In this study, the authors conduct a series of experiments within an elevator traveling on an angle to determine if Einstein's Equivalency Principle and motion vector decomposition can be used to calculate the angle of inclination.
Read More...Extending Einstein’s elevator thought experiment to multiple spatial dimensions at the Luxor Hotel & Casino
In this study, the authors conduct a series of experiments within an elevator traveling on an angle to determine if Einstein's Equivalency Principle and motion vector decomposition can be used to calculate the angle of inclination.
Read More...Transcriptional Regulators are Upregulated in the Substantia Nigra of Parkinson’s Disease Patients
This article investigates differences in gene expression in the brains of patients with and without Parkinson's disease. The authors identify a crucial transcriptional regulator may be a relevant target for future therapeutic treatment for Parkinson's disease.
Read More...Contrasting role of ASCC3 and ALKBH3 in determining genomic alterations in Glioblastoma Multiforme
Glioblastoma Multiforme (GBM) is the most malignant brain tumor with the highest fraction of genome alterations (FGA), manifesting poor disease-free status (DFS) and overall survival (OS). We explored The Cancer Genome Atlas (TCGA) and cBioportal public dataset- Firehose legacy GBM to study DNA repair genes Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) and Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3 (ALKBH3). To test our hypothesis that these genes have correlations with FGA and can better determine prognosis and survival, we sorted the dataset to arrive at 254 patients. Analyzing using RStudio, both ASCC3 and ALKBH3 demonstrated hypomethylation in 82.3% and 61.8% of patients, respectively. Interestingly, low mRNA expression was observed in both these genes. We further conducted correlation tests between both methylation and mRNA expression of these genes with FGA. ASCC3 was found to be negatively correlated, while ALKBH3 was found to be positively correlated, potentially indicating contrasting dysregulation of these two genes. Prognostic analysis showed the following: ASCC3 hypomethylation is significant with DFS and high ASCC3 mRNA expression to be significant with OS, demonstrating ASCC3’s potential as disease prediction marker.
Read More...Misconceptions Regarding Blindness Are Prevalent: Possible Implications for Best-Practices and Policy Making
The authors conduct a survey to investigate the perceptions both sighted and blind people have on blindness. The results reveal both groups perceive the most challenging adversities to be the lack of awareness and understanding of their circumstances.
Read More...Bacterial Load Consistency Among Three Independent Water Distribution Systems
Clean drinking water is an essential component to maintaining public health. The authors of this study tested the bacterial load of water from three different disinfection and filtration systems in order to determine which system might be superior.
Read More...Elucidating the Genotoxicity of Synthetic Food Preservatives with the SOS Chromotest
Evidence suggests certain food preservatives may be genotoxic due to their ability to impair normal cellular pathways. The authors investigated the genotoxic potential and effects of commonly used synthetic food preservatives, specifically sodium nitrite, potassium sulfate, and hydrogen peroxide.
Read More...A cost-effective IoT-based intelligent indoor air quality monitoring
Poor air quality is associated with negative effects on human health but can be difficult to measure in an accurate and cost-effective manner. The authors design and test a monitor for measuring indoor air quality using low-cost components.
Read More...Household spices and minerals as alternative disinfectants for mobile phones
In this study, the authors investigate the disinfectant potential of many household spices and minerals. More specifically, they test whether these compounds can be used to disinfect mobile phones after daily use with the hope of identifying environmentally-friendly cleaning options.
Read More...The Effects of Ultraviolet Light on Escherichia coli
In this study E. coli bacteria was exposed to small UV lights currently used in school laboratories to see the effect on colony growth. This project explores how UV radiation methods could be applied in common households to inhibit bacterial growth.
Read More...Assessing CDK5 as a Nanomotor for Chemotactic Drug Delivery
Enzyme chemotaxis is a thermodynamic phenomenon in which enzymes move along a substrate concentration gradient towards regions with higher substrate concentrations and can be used to steer nanovehicles towards targets along natural substrate concentrations. In patients with Alzheimer’s disease, a gradient of tau protein forms in the bloodstream. Tau protein is a substrate of the enzyme CDK5, which catalyzes the phosphorylation of tau protein and can travel using chemotaxis along tau protein gradients to increasing concentrations of tau and amyloid-beta proteins. The authors hypothesized that CDK5 would be able to overcome these barriers of Brownian motion and developed a quantitative model using Michaelis-Menten kinetics to define the necessary parameters to confirm and characterize CDK5’s chemotactic behavior to establish its utility in drug delivery and other applications.
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