally proposed in the mid-1980s. By collecting data from 56 participants, they record that there may not actually be a correlation between these categorical types when it comes to workplace atmosphere and project efficiency.

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