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The Effect of Different Concentrations of Iron on the Growth of Egeria (Elodea) Densa

Hu et al. | Jan 08, 2015

The Effect of Different Concentrations of Iron on the Growth of <em>Egeria (Elodea) Densa</em>

Minerals such as iron are essential for life, but too much of a good thing can be poisonous. Here the authors investigate the effect of iron concentrations on the growth of an aquatic plant and find that supplementing small amounts of iron can help, but adding too much can be bad for the plant. These results should help inform decisions on allowable iron concentrations in the environment, aquatic farming, and even home aquariums.

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Combinatorial treatment by siNOTCH and retinoic acid decreases A172 brain cancer cell growth

Richardson et al. | Nov 14, 2022

Combinatorial treatment by siNOTCH and retinoic acid decreases A172 brain cancer cell growth

Treatments inhibiting Notch signaling pathways have been explored by researchers as a new approach for the treatment of glioblastoma tumors, which is a fast-growing and aggressive brain tumor. Recently, retinoic acid (RA) therapy, which inhibits Notch signaling, has shown a promising effect on inhibiting glioblastoma progression. RA, which is a metabolite of vitamin A, is very important in embryonic cellular development, which includes the regulation of multiple developmental processes, such as brain neurogenesis. However, high doses of RA treatment caused many side effects such as headaches, nausea, redness around the injection site, or allergic reactions. Therefore, we hypothesized that a combination treatment of RA and siRNA targeting NOTCH1 (siNOTCH1), the essential gene that activates Notch signaling, would effectively inhibit brain cancer cell proliferation. The aim of the study was to determine whether inhibiting NOTCH1 would inhibit the growth of brain cancer cells by cell viability assay. We found that the combination treatment of siNOTCH1 and RA in low concentration effectively decreased the NOTCH1 expression level compared to the individual treatments. However, the combination treatment condition significantly decreased the number of live brain cancer cells only at a low concentration of RA. We anticipate that this novel combination treatment can provide a solution to the side effects of chemotherapy.

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Aggression of Carcharhinus leucas and Carcharhinus amblyrhynchos towards humans

Mignone et al. | May 11, 2021

Aggression of <i>Carcharhinus leucas</i> and <i>Carcharhinus amblyrhynchos</i> towards humans

This paper presents findings on Carcharhinus leucas (bull shark) and Carcharhinus amblyrhynchos (grey reef shark) aggression towards humans at Beqa Adventure Divers in Shark Reef Marine Reserve, Fiji. We hypothesized that grey reef sharks would receive more prods than bull sharks because grey reef sharks are typically more aggressive than bull sharks. The results supported our hypothesis, as an individual grey reef shark received 2.44 prods on average per feed, while a bull shark had an average of 0.61. These findings are meaningful not only to the world’s general understanding of shark aggression, but also to human protection against grey reef sharks as well as public education on bull sharks and the conservation of the species.

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A machine learning approach for abstraction and reasoning problems without large amounts of data

Isik et al. | Jun 25, 2022

A machine learning approach for abstraction and reasoning problems without large amounts of data

While remarkable in its ability to mirror human cognition, machine learning and its associated algorithms often require extensive data to prove effective in completing tasks. However, data is not always plentiful, with unpredictable events occurring throughout our daily lives that require flexibility by artificial intelligence utilized in technology such as personal assistants and self-driving vehicles. Driven by the need for AI to complete tasks without extensive training, the researchers in this article use fluid intelligence assessments to develop an algorithm capable of generalization and abstraction. By forgoing prioritization on skill-based training, this article demonstrates the potential of focusing on a more generalized cognitive ability for artificial intelligence, proving more flexible and thus human-like in solving unique tasks than skill-focused algorithms.

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