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Modulation of VEGF and TGF beta in 5-FU induced inflammation in MCF-7 using an herbal formulation

Vinay Nair et al. | Jun 03, 2022

Modulation of VEGF and TGF beta in 5-FU induced inflammation in MCF-7 using an herbal formulation

Acquired drug resistance is an increasing challenge in treating cancer with chemotherapy. One mechanism
behind this resistance is the increased inflammation that supports the progression and development of
cancer that arises because of the drug’s presence. Integrative oncology is the field that focuses on including natural products alongside traditional therapy to create a treatment that focuses on holistic patient well-being.
In this study, the authors demonstrate that the use of an herbal formulation, consisting of turmeric and green tea, alongside a traditional chemotherapeutic drug, 5-fluorouracil (FU) significantly decreases the level of cytokines produced in breast cancer cells when compared to the levels produced when exposed solely to the chemo drug. The authors conclude that this combination of treatment, based on the principle of integrative oncology, shows potential for reducing the resistance against treatment conferred through increased inflammation. Consequently, this suggests a prospective way forward in improving the efficacy of cancer treatment.

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Trajectories Between Cigarette Smoking and Electronic Nicotine Delivery System Use Among Adults in the U.S.

Primack et al. | Apr 30, 2020

Trajectories Between Cigarette Smoking and Electronic Nicotine Delivery System Use Among Adults in the U.S.

In this study, the authors characterized the trends of cigarette use amongst people who do and don't use electronic nicotine delivery systems (or ENDS). This was done to help determine if the use of ENDS is aiding in helping smokers quit, as the data on this has been controversial. They found that use of ENDS among people either with or without previous cigarette usage were more likely to continue using cigarettes in the future. This is important information contributing to our understanding of ways to effectively (and not effectively) reduce cigarette use.

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The association between hunting and the feeding and vigilance times of American bison in North Dakota and Montana

McCandless et al. | Mar 30, 2022

The association between hunting and the feeding and vigilance times of American bison in North Dakota and Montana

This study hypothesized that feeding times of bison in the hunted populations would be significantly shorter than that of bison in the nonhunted population and vigilance times would be significantly longer than that of bison in the nonhunted population. Notably, the results found significant differences in feeding and vigilance times of bison in the hunted and non-hunted populations. However, these differences did not support the original hypothesis; bison in hunted populations spent more time feeding and less time vigilant than bison in the non-hunted population. Future studies investigating the association between hunting and bison behaviors could use populations of bison that are hunted more frequently, which may provide different results.

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Detection and Control of Spoilage Fungi in Refrigerated Vegetables and Fruits

Chari et al. | May 16, 2021

Detection and Control of Spoilage Fungi in Refrigerated Vegetables and Fruits

Food spoilage leads to a significant loss in agricultural produce each year. Here, the authors investigate whether certain essential oils can protect against fungus-mediated spoilage of fruits and vegetables. Their results suggest that the compounds they tested might indeed inhibit fungal growth, at various temperatures, a promising result that could reduce food wasting.

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Strain-specific and photochemically-activated antimicrobial activity of berberine and two analogs

Sun et al. | Nov 17, 2020

Strain-specific and photochemically-activated antimicrobial activity of berberine and two analogs

In this study, the authors investigate the antimicrobial effects of berberine and berberine analogs. Berberine is extracted from plants and is a naturally occurring alkaloid, and is also excited photochemically. Using three different assays, the authors tested whether these compounds would inhibit bacterial growth. They found that these compounds were antibacterial and even more so when used with photoirradiation. This study has important antibacterial implications.

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Racial and gender disparities in the portrayal of lawyers and physicians on television

Asadi et al. | Nov 18, 2022

Racial and gender disparities in the portrayal of lawyers and physicians on television

Powered by the sociological framework that exposure to television bleeds into social biases, limiting media representation of women and minority groups may lead to real-world implications and manifestations of racial and gender disparities. To address this phenomenon, the researchers in this article take a look at primetime fictional representation of minorities and women as lawyers and physicians and compare television representation to census data of the same groups within real-world legal and medical occupations. The authors maintain the hypothesis that representation of female and minority groups as television lawyers and doctors is lower than that of their white male counterparts relative to population demographics - a trend that they expect to also be reflected in actual practice. With fictional racial and gender inequalities and corresponding real-world trends highlighted within this article, the researchers call for address towards representation biases that reinforce each other in both fictional and non-fictional spheres.

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Grammatical Gender and Politics: A Comparison of French and English in Political Discourse

Zhang et al. | Jul 07, 2021

Grammatical Gender and Politics: A Comparison of French and English in Political Discourse

Grammatical gender systems are prevalent across many languages, and when comparing French and English the existence of this system becomes a strong distinction. There have been studies that attribute assigned grammatical gender with the ability to influence conceptualization (attributing gender attributes) of all nouns, thus affecting people's thoughts on a grand scale. We hypothesized that due to the influence of a grammatical gender system, French political discourse would have a large difference between the number of masculine and feminine nouns used. Specifically, we predicted there would be a larger ratio of feminine to masculine nouns in French political discourse than in non-political discourse when compared to English discourse. Through linguistic analysis of gendered nouns in French political writing, we found that there is a clear difference between the number of feminine versus masculine nouns, signaling a preference for a more “effeminate” language.

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