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Comparative Analysis of Vital Capacities of Athletes, Singers and Other Students of Age 13-14 Years: A Cross-Sectional Observational Study

Taneja et al. | Sep 30, 2019

Comparative Analysis of Vital Capacities of Athletes, Singers and Other Students of Age 13-14 Years: A Cross-Sectional Observational Study

Physical activity when performed regularly has beneficial effects on all systems of the body, including pulmonary functions. This study, conducted at Springdales School in Dhaula Kuan, New Delhi, aimed to determine the effect of sports and singing on the vital capacity (the maximum amount of air a person can expel from the lungs after a maximum inhalation), an important measure of pulmonary health.

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The effect of Omega-3 on bovine blood cells as a potential remedy for Cerebral Cavernous Malformations

Pulluru et al. | Sep 22, 2023

The effect of Omega-3 on bovine blood cells as a potential remedy for Cerebral Cavernous Malformations
Image credit: Carolien van Oijen

Here, the authors investigated if dietary Omega-3 fatty acids could reduce the potential for cerebral cavernous malformations, which are brain lesions that occur due to a genetic mutation where high membrane permeability occurs between endothelial cell junctions. In a bovine-based study where some cows were fed an Omega-3 diet, the authors found the membranes of bovine blood cells increased in thickness with Omega-3 supplementation. As a result, they suggest that dietary Omega-3 could be considered as a possible preventative measure for cerebral cavernous malformations.

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An Analysis of the Mathematical Accuracy of Perspective in Paintings

Grewal et al. | Dec 13, 2019

An Analysis of the Mathematical Accuracy of Perspective in Paintings

Here the authors investigate whether there are mathematical inaccuracies of perspective in artists' paintings that are undetectable with our naked eyes. Using the cross-ratio method, they find that there are three significant errors in various famous paintings which increase as the structures in the paintings recede from the viewer.

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Modulation of VEGF and TGF beta in 5-FU induced inflammation in MCF-7 using an herbal formulation

Vinay Nair et al. | Jun 03, 2022

Modulation of VEGF and TGF beta in 5-FU induced inflammation in MCF-7 using an herbal formulation

Acquired drug resistance is an increasing challenge in treating cancer with chemotherapy. One mechanism
behind this resistance is the increased inflammation that supports the progression and development of
cancer that arises because of the drug’s presence. Integrative oncology is the field that focuses on including natural products alongside traditional therapy to create a treatment that focuses on holistic patient well-being.
In this study, the authors demonstrate that the use of an herbal formulation, consisting of turmeric and green tea, alongside a traditional chemotherapeutic drug, 5-fluorouracil (FU) significantly decreases the level of cytokines produced in breast cancer cells when compared to the levels produced when exposed solely to the chemo drug. The authors conclude that this combination of treatment, based on the principle of integrative oncology, shows potential for reducing the resistance against treatment conferred through increased inflammation. Consequently, this suggests a prospective way forward in improving the efficacy of cancer treatment.

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A new therapy against MDR bacteria by in silico virtual screening of Pseudomonas aeruginosa LpxC inhibitors

Liu et al. | Apr 27, 2022

A new therapy against MDR bacteria by <em>in silico</em> virtual screening of <em>Pseudomonas aeruginosa</em> LpxC inhibitors

Here, seeking to address the growing threat of multidrug-resistant bacteria (MDR). the authors used in silico virtual screening to target MDR Pseudomonas aeruginosa. They considered a key protein in its biosynthesis and virtually screened 20,000 candidates and 30 derivatives of brequinar. In the end, they identified a possible candidate with the highest degree of potential to inhibit the pathogen's lipid A synthesis.

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The characterization of quorum sensing trajectories of Vibrio fischeri using longitudinal data analytics

Abdel-Azim et al. | Dec 16, 2023

The characterization of quorum sensing trajectories of <i>Vibrio fischeri</i> using longitudinal data analytics

Quorum sensing (QS) is the process in which bacteria recognize and respond to the surrounding cell density, and it can be inhibited by certain antimicrobial substances. This study showed that illumination intensity data is insufficient for evaluating QS activity without proper statistical modeling. It concluded that modeling illumination intensity through time provides a more accurate evaluation of QS activity than conventional cross-sectional analysis.

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An Exploration of a Honey-Ginger Supplement as an Antimicrobial Agent

Phillips et al. | Jul 10, 2016

An Exploration of a Honey-Ginger Supplement as an Antimicrobial Agent

Due to the increase in antimicrobial resistance, alternative medicinal therapies are being explored. Studies have shown that honey and ginger alone have antimicrobial effects on the genera Staphylococcus and Escherichia, including S. epidermidis and E. coli. The authors of this study tested whether a honey-ginger supplement, Jengimiel™, could be used as an antimicrobial agent against S. epidermidis and E. coli K-12.

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Phages Can Be More Effective and Specific Than Antibiotics in Combating Bacteria

Wu et al. | Feb 17, 2019

Phages Can Be More Effective and Specific Than Antibiotics in Combating Bacteria

Phage therapy has been suggested as an alternative to antibiotics because bacteria resistant to antibiotics may still be susceptible to phages. However, phages may have limited effectiveness in combating bacteria since bacteria possess several antiviral defense mechanisms and can quickly develop resistance to phages. In this study, Wu and Pinta compare the effectiveness and specificity of antibiotics and phages in combating bacteria. They found that T4 phages are more specific and effective in fighting or inhibiting both antibiotic-resistant and sensitive bacteria than antibiotics, suggesting that phage therapy can be developed as an efficient tool to combat antibiotic-resistant bacteria.

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Analysis of ultraviolet light as a bactericide of gram-negative bacteria in Cladophora macroalgae extracts

Newell et al. | Nov 07, 2022

Analysis of ultraviolet light as a bactericide of gram-negative bacteria in <em>Cladophora</em> macroalgae extracts

Here, the authors sought to use Cladophora macroalgae as a possible antibiotic to address the growing threat of antibiotic resistance in pathogenic bacteria. However, when they observed algae extracts to be greatly contaminated with gram-negative bacteria, they adapted to explore the ability to use ultraviolet light as a bactericide. They found that treatment with ultraviolet light had a significant effect.

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Enhancing activity of antibiotics against Staphylococcus aureus with Shuang-Huang-Lian

Liu et al. | Sep 29, 2022

Enhancing activity of antibiotics against Staphylococcus aureus with Shuang-Huang-Lian

Staphylococcus aureus is a major pathogen in both hospitals and the community and can cause systemic infections such as pneumonia. Multi-drug resistant strains, such as Methicillin-resistant S. aureus (MRSA) are particularly worrisome. In order to reduce the development of bacterial resistance, we hypothesized that two selected traditional Chinese medicines, Shuang-Huang-Lian (SHL) and Lan-Qin, would be effective against S. aureus. The results showed that SHL had a synergistic effect with gentamicin as well as additive effects with penicillin and cefazolin against S. aureus compared with using antibiotics alone.

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