High-fructose diets consumed widely in modern societies predisposes to metabolic diseases such as diabetes. Using the worm C. elegans, the authors of this study investigated the effect of fructose on the worm's survival rates. They found that worms fed 15% fructose had a lower life expectancy than those on a fructose-free diet. These results suggest that, like in humans, fructose has a negative effect on worm survival, which makes them an easy, attractive model to study the effects of fructose on health.
Hemani et al. tackled the problem of rampant hospital waste by implementing staff training to help inform hospital workers about proper waste disposal. The authors observed a significant increase in proper waste disposal after the training, showing that simple strategies, such as in-person classroom training and posters, can have a profound effect on limiting improper waste handling.
Here, recognizing the recognizing the growing threat of non-biodegradable plastic waste, the authors investigated the ability to use a modified enzyme identified in bacteria to decompose polyethylene terephthalate (PET). They used simulations to screen and identify an optimized enzyme based on machine learning models. Ultimately, they identified a potential mutant PETases capable of decomposing PET with improved thermal stability.
Chronic alcohol consumption can cause cardiac myopathy, which afflicts about 500,000 Americans annually. Gunturi et al. wanted to understand the effects of alcohol on heart rate and confirm the role of nitric oxide (NO) signaling in heart rate regulation. Using the model organism Daphnia magna, a water crustacean with a large, transparent heart, they found that the heart rate of Daphnia magna was reduced after treatment with alcohol. This depression could be reversed after treatment with inhibitors of NO synthesis and signaling. Their work has important implications for how we understand alcohol-induced effects on heart rate and potential treatments to reverse heart rate depression as a result of alcohol consumption.
In this study, the authors engineer a cost-effective and bio-friendly water purification system using limestone, denitrifying bacteria, and sulfate-reducing bacteria. They evaluated its efficacy with samples from Eastern PA industrial sites.
The use of fertilizers is associated with an increase in soil degradation, which is predicted to lead to a decrease in crop production within the next decade. Thus, it is critical to find solutions to support crop production to sustain the robust global population. In this study, the authors investigate how probiotic bacteria, like Rhizobium leguminosarum, Bacillus subtilis and Pseudomonas fluorescens, can impact the growth of Arabidopsis thaliana when applied to the seeds.They hypothesized that solutions with multiple bacterial species compared to those with only a single bacterial species would promote seed germination more effectively.
In this article, the authors identify the characteristics that make a book a best-seller. Knowing what, besides content, predicts the success of a book can help publishers maximize the success of their print products.
In this work, the authors develop an algorithm that solves the problem of efficient space travel between planets. This is a problem that could soon be of relevance as mankind continues to expand its exploration of outer space, and potentially attempt to inhabit it.
In this study, the authors looked at a proto-oncogene, KRAS, and searched for molecules that are predicted to be able to bind to the inactive form of KRAS. They found that a modified version of Irbesartan, a derivative of benzimidazole, showed the best binding to inactive KRAS.
Researchers query whether reading comprehension is the same, worse, or better when using e-books as compared with standard paper texts. This study evaluated this question in the elementary school population. Our hypothesis was that information would be retained equally whether read from paper or from an electronic device. Each participant read four stories, alternating between electronic and paper media types. After each reading, the participants completed a five-question test covering the information read. The study participants correctly answered 167 out of 200 comprehension questions when reading from an electronic device. These same participants correctly answered 145 out of 200 comprehension questions when reading from paper. At a significance level of p < 0.05, the results showed that there was a statistically significant difference in reading comprehension between the two media, demonstrating better comprehension when using electronic media. The unexpected results of this study demonstrate a shift in children’s performance and desirability of using electronic media as a reading source.