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Quantitative NMR spectroscopy reveals solvent effects in the photochemical degradation of thymoquinone

Mandava et al. | Dec 16, 2023

Quantitative NMR spectroscopy reveals solvent effects in the photochemical degradation of thymoquinone

Thymoquinone is a compound of great therapeutic potential and scientific interest. However, its clinical administration and synthetic modifications are greatly limited by its instability in the presence of light. This study employed quantitative 1H nuclear magnetic resonance (NMR) spectroscopy to identify the effect of solvation on the degradation of thymoquinone under ultraviolet light (UV). It found that the rate of degradation is highly solvent dependent occurs maximally in chloroform.

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The Effect of Ultraviolet Radiation and the Antioxidant Curcumin on the Longevity, Fertility, and Physical Structure of Drosophila melanogaster: Can We Defend Our DNA?

Lateef et al. | May 18, 2019

The Effect of Ultraviolet Radiation and the Antioxidant Curcumin on the Longevity, Fertility, and Physical Structure of <em>Drosophila melanogaster</em>: Can We Defend Our DNA?

Ultraviolet (UV) radiation is known to alter DNA structure and impair cellular function in all living organisms. In this study, Lateef et al examine the effects of UV radiation to determine whether antioxidant-enriched nutrition can combat the potential deleterious effects of UV radiation on Drosophila melanogaster. They found that UVB (320nm) radiation caused a 59% decrease in the Drosophila lifespan and mutagenic effects on flies' physical appearance, but did not significantly affect fertility. Curcumin significantly prolonged lifespan and enhanced fertility for both UV- and non-UV-exposed flies. The research demonstrates the positive potential of natural antioxidants as weapons against radiation-induced diseases including cancer.

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Assaying the Formation of Beneficial Biofilms by Lactic Acid Bacteria and the Effect of Ayurvedic Plant Extracts on Their Enhancement

Rajpal et al. | Oct 12, 2017

Assaying the Formation of Beneficial Biofilms by Lactic Acid Bacteria and the Effect of Ayurvedic Plant Extracts on Their Enhancement

This study aimed to obtain an optimal non-antibiotic method to suppress the growth of pathogenic bacteria within the body. The two-fold purpose of this project was to determine which combination of bacteria would result in the most biofilm formation and then to assess the effect of ayurvedic plant extracts on the biofilm. The results show that the addition of a plant extract can affect the biofilm growth of a bacteria combination. The applications of this study can be used to design probiotic supplements with added beneficial plant extracts.

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Testing the Effects of Resveratrol, Apigenin, and Glucosamine to Effectively Reduce Prostate Cancer Cell Proliferation, Migration Levels, and Increase Apoptosis

Yang et al. | Apr 16, 2020

Testing the Effects of Resveratrol, Apigenin, and Glucosamine to Effectively Reduce Prostate Cancer Cell Proliferation, Migration Levels, and Increase Apoptosis

The current five-year survival rate of metastasized prostate cancer is only 30% and occurs in every one in nine men. Researchers have shown that people with a type of dwarfism called Laron’s Syndrome are immune to cancer due to their low levels of insulin-like growth factor-1 (IGF-1). For this reason, experimentally modifying the level of IGF-1 could provide better insight into whether lowering the levels of IGF-1 in prostate cancer cell lines (e.g. PC-3) could be an effective treatment to reduce their rates of proliferation and migration and increase apoptosis. We selected three compounds, which researchers have shown decrease IGF-1 levels, to test and combine to determine which is the most promising.

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Can Green Tea Alleviate the Effects of Stress Related to Learning and Long-Term Memory in the Great Pond Snail (Lymnaea stagnalis)?

Elias et al. | Jan 30, 2021

Can Green Tea Alleviate the Effects of Stress Related to Learning and Long-Term Memory in the Great Pond Snail (<em>Lymnaea stagnalis</em>)?

Stress and anxiety have become more prevalent issues in recent years with teenagers especially at risk. Recent studies show that experiencing stress while learning can impair brain-cell communication thus negatively impacting learning. Green tea is believed to have the opposite effect, aiding in learning and memory retention. In this study, the authors used Lymnaea stagnalis , a pond snail, to explore the relationship between green tea and a stressor that impairs memory formation to determine the effects of both green tea and stress on the snails’ ability to learn, form, and retain memories. Using a conditioned taste aversion (CTA) assay, where snails are exposed to a sweet substance followed by a bitter taste with the number of biting responses being recorded, the authors found that stress was shown to be harmful to snail learning and memory for short-term, intermediate, and long-term memory.

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The Effect of Various Preparation Methods on the Spoilage Rate of Roma Tomatoes (Solanum lycopersicum)

Cataltepe et al. | Feb 22, 2018

The Effect of Various Preparation Methods on the Spoilage Rate of Roma Tomatoes (Solanum lycopersicum)

As levels of food waste continue to rise, it is essential to find improved techniques of prolonging the shelf life of produce. The authors aimed to find a simple, yet effective, method of slowing down spoilage in tomatoes. Linear regression analysis revealed that the tomatoes soaked salt water and not dried displayed the lowest correlation between time and spoilage, confirming that this preparation was the most effective.

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The Effect of Ethanol Concentration on Beta-Cell Development in Zebrafish

Payne et al. | Jan 15, 2014

The Effect of Ethanol Concentration on Beta-Cell Development in Zebrafish

Alcohol is known to cause various developmental diseases including Fetal Alcohol Syndrome. Here the authors investigate the effect of ethanol on the development of zebrafish beta cells, the part of the pancreas associated with Type 1 Diabetes. They find that exposure to ethanol does adversely affect beta-cell development, suggesting that alcohol ingestion during pregnancy may be linked to diabetes in newborns.

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Utilizing the Magnus effect to produce more downforce than a standard wing

Angiras et al. | Aug 15, 2022

Utilizing the Magnus effect to produce more downforce than a standard wing

Here, seeking a better solution to produce downforce that keeps a vehicle grounded at high speeds than wings which tend to result in degraded car performance due to increased air resistance, the authors considered using the Magnus effect as a replacement. The authors found that a spinning cylinder generated significantly more downforce through the Magnus effect than a standard wing at all wind speeds as simulated through the use of a leaf blower. They suggest that a cylinder could be a potential replacement for a wing when downforce is a priority.

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The knowledge and perception of opioid abuse and its long-term effects among high schoolers

Shroff et al. | Nov 27, 2021

The knowledge and perception of opioid abuse and its long-term effects among high schoolers

Due to the susceptibility of adolescent age groups to opioid misuse, here the authors sought to determine if there was a difference in the perception and knowledge between 9th and 12th graders regarding the opioid crisis. An educational intervention trial was done with the 9th graders and surveys were used to identify its effects. Although the authors acknowledge a small sample size, their results suggest that their are gaps within the knowledge of adolescents in regards to opioid misuse and its long-term effects that could be addressed with further education.

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