The printing-related expenditure that is budgeted in 2014 for U.S. Federal agencies is $1.8 billion. A sample of five publically available documents produced by various federal agencies is analyzed and the cost savings arising from a change in font type are estimated. The analysis predicts that the Government’s annual savings by switching to Garamond are likely to be about $234 million with worst-case savings of $62 million and best-case savings of $394 million. Indirect benefits arising from a less detrimental impact on the environment due to lower ink production and disposal volumes are not included in these estimates. Times New Roman is not as efficient as Garamond, and the third federally-recommended font, Century Gothic, is actually worse on average than the fonts used in the sample documents.

Oxidative damage and neuro-inflammation were the key pathways implicated in the pathogenesis of Alzheimer’s disease. In this study, 30 natural extracts from plant roots and leaves with extensive anti-inflammatory and anti-oxidative properties were consumed by Drosophila melanogaster. Several assays were performed to evaluate the efficacy of these combinational extracts on delaying the progression of Alzheimer’s disease. The experimental group showed increased motor activity, improved associative memory, and decreased lifespan decline relative to the control group.

Sesame (Sesamum indicum) and moringa (Moringa oleifera) have natural antioxidants that could prevent cancer growth. Previously, this group found that sesame and moringa individually suppress eye tumor grown in the Drosophila melanogaster model. In the present study, combinations of sesame and moringa at different concentrations were included in the D. melanogaster diet. The impact on eye tumor development was assessed at different stages of growth.

Ultraviolet (UV) radiation is known to alter DNA structure and impair cellular function in all living organisms. In this study, Lateef et al examine the effects of UV radiation to determine whether antioxidant-enriched nutrition can combat the potential deleterious effects of UV radiation on Drosophila melanogaster. They found that UVB (320nm) radiation caused a 59% decrease in the Drosophila lifespan and mutagenic effects on flies' physical appearance, but did not significantly affect fertility. Curcumin significantly prolonged lifespan and enhanced fertility for both UV- and non-UV-exposed flies. The research demonstrates the positive potential of natural antioxidants as weapons against radiation-induced diseases including cancer.

The cause of insect colony collapse disorder (CCD) is still a mystery. In this study, the authors aimed to test the effects of two environmental factors, water vapor and smoke levels, on the social behavior and physical condition of insects. Their findings could help shed light on how changing environmental factors can contribute to CCD.

People are quick to accept the assumption that a light will appear dimmer the farther away they are, citing the inverse square relationship that illuminance obeys as rationale. However, repeated observations of light sources maintaining their brightness over large distances prompted us to explore how the brightness, or perceived illuminance of a light varies with the viewing distance from the object. We hypothesized that since both the illuminance of the light source and image size decrease at the same rate, then the concentration, or intensity of the image remains unchanged, and subsequently the perceived illuminance.

In this study, the authors investigate differences in psychological outcomes from patients who undergo different surgical procedures.

Osteosarcoma is a type of bone cancer that affects young adults and children. Early diagnosis of osteosarcoma is crucial to successful treatment. The current methods of diagnosis, which include imaging tests and biopsy, are time consuming and prone to human error. Hence, we used deep learning to extract patterns and detect osteosarcoma from histological images. We hypothesized that the combination of two different technologies (transfer learning and data augmentation) would improve the efficacy of osteosarcoma detection in histological images. The dataset used for the study consisted of histological images for osteosarcoma and was quite imbalanced as it contained very few images with tumors. Since transfer learning uses existing knowledge for the purpose of classification and detection, we hypothesized it would be proficient on such an imbalanced dataset. To further improve our learning, we used data augmentation to include variations in the dataset. We further evaluated the efficacy of different convolutional neural network models on this task. We obtained an accuracy of 91.18% using the transfer learning model MobileNetV2 as the base model with various geometric transformations, outperforming the state-of-the-art convolutional neural network based approach.

Since cough syrup and mouthwash are commonly used items and often end up flushed down the drain or toilet, they can eventually find their way into into freshwater waterways which can be harmful to many marine organisms, such as planarians (aquatic flatworms). To investigate the effects of these substances on planarians, the authors considered different concentrations of Listerine mouthwash and Robitussin syrup along with their active ingredients. By using a behavioral assay, they identified that the active ingredients of cough syrup detrimentally affect planarian behavior. They suggest that these findings could be used to guide disposal methods to lessen detrimental effects on aquatic life.

Did the COVID-19 pandemic and travel restrictions improve air quality? The authors investigate this question in New York City using existing pollution data and forecasting trends.