The authors investigate the ability of machine learning models to developing new drug-like molecules by learning desired chemical properties versus simply generating molecules that similar to those in the training set.
Read More...Evaluating the feasibility of SMILES-based autoencoders for drug discovery
The authors investigate the ability of machine learning models to developing new drug-like molecules by learning desired chemical properties versus simply generating molecules that similar to those in the training set.
Read More...Upregulation of the Ribosomal Pathway as a Potential Blood-Based Genetic Biomarker for Comorbid Major Depressive Disorder (MDD) and PTSD
Major Depressive Disorder (MDD), and Post-Traumatic Stress Disorder (PTSD) are two of the fastest growing comorbid diseases in the world. Using publicly available datasets from the National Institute for Biotechnology Information (NCBI), Ravi and Lee conducted a differential gene expression analysis using 184 blood samples from either control individuals or individuals with comorbid MDD and PTSD. As a result, the authors identified 253 highly differentially-expressed genes, with enrichment for proteins in the gene ontology group 'Ribosomal Pathway'. These genes may be used as blood-based biomarkers for susceptibility to MDD or PTSD, and to tailor treatments within a personalized medicine regime.
Read More...Demographic indicators of voter shift between 2016 and 2020 presidential elections
In this study, the authors investigate the demographic indicators for voter shift between the 2016 and 2020 presidential elections based on demographic data put through a K-nearest neighbors classification algorithm and Principal Component Analysis.
Read More...In silico screening of DEAB analogues as ALDH1 isoenzymes inhibitors in cancer treatment
The authors computationally screened potential ALDH1 inhibitors, for use as potential cancer therapeutics.
Read More...Examination of the rotation curve for the dark matter deficient relic galaxy NGC 1277
The authors re-examine the galactic kinematics of relic galaxy NGC 1277, recently identified as dark matter deficient, by reproducing its rotation curve with data from the George and Cynthia Mitchell Spectrograph.
Read More...Simulation of cosmic rays in the presence of a magnetic field
In this study the authors looked the trajectories of cosmic rays moving through a dipole field. They found that the trajectories of cosmic rays are determined by a particle's energy and interaction with Earth's B field.
Read More...An efficient approach to automated geometry diagram parsing
Here, beginning from an initial interest in the possibility to use a computer to automatically solve a geometry diagram parser, the authors developed their own Fast Geometry Diagram Parser (FastGDP) that uses clustering and corner information. They compared their own methods to a more widely available, method, GeoSolver, finding their own to be an order of magnitude faster in most cases that they considered.
Read More...Building a video classifier to improve the accuracy of depth-aware frame interpolation
In this study, the authors share their work on improving the frame rate of videos to reduce data sent to users with both 2D and 3D footage. This work helps improve the experience for both types of footage!
Read More...Predicting Orbital Resonance of 2867 Šteins Using the Yarkovsky Effect
In this study, the impact of thermal effects on the orbit of an asteroid is investigated. This included determining if the asteroid's orbit would push into a region devoid of asteroids due to the gravitational pull of Jupiter.
Read More...Linear and non-linear summation of responses to visual and olfactory cues in male Drosophila melanogaster
In this study, the authors investigate whether phototaxis and odortaxis in Drosophila melanogaster occurs through linear summation of cues including light and attractive odorants.
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