Cystic fibrosis is a genetic disease caused by mutations in the CFTR gene. In this paper, the authors attempt to identify variations in stretches of up to 8 nucleotides in the protein-coding portions of the CFTR gene that are associated with disease development. This would allow screening of newborns or even fetuses in utero to determine the likelihood they develop cystic fibrosis.

The cause of insect colony collapse disorder (CCD) is still a mystery. In this study, the authors aimed to test the effects of two environmental factors, water vapor and smoke levels, on the social behavior and physical condition of insects. Their findings could help shed light on how changing environmental factors can contribute to CCD.

Some spices have antimicrobial or antibacterial properties that people have already tested. Turmeric has a wide variety of uses and has even been implemented in alternative medicine as a treatment for cancer, inflammation, osteoarthritis, and other diseases. We tested the antimicrobial effects of turmeric under two different pHs to characterize this effect in vitro. Decreasing the pH of a solution of turmeric may increase antibacterial properties.

Here, seeking to understand the effects of social media in relation to social media fatigue and/or overload in recent years, the authors used various linear models to assess the results of a survey of 27 respondents. Their results showed that increased duration of use of social media did not necessarily lead to fatigue, suggesting that quality may be more important than quantity. They also considered the purpose of an individual's social media usage as well as their engagement behavior during the COVID-19 pandemic.

Cannabidiol, or CBD, is a widely available over the counter treatment used for various medical conditions. However, CBD exerts its effects on the endocannabinoid system, which is involved in neural maturation, and could potentially have adverse effects on brain development. Here, the impact of CBD on the development of brine shrimp (Artemia salina) was assessed. Differences in dose responses were observed.

Irrespective of the final application of a molecule, synthetic accessibility is the rate-determining step in discovering and developing novel entities. However, synthetic complexity is challenging to quantify as a single metric, since it is a composite of several measurable metrics, some of which include cost, safety, and availability. Moreover, defining a single synthetic accessibility metric for both natural products and non-natural products poses yet another challenge given the structural distinctions between these two classes of compounds. Here, we propose a model for synthetic accessibility of all chemical compounds, inspired by the Central Limit Theorem, and devise a novel synthetic accessibility metric assessing the overall feasibility of making chemical compounds that has been fitted to a Gaussian distribution.

Fertilizers are commonly used to improve agricultural yield. Unfortunately, chemical fertilizers can seep into drinking water, potentially harming humans and other forms of life. Here, the authors investigate the effect of fertilizer on the water quality of Saratoga Creek over time. They find that fertilizers can alter the acidity of the creek's water, which can be harmful to aquatic species, as well as increase the levels of nitrates temporarily.

Long hospital stays can be stressful for the patient for many reasons. We hypothesized that age would be the greatest predictor of hospital stay among patients who underwent orthopedic surgery. Through our models, we found that severity of illness was indeed the highest factor that contributed to determining patient length of stay. The other two factors that followed were the facility that the patient was staying in and the type of procedure that they underwent.

Glioblastoma is a brain cancer caused by the presence of a fast-growing, malignant tumor in the brain. As of now, this cancer is universally lethal due to lack of efficacious treatment options. C-C chemokine receptor 1 (CCR1) is a G-protein coupled receptor that controls chemotaxis, the movement of cells in response to chemical stimuli. This research aims to synthesize potential CCR1 antagonists by coupling carboxylic acids with a triazole core. We synthesized these compounds using a simple carboxylic acid coupling and confirmed the identity of the final compounds using nuclear magnetic resonance (NMR) spectroscopy.

Machine learning algorithms are becoming increasingly popular for data crunching across a vast area of scientific disciplines. Here, the authors compare two machine learning algorithms with respect to accuracy and user-friendliness and find that random forest algorithms outperform logistic regression when applied to the same dataset.