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Phospholipase A2 increases the sensitivity of doxorubicin induced cell death in 3D breast cancer cell models

Lee et al. | Mar 30, 2022

Phospholipase A2 increases the sensitivity of doxorubicin induced cell death in 3D breast cancer cell models

Inefficient penetration of cancer drugs into the interior of the three-dimensional (3D) tumor tissue limits drugs' delivery. The authors hypothesized that the addition of phospholipase A2 (PLA2) would increase the permeability of the drug doxorubicin for efficient drug penetration. They found that 1 mM PLA2 had the highest permeability. Increased efficiency in drug delivery would allow lower concentrations of drugs to be used, minimizing damage to normal cells.

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Vitamin C in Fruits: Does Organic Make a Difference?

Mulukutla et al. | Sep 21, 2015

Vitamin C in Fruits: Does Organic Make a Difference?

Vitamin C is an essential nutrient that is involved in many important cellular processes. Humans are unable to produce Vitamin C and thus must obtain it from exogenous sources such as citrus fruits, peppers, or flowering vegetables. In this study, the authors investigate whether or not organic and non-organic fruits have comparable vitamin C levels. This type of study has important implications for consumers.

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Does Gaming Improve Cognitive Skills?

Chakravarti et al. | Jan 26, 2015

Does Gaming Improve Cognitive Skills?

Playing video games may improve mental performance by encouraging practicing logical reasoning skills. Students who played video games in between two tests tended to perform better on the second test than those that did not play video games.

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Does technology help or hurt learning? Evidence from middle school and high school students

Lu et al. | Oct 02, 2022

Does technology help or hurt learning? Evidence from middle school and high school students

Here, recognizing the vastly different opinion held regarding device usage, the authors considered the effects of technology use on middle and high school students' learning effectiveness. Using an anonymous online survey they found partial support that device use at school increases learning effectiveness, but found strong support for a negative effect of technology use at home on learning effectiveness. Based on their findings they suggest that the efficacy of technology depends on environmental context along with other important factors that need consideration.

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Racemic serine is less soluble than pure enantiomers due to stronger intermolecular hydrogen bonds

Ranka et al. | Nov 18, 2021

Racemic serine is less soluble than pure enantiomers due to stronger intermolecular hydrogen bonds

Seeking to develop a better understanding of the chemical and physical properties of amino acids that compose proteins, here the authors investigated the unusual relative insolubility of racemic mixtures of D- and L-serine compared to the solubility of pure D- or L-serine. The authors used a combination of microscopy and temperature measurements alongside previous X-ray diffraction studies to conclude that racemic DL-serine crystals consist of comparatively stronger hydrogen bond interactions compared to crystals of pure enantiomers. These stronger interactions were found to result in the unique release of heat during the crystallization of racemic mixtures.

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How does light affect the distribution of Euglena sp. and Tetrahymena pyriformis

Singh et al. | Mar 03, 2022

How does light affect the distribution of <em>Euglena sp.</em> and <em>Tetrahymena pyriformis</em>

In this article, the authors explored the locomotory movement of Euglena sp. and Tetrahymena pyriformis in response to light. Such research bears relevance to the migration and distribution patterns of both T. pyriformis and Euglena as they differ in their method of finding sustenance in their native environments. With little previous research done on the exploration of a potential response to photostimulation enacted by T. pyriformis, the authors found that T. pyriformis do not bias in distribution towards areas of light - unlike Euglena, which displayed an increased prevalence in areas of light.

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