The authors found that treatment with AS20 suppressed phorbol 12-myristate 13-acetate (PMA) and 5-flurouracil (5-FU) induction of COX2 expression. We also observed AS20 treated cells showed DNA fragmentation in HeLa cells.
Read More...Apoptosis induction and anti-inflammatory activity of polyherbal drug AS20 on cervical cancer cell lines
The authors found that treatment with AS20 suppressed phorbol 12-myristate 13-acetate (PMA) and 5-flurouracil (5-FU) induction of COX2 expression. We also observed AS20 treated cells showed DNA fragmentation in HeLa cells.
Read More...Conversion of Mesenchymal Stem Cells to Cancer-Associated Fibroblasts in a Tumor Microenvironment: An in vitro Study
Mesenchymal stem cells(MSCs) play a role in tumor formation by differentiating into cancer associated fibroblasts (CAFs) which enable metastasis of tumors. The process of conversion of MSCs into CAFs is not clear. In this study, authors tested the hypothesis that cancers cells secrete soluble factors that induce differentiation by culturing bone marrow mesenchymal stem cells in media conditioned by a breast cancer cell line.
Read More...A Quantitative Assessment of Time, Frequency, and Time-frequency Algorithms for Automated Seizure Detection and Monitoring
Each year, over 100,000 patients die from Sudden Unexpected Death in Epilepsy (SUDEP). A reliable seizure warning system can help patients stay safe. This work presents a comprehensive, comparative analysis of three different signal processing algorithms for automated seizure/ictal detection. The experimental results show that the proposed methods can be effective for accurate automated seizure detection and monitoring in clinical care.
Read More...How visualization influences strength endurance
Recognizing a potential link between mental focus and physical endurance, here, the authors considered the effects of mental visualization on strength endurance. By comparing the number of repetitions completed in sets where the lifter was aware of the weight to be lifted against sets where the lifter was kept unaware, they found that the lifter was able to maintain strength endurance when unable to accurately visualize the weight they lifted in this exploratory study.
Read More...The Perks of Watching a Movie: How the Portrayal of Anxiety and Depression in Film Affects Teenagers’ Perception of Anxiety and Depressive Disorders
In film, anxiety and depressive disorders are often depicted inaccurately. When viewers are exposed to these inaccurate portrayals, they collect misinformation about the disorders, as well as people who live with them, leading to stigma. This study used a mixed-method descriptive approach to analyze 16 teenagers’ attitudes towards people with anxiety and depression. Results found that while participants understood how these portrayals create stigma, they did not attribute this to misinformation. These results can be used to help both the film industry and the movie-going public better understand the effects of inaccurate storytelling and the extent to which it informs public perception
Read More...A Phylogenetic Study of Conifers Describes Their Evolutionary Relationships and Reveals Potential Explanations for Current Distribution Patterns
Many species of trees are distributed widely around the world, though not always in a way that makes immediate sense. The authors here use genetic information to help explain the geographic distribution of various conifer species throughout the world.
Read More...Comparing the Voltage Output of Water in Drop and Flow Form Using a Piezoelectric Sensor and Hydroelectric Turbine
This study compares the voltage output of two potential alternative energy sources: water drops hitting a piezoelectric surface and water flowing through a hydroelectric turbine. The findings of this study suggest that harnessing kinetic energy from falling raindrops may be a viable alternative energy source.
Read More...Racemic serine is less soluble than pure enantiomers due to stronger intermolecular hydrogen bonds
Seeking to develop a better understanding of the chemical and physical properties of amino acids that compose proteins, here the authors investigated the unusual relative insolubility of racemic mixtures of D- and L-serine compared to the solubility of pure D- or L-serine. The authors used a combination of microscopy and temperature measurements alongside previous X-ray diffraction studies to conclude that racemic DL-serine crystals consist of comparatively stronger hydrogen bond interactions compared to crystals of pure enantiomers. These stronger interactions were found to result in the unique release of heat during the crystallization of racemic mixtures.
Read More...The Impact of Antibiotic Exposure and Concentration on Resistance in Bacteria
Antibiotics are used to treat dangerous diseases. Over time, however, bacteria are becoming resistant to antibiotics - which poses a threat to humans and animals alike. In this paper, the authors examine how E. coli gains resistance to the antibiotic amoxicillin.
Read More...The Effects of Barley Straw (Hordeum vulgare) Extract and Barley Straw Pellets on Algal Growth and Water Quality
Algal overgrowth often threatens to clog irrigation pipes and drinking water lines when left unchecked, as well as releasing possible toxins that threaten plant and human health. It is thus important to find natural, non-harmful agents that can decrease algal growth without threatening the health of plants and humans. In this paper, the authors test the efficacy of barely extract in either liquid or pellet form in decreasing algal growth. While their results were inconclusive, the experimental set-up allows them to investigate a wider range of agents as anti-algal treatments that could potentially be adopted on a wider scale.
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