Parkinson's disease is a neurodegenerative disorder that affects over 10 million people worldwide. It is caused by destruction of dopamine-producing neurons, which results in severe motor and movement symptoms. In this study, the authors investigated the anti-Parkinsonian effects of two natural compounds curcumin and nicotinamide using C. elegans as a model organism.
Saccharomyces cerevisiae yeast is used to produce bioethanol, an alternative to fossil fuels. In this study, authors take advantage of this well studied yeast by genetically engineering them to increase fatty acid biosynthesis and culturing in a cost-effective wastewater based medium; potentially providing a sustainable alternative to petrochemicals.
This study collected samples from water bodies near hog farms and an aquatic environment not near a hog farm. It was hypothesized that water bodies near the hog farms would have lower water quality with higher turbidity, total dissolved solids (TDS), and pH than the water body not in proximity to a hog farm because of water contamination with hog waste. Results showed that the turbidity was 4–6 times higher, TDS was 1.5–2 times higher, and pH was 3 units higher in the 2 experimental locations compared to the control location. This study and its findings are important for understanding the impact of hog farming on the proximal water bodies.
Head injuries are common in American football and the facemasks found on football helmets receive a lot of impact during contacts. This study investigates how effective they are at reducing concussion risk.
The consumption of sugar substitute non-nutritive sweeteners (NNS) has dramatically increased in recent years. Despite being advertised as a healthy alternative, NNS have been linked to adverse effects on the body, such as neurodegenerative diseases (NDs). In NDs, neural stem cell function is impaired, which inhibits neuron regeneration. The purpose of this study was to determine if the NNS acesulfame potassium (Ace-K) and neotame affect planaria neuron regeneration rates. Since human neurons may regenerate, planaria, organisms with extensive regenerative capabilities due to stem cells called neoblasts, were used as the model organism. The heads of planaria exposed to either a control or non-toxic concentrations of NNS were amputated. The posterior regions of the planaria were observed every 24 hours to see the following regeneration stages: (1) wound healing, (2) blastema development, (3) growth, and (4) differentiation. The authors hypothesized that exposure to the NNS would slow planaria regeneration rates. The time it took for the planaria in the Ace-K group and the neotame group to reach the second, third, and fourth regeneration stage was significantly greater than that of the control. The results of this study indicated that exposure to the NNS significantly slowed regeneration rates in planaria. This suggests that the NNS may adversely impact neoblast proliferation rates in planaria, implying that it could impair neural stem cell proliferation in humans, which plays a role in NDs. This study may provide insight into the connection between NNS, human neuron regeneration, and NDs.
Vitamin C is an essential nutrient that is involved in many important cellular processes. Humans are unable to produce Vitamin C and thus must obtain it from exogenous sources such as citrus fruits, peppers, or flowering vegetables. In this study, the authors investigate whether or not organic and non-organic fruits have comparable vitamin C levels. This type of study has important implications for consumers.
In this study E. coli bacteria was exposed to small UV lights currently used in school laboratories to see the effect on colony growth. This project explores how UV radiation methods could be applied in common households to inhibit bacterial growth.
Berberine is a natural quaternary alkaloid that has anti-microbial and anti-cancer effects. This compound can bind to Guanine Quadruplex (G4) DNA secondary complexes to help inhibit cancer cell proliferation. In this study, the authors investigate whether incorporating large aromatic rings helps to stabilize berberine-G4 interactions.
In an extensive study of gene mutations, and their resulting effect on protein-protein interactions, Desai and Stork found that HTT-PRPF40B-MECP2 interactions are weakened with progression of Lopes-Maciel-Rodan syndrome.
Studying exoplanets, or planets that orbit a star other than the Sun, is critical to a greater understanding the formation of planets and how Earth's solar system differs from others. In this study the authors analyze the transit light curves of three hot Jupiter exoplanets to ultimately determine if and how these planets have changed since their discovery.