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The Effects of Ezetimibe on Triglyceride and Alanine Transaminase Reduction in Drosophila Melanogaster Model of Nonalcoholic Fatty Liver Disease (NAFLD)

Dania et al. | Apr 30, 2020

The Effects of Ezetimibe on Triglyceride and Alanine Transaminase Reduction in <i>Drosophila Melanogaster</i> Model of Nonalcoholic Fatty Liver Disease (NAFLD)

Nonalcoholic Fatty Liver Disease (NAFLD) is a condition where a surplus of triglycerides or fat are present in the liver. In this study, ezetimibe, a cholesterol lowering drug, was used to treat flies modeling NAFLD. Compared to the coconut oil fed flies that were transferred to the control medium, the flies transferred to the control medium treated with ezetimibe showed a decrease in their triglyceride and alanine transaminase level.

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Molecular Alterations in a High-Fat Mouse Model Before the Onset of Diet–Induced Nonalcoholic Fatty Liver Disease

Lee et al. | Sep 20, 2016

Molecular Alterations in a High-Fat Mouse Model Before the Onset of Diet–Induced Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases worldwide, but there are few studied warning signs for early detection of the disease. Here, researchers study alterations that occur in a mouse model of NAFLD, which indicate the onset of NAFLD sooner. Earlier detection of diseases can lead to better prevention and treatment.

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Utilizing a Wastewater-Based Medium for Engineered Saccharomyces cerevisiae for the Biological Production of Fatty Alcohols and Carboxylic Acids to Replace Petrochemicals

Ramesh et al. | Oct 02, 2019

Utilizing a Wastewater-Based Medium for Engineered <em>Saccharomyces cerevisiae</em> for the Biological Production of Fatty Alcohols and Carboxylic Acids to Replace Petrochemicals

Saccharomyces cerevisiae yeast is used to produce bioethanol, an alternative to fossil fuels. In this study, authors take advantage of this well studied yeast by genetically engineering them to increase fatty acid biosynthesis and culturing in a cost-effective wastewater based medium; potentially providing a sustainable alternative to petrochemicals.

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The effect of Omega-3 on bovine blood cells as a potential remedy for Cerebral Cavernous Malformations

Pulluru et al. | Sep 22, 2023

The effect of Omega-3 on bovine blood cells as a potential remedy for Cerebral Cavernous Malformations
Image credit: Carolien van Oijen

Here, the authors investigated if dietary Omega-3 fatty acids could reduce the potential for cerebral cavernous malformations, which are brain lesions that occur due to a genetic mutation where high membrane permeability occurs between endothelial cell junctions. In a bovine-based study where some cows were fed an Omega-3 diet, the authors found the membranes of bovine blood cells increased in thickness with Omega-3 supplementation. As a result, they suggest that dietary Omega-3 could be considered as a possible preventative measure for cerebral cavernous malformations.

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Effect of Different Growth Media on Algae’s Ability for Carbon Dioxide Biofixation

Chaudhuri et al. | Oct 12, 2020

Effect of Different Growth Media on Algae’s Ability for Carbon Dioxide Biofixation

In this study, the authors investigate the effects of different algal growth media on algae's ability to perform carbon dioxide biofixation, or utilize carbon dioxide by fixing it into fatty acids within the cells. More specifically, carbon dioxide biofixation of Chlorella vulgaris was cultured in one of four media options and carbon dioxide was measured and compared to controls. The study results demonstrated that the use of media can enhance algae's capacity for biofixation and this has important implications for developing methods to reduce carbon dioxide in the environment.

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