Social media usage is predicted to impact teen well-being and emotional status. This study sought to assess the impact of teen technology usage on their social lives. Surveys of 8th and 9th graders were used to assess compare technology usage between males and females as well as and how social media usage impacts the perception of social environment at school.
Caenorhabditis elegans xpa-1 and him-1 are orthologs of human XPA and human SMC1A, respectively. Mutations in the XPA are correlated with Xeroderma pigmentosum, a condition that induces hypersensitivity to ultraviolet (UV) radiation. Alternatively, SMC1A mutations may lead to Cornelia de Lange Syndrome, a multi-organ disorder that makes patients more sensitive to UVinduced DNA damage. Both C. elegans genes have been found to be involved in protection against UV radiation, but their combined effects have not been tested when they are both knocked down. The authors hypothesized that because these genes are involved in separate pathways, the simultaneous knockdown of both of these genes using RNA interference (RNAi) in C. elegans will cause them to become more sensitive to UV radiation than either of them knocked down individually. UV protection was measured via the percent survival of C. elegans post 365 nm and 5.4x10-19 joules of UV radiation. The double xpa-1/him-1 RNAi knockdown showed a significantly reduced percent survival after 15 and 30 minutes of UV radiation relative to wild-type and xpa-1 and him-1 single knockdowns. These measurements were consistent with their hypothesis and demonstrated that xpa-1 and him-1 genes play distinct roles in resistance against UV stress in C. elegans. This result raises the possibility that the xpa-1/him-1 double knockdown could be useful as an animal model for studying the human disease Xeroderma pigmentosum and Cornelia de Lange Syndrome.
In this study, the authors tested different approaches for removing arsenic from rice. Due to higher arsenic levels in water, some areas grow rice with higher levels as well. This is a health hazard and so developing methods to remove arsenic from the rice will be helpful to many. Using a rapid arsenic kit, the authors found that activated charcoal was the most effective at removing arsenic from rice.
Have you ever wondered what contributes to the popping ability of popcorn? In this study, the authors use Quantitative Trait Locus (QTL) mapping to identify genes that may contribute to specific popping characteristics including kernel size and popping expansion volume (PEV).
High-fructose diets consumed widely in modern societies predisposes to metabolic diseases such as diabetes. Using the worm C. elegans, the authors of this study investigated the effect of fructose on the worm's survival rates. They found that worms fed 15% fructose had a lower life expectancy than those on a fructose-free diet. These results suggest that, like in humans, fructose has a negative effect on worm survival, which makes them an easy, attractive model to study the effects of fructose on health.
Uveal melanoma (UM) is a rare subtype of melanoma but the most frequent primary cancer of the eye in adults. The goal of this study was to research the genetic causes of UM through a comprehensive frequency analysis of base-pair mismatches in patient genomes. Results showed a total of 130 genetic mutations, including seven recurrent mutations, with most mutations occurring in chromosomes 3 and X. Recurrent mutations varied from 8.7% to 17.39% occurrence in the UM patient sample, with all mutations identified as missense. These findings suggest that UM is a recessive heterogeneous disease with selective homozygous mutations. Notably, this study has potential wider significance because the seven genes targeted by recurrent mutations are also involved in other cancers.
In a world where water shortage is becoming an increasing concern, and where population increase seems inevitable, food shortage is an overwhelming concern for many. In this paper, the authors aim to characterize a drought-resistant strain of A. thaliana, investigating the cause for its water resistance. These and similar studies help us learn how plants could be engineered to improve their ability to flourish in a changing climate.
Advancement in DNA sequencing technology has greatly increased our understanding about the role of bacteria in soil. The authors of this study examine the microbial content of soil samples taken from three locations in southern New Hampshire with varying pH and plant composition.
Disruption of the blood-brain barrier (BBB) is related to many neurological disorders, and can be caused by oxidative stress to cerebral microvascular endothelial cells (CMECs) composing the BBB. The authors of the paper investigated the protective effects of the total saponins in the leaves of Panax notoginseng (LPNS) on oxidative-stress-induced damage in a mouse cerebral microvascular endothelial cell line.
Pillai et al. look at whether exposure to Schistosoma mansoni, a parasitic blood fluke, has any relation to peanut allergies. They found that cockroaches exposed to an antigen found in S. mansoni eggs exhibited an allergic reaction to peanuts.