The authors looked at 5-FU resistant HeLa cells and the ability of an herbal extract to show anti-inflammatory properties.
Read More...The anticancer and anti-inflammatory effects of polyherbal drug AS20 on HeLa cells resistant to 5-Fluorouracil
The authors looked at 5-FU resistant HeLa cells and the ability of an herbal extract to show anti-inflammatory properties.
Read More...Modulation of Planaria Regeneration by Resolvin D1 and the Omega-3 Fatty Acid Precursor 17-Hydroxy Docosahexaenoic Acid
Omega-3 fatty acid derived lipid mediators have been implicated in resolving inflammation, and wound healing. Authors measured the impact of supplementation with lipid mediator Resolvin D1 and its precursor 17-HDHA on planaria regeneration. Planaria not only synthesize RvD1 from 17-DHA, but both RvD1 and 17-DHA enhanced regeneration.
Read More...Association of depression and suicidal ideation among adults with the use of H2 antagonists
In this study, the authors investigate associations between use of histamine H2 receptor antagonists and suicidal ideation in different age groups.
Read More...An Analysis on Exoplanets and How They are Affected by Different Factors in Their Star Systems
In this article, the authors systematically study whether the type of a star is correlated with the number of planets it can support. Their study shows that medium-sized stars are likely to support more than one planet, just like the case in our solar system. They predict that, of the hundreds of planets beyond our solar system, 6% might be habitable. As humans work to travel further and further into space, some of those might truly be suited for human life.
Read More...A study of South Korean international school students: Impact of COVID-19 on anxiety and learning habits
In this study, the authors investigate the effects of the COVID-19 pandemic on South Korean international school students' anxiety, well being and their learning habits.
Read More...Differences in the effect of copper sulfate on the mortality rate of Ostracod and Daphnia
Chemical pollution can have significant effects on freshwater organisms. In this study, the effect of copper sulfate on the survival of Daphnia pulex and Ostracoda was investigated.
Read More...Effects of airport runoff pollution on water quality in bay area sites near San Francisco and Oakland airports
In this study, the authors sample water at different points closer and closer to two different airports to determine if these airports may be contributing to water pollution, specifically by measuring metals, nitrates, and pH.
Read More...POC-MON: A Novel and Cost-Effective Pocket Lemon Sniff Test (PLST) for Early Detection of Major Depressive Disorder
Effective treatment of depression requires early detection. Depressive symptoms overlap with olfactory regions, which led to several studies of the correlation between sense of smell and depression. The alarming rise of depression, its related crimes, suicides, and lack of inexpensive, quick tools in detecting early depression — this study aims in demonstrating decreased olfaction and depression correlation. Forty-two subjects (ages 13-83) underwent POC-MON (Pocket Lemon) assessment — an oven-dried lemon peel sniff test, subjected to distance measurement when odor first detected (threshold) and completed Patient Health Questionnaires (PHQ-9). POC-MON and PHQ-9 scores yielded a correlation of 20% and 18% for the right and left nostrils, respectively. Among male (n=17) subjects, the average distance of POC-MON and PHQ-9 scores produced a correlation of 14% and 16% for the right and left nostrils, respectively. Females (n=25) demonstrated a correlation of 28% and 21% for the right and left nostrils, respectively. These results suggest the correlation between olfaction and depression in diagnosing its early-stage, using a quick, inexpensive, and patient-friendly tool — POC-MON.
Read More...Development of a novel machine learning platform to identify structural trends among NNRTI HIV-1 reverse transcriptase inhibitors
With advancements in machine learning a large data scale, high throughput virtual screening has become a more attractive method for screening drug candidates. This study compared the accuracy of molecular descriptors from two cheminformatics Mordred and PaDEL, software libraries, in characterizing the chemo-structural composition of 53 compounds from the non-nucleoside reverse transcriptase inhibitors (NNRTI) class. The classification model built with the filtered set of descriptors from Mordred was superior to the model using PaDEL descriptors. This approach can accelerate the identification of hit compounds and improve the efficiency of the drug discovery pipeline.
Read More...Effect of Manuka Honey and Licorice Root Extract on the Growth of Porphyromonas gingivalis: An In Vitro Study
Chronic bad breath, or halitosis, is a problem faced by nearly 50% of the general poluation, but existing treatments such as liquid mouthwash or sugar-free gum are imperfect and temporary solutions. In this study, the authors investigate potential alternative treatments using natural ingredients such as Manuka Honey and Licorice root extract. They found that Manuka honey is almost as effective as commercial mouthwashes in reducing the growth of P gingivalis (one of the main bacteria that causes bad breath), while Licorice root extract was largely ineffective. The authors' results suggest that Manuka honey is a promising candidate in the search for new and improved halitosis treatments.
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