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Analysis of complement system gene expression and outcome across the subtypes of glioma

Mudda et al. | May 17, 2023

Analysis of complement system gene expression and outcome across the subtypes of glioma
Image credit: National Cancer Institute

Here the authors sought to better understand glioma, cancer that occurs in the glial cells of the brain with gene expression profile analysis. They considered the expression of complement system genes across the transcriptional and IDH-mutational subtypes of low-grade glioma and glioblastoma. Based on their results of their differential gene expression analysis, they found that outcomes vary across different glioma subtypes, with evidence suggesting that categorization of the transcriptional subtypes could help inform treatment by providing an expectation for treatment responses.

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Quantitative NMR spectroscopy reveals solvent effects in the photochemical degradation of thymoquinone

Mandava et al. | Dec 16, 2023

Quantitative NMR spectroscopy reveals solvent effects in the photochemical degradation of thymoquinone

Thymoquinone is a compound of great therapeutic potential and scientific interest. However, its clinical administration and synthetic modifications are greatly limited by its instability in the presence of light. This study employed quantitative 1H nuclear magnetic resonance (NMR) spectroscopy to identify the effect of solvation on the degradation of thymoquinone under ultraviolet light (UV). It found that the rate of degradation is highly solvent dependent occurs maximally in chloroform.

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Comparative screening of dose-dependent and strain-specific antimicrobial efficacy of berberine against a representative library of broad-spectrum antibiotics

Sun et al. | May 10, 2021

Comparative screening of dose-dependent and strain-specific antimicrobial efficacy of berberine against a representative library of broad-spectrum antibiotics

We hypothesize that berberine has broad-spectrum antibacterial properties, along with potency that is comparable to current broad-spectrum antibiotics that are commercially available. Here, we screened berberine against four strains of bacteria and evaluated its antimicrobial activity against five broad-spectrum antibiotics from different classes to better quantify berberine’s antibacterial activity and compare its efficacy as an antibacterial agent to the broad-spectrum antibiotics. Our results indicated that berberine had strain-selective cytotoxic effects and was significantly less potent than most of the broad-spectrum antibiotics

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The Effect of Cobalt Biomineralization on Power Density in a Microbial Fuel Cell

Bandyopadhyay et al. | Sep 07, 2015

The Effect of Cobalt Biomineralization on Power Density in a Microbial Fuel Cell

A microbial fuel cell is a system to produce electric current using biochemical products from bacteria. In this project authors operated a microbial fuel cell in which glucose was oxidized by Shewanella oneidensis in the anodic compartment. We compared the power output from biomineralized manganese or cobalt oxides, reduced by Leptothrix cholodnii in the cathodic compartment.

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Defying chemical tagging: inhomogeneities in the wide binary system HIP 34407/HIP 34426

Còdol et al. | Oct 05, 2023

Defying chemical tagging: inhomogeneities in the wide binary system HIP 34407/HIP 34426
Image credit: Pixabay

This assessed the hypothesis that stars in wide binary systems are chemically homogeneous because of their shared origin. Abundances of the HIP 34407/HIP 34426 binary were obtained by analyzing high-resolution spectra of the system. Discrepancies found in the system’s elemental abundances might be an indicator of the presence of rocky planets around this star. Thus, the differences found in chemical composition might demonstrate limitations in the assumptions of chemical tagging.

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Are Age and Sex Related to Emotion Recognition Ability in Children and Teenagers?

Gallego-García et al. | Feb 23, 2018

Are Age and Sex Related to Emotion Recognition Ability in Children and Teenagers?

Humans have a natural ability to recognize emotional cues from the facial expressions of others, as a crucial evolutionary trait to navigate social interactions. This ability likely develops through normal development and social experience, but it is unclear how much influence age and sex have in emotional facial recognition (EFR). In this study, the authors investigate EFR in children and teenagers, and look at whether accurate emotional recognition does occur more in males or females.

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Effect of Gram-positive bacteria on antibiotic resistance in Gram-negative bacteria

Willem et al. | Mar 12, 2024

Effect of Gram-positive bacteria on antibiotic resistance in Gram-negative bacteria

Antibiotics are one of the most common treatments for bacterial infections, but the emergence of antibiotic resistance is a major threat to the control of infectious diseases. Many factors contribute to the development of antibiotic resistance. One is bacterial conjugation from Gram-positive to Gram-negative bacteria where there is a transfer of resistance genes from Gram-positive to Gram-negative bacteria that could increase antibiotic resistance in the latter. In light of these observations, we decided to test whether Gram-negative bacteria that came into contact with Gram-positive bacteria had a higher resistance to the antimicrobial properties of spices than Gram-negative bacteria that did not come into contact with Gram-positive bacteria.

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