![The effect of youth marijuana use on high-risk drug use: Examining gateway and substitution hypothesis](/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBZ1VSIiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--53a1be5279674679432deeb861f33f0ddc4515ee/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJY0c1bkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--33b2b080106a274a4ca568f8742d366d42f20c14/Figure%201.png)
The authors looked at whether youth use of marijuana related to later high-risk drug use. Using survey data from 2010-2019 they found that youth marijuana use did correlate to an increased risk of high-risk drug use.
Read More...The effect of youth marijuana use on high-risk drug use: Examining gateway and substitution hypothesis
The authors looked at whether youth use of marijuana related to later high-risk drug use. Using survey data from 2010-2019 they found that youth marijuana use did correlate to an increased risk of high-risk drug use.
Read More...Unveiling the wound healing potential of umbilical cord derived conditioned medium: an in vitro study
Chronic wounds pose a serious threat to an individual’s health and quality of life. However, due to the severity and morbidity of such wounds, many pre-existing treatments are inefficient or costly. While the use of skin grafts and other such biological constructs in chronic wound healing has already been characterized, the use of umbilical cord tissue has only recently garnered interest, despite the cytokine-rich composition of Wharton’s jelly (cord component). Our current study aimed to characterize the use of an umbilical cord derived conditioned medium (UC-CM) to treat chronic wounds.
Read More...Pressure and temperature influence the efficacy of metal-organic frameworks for carbon capture and conversion
Metal-organic frameworks (MOFs) are promising new nanomaterials for use in the fight against climate change that can efficiently capture and convert CO2 to other useful carbon products. This research used computational models to determine the reaction conditions under which MOFs can more efficiently capture and convert CO2. In a cost-efficient manner, this analysis tested the hypothesis that pressure and temperature affect the efficacy of carbon capture and conversion, and contribute to understanding the optimal conditions for MOF performance to improve the use of MOFs for controlling greenhouse CO2 emissions.
Read More...The role of CYP46A1 and its metabolic product, 24S-hydroxycholesterol, in Neuro 2A cell death
Cholesterol is a major component of neuronal cell membrane and myelin sheath. In this study, the authors either transfected Neuro 2A cells with CYP46A1 cDNA or treated the cells with 24SHC. Cells expressing CYP46A1 had significantly less viability compared to the negative control. Up to 55% reduction in cell viability was also observed in 24S-HC-treated cells. This work supports that CYP46A1 and 24S-HC could directly trigger cell death. The direct involvement of 24S-HC in cell death provides further evidence that 24S-HC can be a promising biomarker for diagnosing brain damage severity.
Read More...Impact of simple vs complex carbohydrates under time constraint before anaerobic and aerobic exercise
The goal of this study was to determine the if carbohydrates or complex carbohydrates are better for athlete's performance in anaerobic and aerobic exercise. Ultimately, we found that, when one’s schedule only allows for 30 minutes to eat before a workout, the best pre-workout meal for optimal glycogen levels to prompt muscle hypertrophy, strength increases, and better endurance is one that is simple carbohydrate-heavy.
Read More...Comparing model-centric and data-centric approaches to determine the efficiency of data-centric AI
In this study, three models are used to test the hypothesis that data-centric artificial intelligence (AI) will improve the performance of machine learning.
Read More...Substance Abuse Transmission-Impact of Parental Exposure to Nicotine/Alcohol on Regenerated Planaria Offspring
The global mental health crisis has led to increased substance abuse among youth. Prescription drug abuse causes approximately 115 American deaths daily. Understanding intergenerational transmission of substance abuse is complex due to lengthy human studies and socioeconomic variables. Recent FDA guidelines mandate abuse liability testing for neuro-active drugs but overlook intergenerational transfer. Brown planaria, due to their nervous system development similarities with mammals, offer a novel model.
Read More...Investigating the potential of zinc oxide nanoparticles and zinc ions as promising approaches to lung cancer
Here, the authors chose to investigate the efficacy of zinc oxide nanoparticles (ZnO NPs) and cisplatin or zinc ions in inducing cancer apoptosis. While both treatments were found to reduce the proliferation of lung cancer cells, the authors suggest that further studies to identify the mechanism are necessary.
Read More...Longer Exposure to 2% India Ink Increases Average Number of Vacuoles in Tetrahymena pyriformis
Phagocytes feed by forming food vacuoles. In this article the authors investigate the extent that exposure of non-nutritional food, such as India Ink, to Tetrahymena pyriformis affects the number of vacuole formation. These studies provide insight to how organisms budget their energy and metabolic processes during an energy shortage.
Read More...Increased carmine red exposure periods yields a higher number of vacuoles formed in Tetrahymena pyriformis
T. pyriformis can use phagocytosis to create vacuoles of carmine red, a dye which is made using crushed insects and is full of nutrients. Establishing a relationship between vacuole formation and duration of exposure to food can demonstrate how phagocytosis occurs in T. pyriformis. We hypothesized that if T. pyriformis was incubated in a carmine red solution, then more vacuoles would form over time in each cell.
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