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Varying Growth Hormone Levels in Chondrocytes Increases Proliferation Rate and Collagen Production by a Direct Pathway

Bennett et al. | Sep 03, 2019

Varying Growth Hormone Levels in Chondrocytes Increases Proliferation Rate and Collagen Production by a Direct Pathway

Bennett and Joykutty test whether growth hormone directly or indirectly affected the rate at which cartilage renewed itself. Growth hormone could exert a direct effect on cartilage or chondrocytes by modifying the expression of different genes, whereas an indirect effect would come from growth hormone stimulating insulin-like growth factor. The results from this research support the hypothesis that growth hormone increases proliferation rate using the direct pathway. This research can be used in the medical sciences for people who suffer from joint damage and other cartilage-related diseases, since the results demonstrated conditions that lead to increased proliferation of chondrocytes. These combined results could be applied in a clinical setting with the goal of allowing patient cartilage to renew itself at a faster pace, therefore keeping those patients out of pain from these chondrocyte-related diseases.

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Societal awareness regarding viral Hepatitis in developed and developing countries

Srivastava et al. | Oct 03, 2022

Societal awareness regarding viral Hepatitis in developed and developing countries

Many cases of viral hepatitis are easily preventable if caught early; however, a lack of public awareness regarding often leads to diagnoses near the final stages of disease when it is most lethal. Thus, we wanted to understand to what extent an individual's sex, age, education and country of residence (India or Singapore) impacts disease identification. We sent out a survey and quiz to residents in India (n = 239) and Singapore (n = 130) with questions that test their knowledge and awareness of the disease. We hypothesized that older and more educated individuals would score higher because they are more experienced, but that the Indian population will not be as knowledgeable as the Singaporean population because they do not have as many resources, such as socioeconomic access to schools and accessibility to healthcare, available to them. Additionally, we predicted that there would not be any notable differences between make and females. The results revealed that the accuracy for all groups we looked at was primarily below 50%, demonstrating a severe knowledge gap. Therefore, we concluded that if more medical professionals discussed viral hepatitis during hospital visits and in schools, patients can avoid the end stages of the disease in notable cases.

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Association of agenesis of the corpus callosum with epilepsy and anticonvulsant drug treatment

Steger et al. | Feb 21, 2023

Association of agenesis of the corpus callosum with epilepsy and anticonvulsant drug treatment
Image credit: Robina Weermeijer on Unsplash

Agenesis of the Corpus Callosum (ACC) is a birth defect where an infant’s corpus callosum, the structure linking the brain’s two hemispheres to allow interhemispheric communication, fails to develop in a typical manner during pregnancy. Existing research on the connection between ACC and epilepsy leaves significant gaps, due to the lack of focused investigation. One important gap is the degree to which ACC may impact the course of epilepsy treatment and outcomes. The present study was conducted to test the hypotheses that epilepsy is highly prevalent among individuals with ACC, and that those with both ACC and epilepsy have a lower response rate to anticonvulsant drugs than other patients treated with anticonvulsant drugs. A weighted average of epilepsy rates was calculated from a review of existing literature, which supported the hypothesis that epilepsy was more common among individuals with ACC (25.11%) than in the general population (1.2%). An empirical survey administered to 57 subjects or parents of subjects showed that rate of intractable epilepsy among study subjects with both ACC and epilepsy was substantially higher than the rate found in the general population, indicating that individuals with both conditions had a lower response rate to the anticonvulsant drugs. This study contributes novel results regarding the potential for concurrence of ACC and epilepsy to interfere with anticonvulsant drug treatment. We also discuss implications for how medical professionals may use the findings of this study to add depth to their treatment decisions.

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The determinants and incentives of corporate greenhouse gas emission reduction

Liu et al. | Jun 04, 2021

The determinants and incentives of corporate greenhouse gas emission reduction

This study used hand-collected Greenhouse gas (GHG) emissions data from the Environmental Protection Agency (EPA) and aimed to understand the determinants and incentives of GHG emissions reduction. It explored how companies’ financials, Chief Executive Officer (CEO) compensation, and corporate governance affected GHG emissions. Results showed that companies reporting GHG emissions were wide-spread among the 48 industries represented by two-digit Standard Industrial Classification (SIC) codes.

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Similarity Graph-Based Semi-supervised Methods for Multiclass Data Classification

Balaji et al. | Sep 11, 2021

Similarity Graph-Based Semi-supervised Methods for Multiclass Data Classification

The purpose of the study was to determine whether graph-based machine learning techniques, which have increased prevalence in the last few years, can accurately classify data into one of many clusters, while requiring less labeled training data and parameter tuning as opposed to traditional machine learning algorithms. The results determined that the accuracy of graph-based and traditional classification algorithms depends directly upon the number of features of each dataset, the number of classes in each dataset, and the amount of labeled training data used.

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Determining the Effects of Voice Pitch on Adolescent Perception, Subconscious Bias, and Marketing Success Using Electroencephalography

Guan et al. | Apr 28, 2021

Determining the Effects of Voice Pitch on Adolescent Perception, Subconscious Bias, and Marketing Success Using Electroencephalography

Voice pitch affects perceived authoritativeness, competency, and leadership capacity. In this study, the authors suggest that examining certain measures of brain activity collected using an affordable EEG could predict advertising effectiveness, which may be invaluable in future neuromarketing research. Understanding voice pitch and other factors that cause implicit bias may allow significant advances in marketing, facilitating business success.

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Analysis of the effects of positive ions and boundary layer temperature at various hypersonic speeds on boundary layer density

Selvakumar et al. | Oct 02, 2020

Analysis of the effects of positive ions and boundary layer temperature at various hypersonic speeds on boundary layer density

This study's goal was to identify the Mach numbers for which electrostatic drag and heat transfer manipulation would be most applicable inside the stratosphere. The experiments were conducted using computational fluid dynamics software. The study demonstrated that, on average, higher Mach speeds resulted in a considerably higher potential decrease in density. The study highlights that further research on the surface charge method is warranted to explore higher hypersonic speeds within the stratosphere.

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