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Effect of natural compounds curcumin and nicotinamide on α-synuclein accumulation in a C. elegans model of Parkinson’s disease

Mehrotra et al. | Jan 29, 2018

Effect of natural compounds curcumin and nicotinamide on α-synuclein accumulation in a C. elegans model of Parkinson’s disease

Parkinson's disease is a neurodegenerative disorder that affects over 10 million people worldwide. It is caused by destruction of dopamine-producing neurons, which results in severe motor and movement symptoms. In this study, the authors investigated the anti-Parkinsonian effects of two natural compounds curcumin and nicotinamide using C. elegans as a model organism.

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The effects of antioxidants on the climbing abilities of Drosophila melanogaster exposed to dental resin

Prashanth et al. | Jan 17, 2019

The effects of antioxidants on the climbing abilities of Drosophila melanogaster exposed to dental resin

Dental resins can be a source of reactive oxygen species (ROS) which in unruly amounts can be toxic to cellular and overall health. In this report, the authors test whether the consumption of antioxidant rich foods like avocado and asparagus can protect against the effect of dental resin-derived ROS. However, rather than testing humans, they use fruit flies and their climbing abilities as an experimental readout.

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The effect of caffeine on the regeneration of Brown Planaria (Dugesia tigrina)

Lazorik et al. | May 10, 2019

The effect of caffeine on the regeneration of Brown Planaria (Dugesia tigrina)

The degeneration of nerve cells in the brain can lead to pathologies such as Parkinson’s disease. It has been suggested that neurons in humans may regenerate. In this study, the effect of different doses of caffeine on regeneration was explored in the planeria model. Caffeine has been shown to enhance dopamine production, and dopamine is found in high concentrations in regenerating planeria tissues. Higher doses of caffeine accelerated planeria regeneration following decapitation, indicating a potential role for caffeine as a treatment to stimulate regeneration.

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