![Innovative Treatment for Reducing Senescence and Revitalizing Aging Cells through Gene Silencing](/rails/active_storage/representations/proxy/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaHBBdlFMIiwiZXhwIjpudWxsLCJwdXIiOiJibG9iX2lkIn19--a389cfe284f237ad2921dd1580e65e70e23ed698/eyJfcmFpbHMiOnsibWVzc2FnZSI6IkJBaDdCem9MWm05eWJXRjBTU0lJY0c1bkJqb0dSVlE2QzNKbGMybDZaVWtpRFRZd01IZzJNREErQmpzR1ZBPT0iLCJleHAiOm51bGwsInB1ciI6InZhcmlhdGlvbiJ9fQ==--33b2b080106a274a4ca568f8742d366d42f20c14/Figure%203_revised.png)
Cellular senescence plays a key role in aging cells and is attributed to a number of disease and pathology. These authors find that genetic editing of both RPS6KB1 and PPARGC1A revitalizes a human skin fibroblast cell line.
Read More...Innovative Treatment for Reducing Senescence and Revitalizing Aging Cells through Gene Silencing
Cellular senescence plays a key role in aging cells and is attributed to a number of disease and pathology. These authors find that genetic editing of both RPS6KB1 and PPARGC1A revitalizes a human skin fibroblast cell line.
Read More...Tap water quality analysis in Ulaanbaatar City
There have been several issues concerning the water quality in Ulaanbaatar, Mongolia in the past few years. This study, we collected 28 samples from 6 districts of Ulaanbaatar to check if the water supply quality met the standards of the World Health Organization, the Environmental Protection Agency, and a Mongolian National Standard. Only three samples fully met all the requirements of the global standards. Samples in Zaisan showed higher hardness (>120 ppm) and alkalinity levels (20–200 ppm) over the other districts in the city. Overall, the results show that it is important to ensure a safe and accessible water supply in Ulaanbaatar to prevent future water quality issues.
Read More...Taft linear free-energy relationships in the biocatalytic hydrolysis of sterically hindered nitrophenyl ester substrates
This study applies Taft linear free-energy relationships to study kinetic trends in the enzymatic hydrolysis of sterically hindered substrates.
Read More...Correlation of Prominent Intelligence Type & Coworker Relations
Ashley Moulton & Joseph Rasmus investigate 9 controversial categories of intelligence as predicted by Multiple Intelligence Theory, originally proposed in the mid-1980s. By collecting data from 56 participants, they record that there may not actually be a correlation between these categorical types when it comes to workplace atmosphere and project efficiency.
Read More...Preliminary investigation of Allosauroidea facial integument and the evolution of theropod facial armor
The facial integument, or external skin tissues, were assessed on set of dinosaurs from the Allosauroidea clade to test whether dermal patterns served specific functions.
Read More...A study on the stretching behavior of rubber bands
Here, the authors considered the stretching behavior of rubber bands by exposing the rubber bands to increasing loads and measuring their stretch response. They found that a linear stretch response was observed for intermediate loading steps, but this behavior was lost at lower or higher loads, deviating from Hooke's Law. The authors suggest that studies such as these can be used to evaluate other visco-elastic structures.
Read More...Inhibiting the ERK pathway and the TRPM7 ion channel in gastric and bladder cancer cells
In this work the authors investigate new possible treatment methods for gastric and bladder cancers. They specifically targeted the transient receptor potential cation subfamily M member 7 (TRPM7), an ion channel that plays an important role in the survival of both of these cancers, and extracellular regulated kinases (ERKs),which contributes to the carcinogenesis of many cancers including gastric cancer. As a result, the authors consider the effects of Ginsenoside Rd, NS8593, curcumin, and icariin , known to inhibit TRPM7 and ERK. The authors found that these treatments decrease proliferation and induce apoptosis in studies of gastric and bladder cancer cells.
Read More...Awareness of plastic pollution and adoption of green consumer lifestyles among students from high school
In this study, the authors test ways to increase knowledge of green consumerism amongst high school students. Their knowledge was measured based on the New Ecological Paradigm Scale.
Read More...Effects of an Informational Waste Management App on a User’s Waste Disposal Habits
While 75% of waste in the United States is stated to be recyclable, only about 34% truly is. This project takes a stance to combat the pillars of mismanaged waste through a modern means of convenience: the TracedWaste app. The purpose of this study was to identify how individuals' waste disposal habits improved and knowledge increased (i.e. correctly disposing of waste, understanding negative incorrect waste disposal) due to their use of an informational waste management app as measured by a survey using a 1-5 Likert Scale. The results showed that the TracedWaste app helped conserve abundant resources such as energy and wood, decrease carbon emissions, and minimize financial toll all through reducing individual impact.
Read More...The effects of stress on the bacterial community associated with the sea anemone Diadumene lineata
In healthy ecosystems, organisms interact in a relationship that helps maintain one another's existence. Stress can disrupt this interaction, compromising the survival of some of the members of such relationships. Here, the authors investigate the effect of stress on the interaction between anemones and their microbiome. Their study suggests that stress changes the composition of the surface microbiome of the anemone D. lineata, which is accompanied by an increase in mucus secretion. Future research into the composition of this stress-induced mucus might reveal useful antimicrobial properties.
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