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Testing Simarouba amara’s therapeutic effects against weedicide-induced tumor-like morphology in planarians

Thiagarajan et al. | Apr 26, 2024

Testing Simarouba amara’s therapeutic effects against weedicide-induced tumor-like morphology in planarians

According to the World Health Organization, cancer is a leading cause of death globally. The disease’s prevalence is rapidly increasing in association with factors including the increased use of pesticides and herbicides, such as glyphosate, which is one of the most widely used herbicide ingredients. Natural antioxidants and phytochemicals are being tested as anti-cancer agents due to their antiproliferative, antioxidative, and pro-apoptotic properties. Thus, we aimed to investigate the potential role of S. amara extract as a therapeutic agent against glyphosate-induced toxicity and tumor-like morphologies in regenerating and homeostatic planaria (Dugesia dorotocephala).

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Anonymity Reduces Generosity in High School Students

Vargas-Guerrero et al. | Nov 25, 2019

Anonymity Reduces Generosity in High School Students

The disinterested willingness a person has for helping others is known as altruism. But is this willingness to help others dependent on external factors that make you more or less inclined to be generous? We hypothesized that generosity in adolescents would depend on external factors and that these factors would change the amount of help given. To evaluate altruism and generosity, we conducted non-anonymous and anonymous variations of the dictator game and ultimatum game experiments and explored the role of anonymity, fairness, and reciprocity in high school students.

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Antibacterial effectiveness of turmeric against gram-positive Staphylococcus epidermidis

Cox et al. | Jan 10, 2022

Antibacterial effectiveness of turmeric against gram-positive <i>Staphylococcus epidermidis</i>

Infections caused by antibiotic resistance are a leading issue faced by the medical field. The authors studied the antibacterial effectiveness of turmeric against gram-positive Staphylococcus epidermidis using antibiotic sensitivity disks. They infused blank antibiotic sensitivity disks with a 5% concentrated solution of turmeric and placed them on agar plates inoculated with bacteria. Overall, there was no measurable ZOI surrounding the turmeric disk so the measurements for all trials were 0 cm, suggesting that turmeric at a 5% concentration is not an effective antibacterial against S. epidermidis.

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Efficacy of Rotten and Fresh Fruit Extracts as the Photosensitive Dye for Dye-Sensitized Solar Cells

Jayasankar et al. | Jan 16, 2019

Efficacy of Rotten and Fresh Fruit Extracts as the Photosensitive Dye for Dye-Sensitized Solar Cells

Dye-sensitized solar cells (DSSC) use dye as the photoactive material, which capture the incoming photon of light and use the energy to excite electrons. Research in DSSCs has centered around improving the efficacy of photosensitive dyes. A fruit's color is defined by a unique set of molecules, known as a pigment profile, which changes as a fruit progresses from ripe to rotten. This project investigates the use of fresh and rotten fruit extracts as the photoactive dye in a DSSC.

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The effects of different modes of vocalization and food consumption on the level of droplet transmission of bacteria

Wong et al. | May 10, 2021

The effects of different modes of vocalization and food consumption on the level of droplet transmission of bacteria

Microbial agents reposnsible for respiratory infections are often carried in spittle, which means they can be easily transmitted. Here, the authors investigate how likely certain activities are to spread microbes carried in spittle. They also investigate whether eating certain types of food might reduce the spread of spittle-borne bacteria too.

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Reducing Crop Damage Caused by Folsomia candida by Providing an Alternate Food Source

Tamura et al. | May 28, 2018

Reducing Crop Damage Caused by Folsomia candida by Providing an Alternate Food Source

Tamura and Moché found that Folsomia candida, a common crop pest, prefers to consume yeast instead of lettuce seedlings. The authors confirmed that even with the availability of both lettuce seedlings and yeast in the same dish, Folsomia candida preferred to eat the yeast, thereby reducing the number of feeding injuries on the lettuce seedlings. The authors propose that using this preference for yeast may be a way to mitigate crop damage by this pest.

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Toxicity of aminomethylphosphonic acid via the Wnt signaling pathway as a novel mechanism

Zhuang et al. | Mar 08, 2023

Toxicity of aminomethylphosphonic acid via the Wnt signaling pathway as a novel mechanism
Image credit: Image credit: Dapur Melodi

The Wnt signaling pathway, known to coordinate important aspects of cellular homeostasis ranging from differentiation, proliferation, migration, and much more, is dysregulated in many human diseases. This study demonstrates that aminomethylphosphonic acid, which is the main metabolite found in the common herbicide Glyphosate, is toxic to planaria and capable of binding to canonical Wnt proteins.

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The Potential of Fibroblast Growth Factors to Stimulate Hair Growth In Vitro

Cheng et al. | Nov 07, 2021

The Potential of Fibroblast Growth Factors to Stimulate Hair Growth In Vitro

Identifying treatments that can stimulate hair growth use could help those struggling with undesirable hair loss. Here, the authors show that Fibroblast Growth Factors can stimulate the division of cells isolated from the mouse hair follicle. Their results suggest that this family of growth factors might be helpful in stimulating hair growth in living animals as well.

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Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1

Jang et al. | Aug 19, 2016

Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1

Polo-like kinase 1 (Plk1) is a master regulator of mitosis, initiating key steps of cell cycle regulation, and its overexpression is associated with certain types of cancer. In this study, the authors carefully designed peptides that were able to bind to Plk1 at a location that is important for its proper localization and function. Future studies could further develop these peptides to selectively target Plk1 in cancer cells and induce mitotic arrest.

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