Browse Articles

The effects of the cancer metastasis promoting gene CD151 in E. coli

Burgess et al. | Jun 11, 2023

The effects of the cancer metastasis promoting gene <i>CD151</i> in <i>E. coli</i>
Image credit: qimono

The independent effects of metastasis-promoting gene CD151 in the process of metastasis are not known. This study aimed to isolate CD151 to discover what its role in metastasis would be uninfluenced by potential interactions with other components and pathways in human cells. Results showed that CD151 significantly increased the adhesion of the cells and decreased their motility. Thus, it may be that CD151 is upregulated in cancer cells for the last step of metastasis, and it increases the chances of success of metastasis by aiding in implantation of the cancer cells. Targeting CD151 in chemotherapeutic modalities could therefore potentially slow or prevent metastasis.

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AeroPurify: Autonomous air filtration UAV using real-time 3-D Monte Carlo gradient search

Kadakia et al. | Sep 01, 2025

AeroPurify: Autonomous air filtration UAV using real-time 3-D Monte Carlo gradient search
Image credit: Ian Usher

Here the authors present an autonomous drone air filtration system that uses a novel algorithm, the gradient ascent ML particle filter (GA/MLPF), to efficiently locate and mitigate outdoor air pollution. They demonstrate that their GA/MLPF algorithm is significantly more efficient than the conventional gradient ascent algorithm, reducing both the time and number of waypoints needed to find the source of pollution.

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Substance Abuse Transmission-Impact of Parental Exposure to Nicotine/Alcohol on Regenerated Planaria Offspring

Bennet et al. | Jul 02, 2024

Substance Abuse Transmission-Impact of Parental Exposure to Nicotine/Alcohol on Regenerated Planaria Offspring

The global mental health crisis has led to increased substance abuse among youth. Prescription drug abuse causes approximately 115 American deaths daily. Understanding intergenerational transmission of substance abuse is complex due to lengthy human studies and socioeconomic variables. Recent FDA guidelines mandate abuse liability testing for neuro-active drugs but overlook intergenerational transfer. Brown planaria, due to their nervous system development similarities with mammals, offer a novel model.

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Effect of hypervitaminosis A in regenerating planaria: A potential model for teratogenicity testing

Bennet et al. | Dec 12, 2022

Effect of hypervitaminosis A in regenerating planaria: A potential model for teratogenicity testing

This unique research study evaluated the potential use of the flatworm, brown planaria (Dugesia tigrine), as an alternative model for teratogenicity testing. In this study, we exposed amputated planaria to varying concentrations of a known teratogen, vitamin A (retinol), for approximately 2 weeks, and evaluated multiple parameters including the formation of blastema and eyes. The results from this study demonstrated that high concentrations of retinol caused defects in head and eye formation in regenerating planaria, with similarities to vitamin A related teratogenicity findings in mammals. Based on these results, regenerating brown planaria are a promising alternative model for teratogenicity testing, which can potentially be paradigm shifting as it can reduce cost, time, and pregnant animal use in research.

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In vitro Comparison of Anticancer and Immunomodulatory Activities of Resveratrol and its Oligomers

Zhang et al. | Sep 02, 2020

<em>In vitro</em> Comparison of Anticancer and Immunomodulatory Activities of Resveratrol and its Oligomers

Resveratrol is a type of stillbenoid, a phenolic compound produced in plants, that is known for its anti-inflammatory and anticancer effects. Many oligomers of resveratrol have recently been isolated their bioactivities remain unknown. Here, authors compared the bioactivities of resveratrol with natural dimers (ε-viniferin and gnetin H) and trimers (suffruticosol B and C). Results provide preliminary evidence that resveratrol oligomers could be potential preventive or therapeutic agents for cancers and other immune-related diseases

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