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The Role of a Mask - Understanding the Performance of Deep Neural Networks to Detect, Segment, and Extract Cellular Nuclei from Microscopy Images

Dasgupta et al. | Jul 06, 2021

The Role of a Mask - Understanding the Performance of Deep Neural Networks to Detect, Segment, and Extract Cellular Nuclei from Microscopy Images

Cell segmentation is the task of identifying cell nuclei instances in fluorescence microscopy images. The goal of this paper is to benchmark the performance of representative deep learning techniques for cell nuclei segmentation using standard datasets and common evaluation criteria. This research establishes an important baseline for cell nuclei segmentation, enabling researchers to continually refine and deploy neural models for real-world clinical applications.

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Strain-specific and photochemically-activated antimicrobial activity of berberine and two analogs

Sun et al. | Nov 17, 2020

Strain-specific and photochemically-activated antimicrobial activity of berberine and two analogs

In this study, the authors investigate the antimicrobial effects of berberine and berberine analogs. Berberine is extracted from plants and is a naturally occurring alkaloid, and is also excited photochemically. Using three different assays, the authors tested whether these compounds would inhibit bacterial growth. They found that these compounds were antibacterial and even more so when used with photoirradiation. This study has important antibacterial implications.

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In vitro Comparison of Anticancer and Immunomodulatory Activities of Resveratrol and its Oligomers

Zhang et al. | Sep 02, 2020

<em>In vitro</em> Comparison of Anticancer and Immunomodulatory Activities of Resveratrol and its Oligomers

Resveratrol is a type of stillbenoid, a phenolic compound produced in plants, that is known for its anti-inflammatory and anticancer effects. Many oligomers of resveratrol have recently been isolated their bioactivities remain unknown. Here, authors compared the bioactivities of resveratrol with natural dimers (ε-viniferin and gnetin H) and trimers (suffruticosol B and C). Results provide preliminary evidence that resveratrol oligomers could be potential preventive or therapeutic agents for cancers and other immune-related diseases

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Do Attractants Bias the Results of Malaise Trap Research?

Martinez et al. | Jan 22, 2020

Do Attractants Bias the Results of Malaise Trap Research?

Malaise traps are commonly used to collect flying insects for a variety of research. In this study, researchers hypothesized the attractants used in these traps may create bias in insect studies that could lead to misinterpreted data. To test this hypothesis two different kinds of attractant were used in malaise traps, and insect diversity was assessed. Attractants were found to alter the dispersion of insects caught in traps. These findings can inform future malaise traps studies on insect diversity.

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3D Printed Polymer Scaffolds for Bone Tissue Regeneration

Jayatissa et al. | Apr 26, 2019

3D Printed Polymer Scaffolds for Bone Tissue Regeneration

Scientists are always on the quest to improve the body's healing abilities and broken bones are no exception. In this article, the authors investigate properties of 3D-printed biocompatible polymers used to improve bone healing. With such efforts, we can hope to, one day, improve bone scaffolding materials in ways that make the natural healing processes more efficient, reducing the time needed for recovery from bone fractures.

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