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Testing the Effects of Salep Derived From the Tubers of Orchis mascula, Aloe vera, and Alpha-chymotrypsin on Wound Healing in Drosophila melanogaster Larvae

Halder et al. | Sep 09, 2019

Testing the Effects of Salep Derived From the Tubers of <em>Orchis mascula</em>, <em>Aloe vera</em>, and Alpha-chymotrypsin on Wound Healing in <em>Drosophila melanogaster</em> Larvae

Aloe vera and alpha-chymotrypsin have been used in are known for their various wound healing properties. Halder et al hypothesized that these treatments would enhance wound healing in Drosophila melanogaster larvae over 2 weeks by decreasing wound size more effectively compared to controls. The results of two of the treatment groups, Salep and Aloe vera, yielded wound sizes small enough to present a significant percent decrease when compared with the wound sizes of the control group. Their results show support that both Salep and Aloe vera were effective for enhancing wound healing in epithelial cells in D. melanogaster larvae.

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Molecular Alterations in a High-Fat Mouse Model Before the Onset of Diet–Induced Nonalcoholic Fatty Liver Disease

Lee et al. | Sep 20, 2016

Molecular Alterations in a High-Fat Mouse Model Before the Onset of Diet–Induced Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases worldwide, but there are few studied warning signs for early detection of the disease. Here, researchers study alterations that occur in a mouse model of NAFLD, which indicate the onset of NAFLD sooner. Earlier detection of diseases can lead to better prevention and treatment.

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The effects of Helianthus Annuus on Amyotrophic Lateral Sclerosis using Drosophila Melanogaster

Srinivasan et al. | Oct 13, 2022

The effects of <em>Helianthus Annuus</em> on Amyotrophic Lateral Sclerosis using <em>Drosophila Melanogaster</em>

Amyotrophic lateral sclerosis (ALS) affects nearly 200,000 people worldwide and there is currently no cure. The purpose of the study was to determine if Helianthus annuus seeds helped reduce nerve degeneration and increase locomotion using Drosophila melanogaster as the model organism. Through this experiment, we found a general trend suggesting that H. annuus helped increase the mobility of the D. melanogaster suggesting it could be a viable supplement for patients with ALS.

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Alloferon improves the growth performance and developmental time of mealworms (Tenebrio molitor)

Shon et al. | Oct 20, 2023

Alloferon improves the growth performance and developmental time of mealworms <em>(Tenebrio molitor)</em>

Mealworms (Tenebrio molitor) are important food sources for reptiles, birds, and other organisms, as well as for humans. However, the slow growth and low survival rate of mealworms cause problems for mass production. Since alloferon, a synthetic peptide, showed long-term immunological effects on mealworms, we hypothesized that alloferon would function as a growth promoter to maximize mealworm production. We discovered that the overall weight of the alloferon-containing gelatin diet group was 39.5-90% heavier, and the development time of the experimental group was shortened up to 20.6-39.6% than the control group.

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Synthesis of a novel CCR1 antagonist for treatment of glioblastoma

Jan et al. | May 05, 2021

Synthesis of a novel CCR1 antagonist for treatment of glioblastoma

Glioblastoma is a brain cancer caused by the presence of a fast-growing, malignant tumor in the brain. As of now, this cancer is universally lethal due to lack of efficacious treatment options. C-C chemokine receptor 1 (CCR1) is a G-protein coupled receptor that controls chemotaxis, the movement of cells in response to chemical stimuli. This research aims to synthesize potential CCR1 antagonists by coupling carboxylic acids with a triazole core. We synthesized these compounds using a simple carboxylic acid coupling and confirmed the identity of the final compounds using nuclear magnetic resonance (NMR) spectroscopy.

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Comparative Analysis of Vital Capacities of Athletes, Singers and Other Students of Age 13-14 Years: A Cross-Sectional Observational Study

Taneja et al. | Sep 30, 2019

Comparative Analysis of Vital Capacities of Athletes, Singers and Other Students of Age 13-14 Years: A Cross-Sectional Observational Study

Physical activity when performed regularly has beneficial effects on all systems of the body, including pulmonary functions. This study, conducted at Springdales School in Dhaula Kuan, New Delhi, aimed to determine the effect of sports and singing on the vital capacity (the maximum amount of air a person can expel from the lungs after a maximum inhalation), an important measure of pulmonary health.

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Phospholipase A2 increases the sensitivity of doxorubicin induced cell death in 3D breast cancer cell models

Lee et al. | Mar 30, 2022

Phospholipase A2 increases the sensitivity of doxorubicin induced cell death in 3D breast cancer cell models

Inefficient penetration of cancer drugs into the interior of the three-dimensional (3D) tumor tissue limits drugs' delivery. The authors hypothesized that the addition of phospholipase A2 (PLA2) would increase the permeability of the drug doxorubicin for efficient drug penetration. They found that 1 mM PLA2 had the highest permeability. Increased efficiency in drug delivery would allow lower concentrations of drugs to be used, minimizing damage to normal cells.

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Role of Environmental Conditions on Drying of Paint

Aggarwal et al. | Feb 20, 2021

Role of Environmental Conditions on Drying of Paint

Reducing paint drying time is an important step in improving production efficiency and reducing costs. The authors hypothesized that decreased humidity would lead to faster drying, ultraviolet (UV) light exposure would not affect the paint colors differently, white light exposure would allow for longer wavelength colors to dry at a faster rate than shorter wavelength colors, and substrates with higher roughness would dry slower. Experiments showed that trials under high humidity dried slightly faster than trials under low humidity, contrary to the hypothesis. Overall, the paint drying process is very much dependent on its surrounding environment, and optimizing the drying process requires a thorough understanding of the environmental factors and their interactive effects with the paint constituents.

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Linearity of piezoelectric response of electrospun polymer-based (PVDF) fibers with barium titanate nanoparticles

Nichitiu et al. | Feb 13, 2023

Linearity of piezoelectric response of electrospun polymer-based (PVDF) fibers with barium titanate nanoparticles

Here, seeking to develop an understanding of the properties that determine the viability of piezoelectric flexible materials for applications in electro-mechanical sensors, the authors investigated the effects of the inclusion BaTiO3 nanoparticles in electrospun Polyvinyledene Fluoride. They found the voltage generated had a piecewise linear dependence on the applied force at a few temperatures.

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