Amyotrophic lateral sclerosis (ALS) affects nearly 200,000 people worldwide and there is currently no cure. The purpose of the study was to determine if Helianthus annuus seeds helped reduce nerve degeneration and increase locomotion using Drosophila melanogaster as the model organism. Through this experiment, we found a general trend suggesting that H. annuus helped increase the mobility of the D. melanogaster suggesting it could be a viable supplement for patients with ALS.

In this study, the authors investigate a potential case of cross antibiotic-resistance. Using swabs from an individual who received long-term treatments of azithromycin, they addressed the question of whether any bacteria in this individual might develop resistance to not only azithromycin, but also other antibiotics with similar structures. This study cleverly addresses the important issue of antibiotic resistance from a new and thoughtful approach.

Caenorhabditis elegans xpa-1 and him-1 are orthologs of human XPA and human SMC1A, respectively. Mutations in the XPA are correlated with Xeroderma pigmentosum, a condition that induces hypersensitivity to ultraviolet (UV) radiation. Alternatively, SMC1A mutations may lead to Cornelia de Lange Syndrome, a multi-organ disorder that makes patients more sensitive to UVinduced DNA damage. Both C. elegans genes have been found to be involved in protection against UV radiation, but their combined effects have not been tested when they are both knocked down. The authors hypothesized that because these genes are involved in separate pathways, the simultaneous knockdown of both of these genes using RNA interference (RNAi) in C. elegans will cause them to become more sensitive to UV radiation than either of them knocked down individually. UV protection was measured via the percent survival of C. elegans post 365 nm and 5.4x10-19 joules of UV radiation. The double xpa-1/him-1 RNAi knockdown showed a significantly reduced percent survival after 15 and 30 minutes of UV radiation relative to wild-type and xpa-1 and him-1 single knockdowns. These measurements were consistent with their hypothesis and demonstrated that xpa-1 and him-1 genes play distinct roles in resistance against UV stress in C. elegans. This result raises the possibility that the xpa-1/him-1 double knockdown could be useful as an animal model for studying the human disease Xeroderma pigmentosum and Cornelia de Lange Syndrome.

We conducted this research as our start-up's research that addresses the problem of biogas production in cow-dense regions like India. We hypothesized that the thermophilic temperature (45-60^oC) would increase biogas production. The production process is much faster and more abundant at temperatures around 55-60^oC.

The study explored the role of testosterone beyond its well-established effects on male sex characteristics, focusing on its association with non-communicable diseases (NCDs) like obesity and type 2 diabetes (T2D), using Mendelian randomization (MR) analysis on genomic data.

The authors compare neuroimaging datasets to identify potential new biomarkers for earlier detection of Alzheimer's disease.

The authors looked at whether youth use of marijuana related to later high-risk drug use. Using survey data from 2010-2019 they found that youth marijuana use did correlate to an increased risk of high-risk drug use.

In this manuscript the authors looked at current vaccine strategies against different strains of influenza. Looking at several factors they found that influenza strain as well as vaccinated age group, among other factors, impact vaccine effectiveness.

This article describes the relationship between socioeconomic factors and the extent of how the COVID-19 Pandemic affected communities. Factors such as infection rate, vaccination rate, and economic status were all evaluated within the context of this article.

In this study, the authors investigate differences in psychological outcomes from patients who undergo different surgical procedures.