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Evaluating Biomarkers and Treatments for Acute Kidney Injury in a Zebrafish Model

Mathew et al. | Aug 11, 2019

Evaluating Biomarkers and Treatments for Acute Kidney Injury in a Zebrafish Model

Coronary Artery Disease (CAD) is the leading cause of death in the United States, and 81% of Acute Kidney Injury (AKI) patients in the renal fibrosis stage later develop CAD. In this study, Mathew and Joykutty aimed to create a cost-effective strategy to treat AKI and thus prevent CAD using a model of the zebrafish, Danio rerio. They first tested whether AKI is induced in Danio rerio upon exposure to environmental toxins, then evaluated nitrotyrosine as an early biomarker for toxin-induced AKI. Finally, they evaluated 4 treatments of renal fibrosis, the last stage of AKI, and found that the compound SB431542 was the most effective treatment (reduced fibrosis by 99.97%). Their approach to treating AKI patients, and potentially prevent CAD, is economically feasible for translation into the clinic in both developing and developed countries.

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The relationship between macroinvertebrates, water quality, and the health of Stevens Creek

Li et al. | Aug 18, 2021

The relationship between macroinvertebrates, water quality, and the health of Stevens Creek

Stevens Creek, which flows through Santa Clara County in California, provides a crucial habitat for federally designated threatened steelhead trout, with a portion of the trout’s diet being dependent on the presence and abundance of macroinvertebrates that inhabit the creek. In this article, the authors investigate how the water chemistry within the creek was associated with the abundance and diversity of macroinvertebrates, and subsequently the creek’s health. They conduct qualitative analysis of macroinvertebrates and water quality to obtain a general understanding of the health of Stevens Creek.

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Formation and sticking of air bubbles in water in d-block containers

Gupta et al. | Jun 21, 2021

Formation and sticking of air bubbles in water in d-block containers

Bubbles! In this study, the authors investigate the effects that different materials, temperature, and distance have on the formation of water bubbles on the surface of copper and steel. They calculated mathematical relations based on the outcomes to better understand whether interstitial hydrogen present in the d-block metals form hydrogen bonds with the water bubbles to account for the structural and mechanical stability.

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Interaction of light with water under clear and algal bloom conditions

Ramesh et al. | Feb 01, 2024

Interaction of light with water under clear and algal bloom conditions
Image credit: Liz Harrell

Here, recognizing the potential harmful effects of algal blooms, the authors used satellite images to detect algal blooms in water bodies in Wyoming based on their reflectance of near infrared light. They found that remote monitoring in this way may provide a useful tool in providing early warning and advisories to people who may live in close proximity.

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Buttermilk and baking soda increase pancake fluffiness by liberating carbon dioxide

Rojas et al. | Sep 18, 2022

Buttermilk and baking soda increase pancake fluffiness by liberating carbon dioxide

Here, seeking a better understanding of what determines the fluffiness of a pancake, the authors began by considering a chemical reaction that results in the production of carbon dioxide gas from recipe ingredients, specifically sodium bicarbonate or baking soda. The substitution of homemade buttermilk for milk and adding more baking soda was found to result in significantly fluffier pancakes.

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