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Ramifications of natural and artificial sweeteners on the gastrointestinal system

Cowen et al. | Jun 19, 2023

Ramifications of natural and artificial sweeteners on the gastrointestinal system

This study aimed to determine whether artificial sweeteners are harmful to the human microbiome by investigating two different bacteria found to be advantageous to the human gut, Escherichia coli and Bacillus coagulans. Results showed dramatic reduction in bacterial growth for agar plates containing two artificial sweeteners in comparison to two natural sweeteners. This led to the conclusion that both artificial sweeteners inhibit the growth of the two bacteria and warrants further study to determine if zero-sugar sweeteners may be worse for the human gut than natural sugar itself.

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A study to determine the anti-cancer and pro-apoptotic properties of Amaranthus spinosus Linn. Extract, AS20

Sharma et al. | Nov 24, 2020

A study to determine the anti-cancer and pro-apoptotic properties of Amaranthus spinosus Linn. Extract, AS20

In this study, the authors investigate whether a new compound has anti-cancer properties. Using the crude extract from the Amaranthus spinosus plant, HeLa cancer cells were assessed for cell death. Findings reveal that the extract (AS20) has cytotoxic effects on HeLa cells. Their findings introduce a new compound to potentially pursue in the hunt for novel cancer treatments.

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Integrated Ocean Cleanup System for Sustainable and Healthy Aquatic Ecosystems

Anand et al. | Nov 14, 2020

Integrated Ocean Cleanup System for Sustainable and Healthy Aquatic Ecosystems

Oil spills are one of the most devastating events for marine life. Finding ways to clean up oil spills without the need for harsh chemicals could help decrease the negative impact of such spills. Here the authors demonstrate that using a combination of several biodegradable substances can effectively adsorb oil in seawater in a laboratory setting. They suggest further exploring the potential of such a combination as a possible alternative to commonly-used non-biodegradable substances in oil spill management.

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Creating a Phenology Trail Around Central Park Pond

Flynn et al. | Jul 16, 2020

Creating a Phenology Trail Around Central Park Pond

This study aimed to determine whether the life cycle stages, or phenophases, of some plants in the urban environment of Central Park, New York, differ from the typical phenophases of the same plant species. The authors hypothesized that the phenophases of the thirteen plants we studied would differ from their typical phenophases due to the urban heat island effect. Although the phenophases of five plants matched up with typical trends, there were distinct changes in the phenophases of the other eight, possibly resulting from the urban heat island effect.

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The Bioactive Ingredients in Niuli Lactucis Agrestibus Possess Anticancer Effects

Zhu et al. | Sep 17, 2019

The Bioactive Ingredients in Niuli Lactucis Agrestibus Possess Anticancer Effects

In​ the​ field​ of​ medicine,​ natural​ treatments​ are​ becoming ​increasingly ​vital ​towards ​the ​cure ​of ​cancer. Zhu et al. wanted to investigate the effects of lettuce extract on cancer cell survival and proliferation. They used an adenocarcinoma cell line, COLO320DM, to determine whether crude extract from a lettuce species called Niuli​ Lactucis Agrestibus​ would affect cancer cell survival, migration, and proliferation. They found that Niuli extract inhibited cancer cell survival, increased expression of cell cycle inhibitors p21 and p27, and inhibited migration. However, Niuli extract did not have these effects on healthy cells. This work reveals important findings about a potential new source of anti-colorectal cancer compounds.

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The Cilium- and Centrosome-Associated Protein CCDC11 Is Required for Cytokinesis via Midbody Recruitment of the ESCRT- III Membrane Scission Complex Subunit CHMP2A

Ahmed et al. | Mar 14, 2018

The Cilium- and Centrosome-Associated Protein CCDC11 Is Required for Cytokinesis via Midbody Recruitment of the ESCRT- III Membrane Scission Complex Subunit CHMP2A

In order for cells to successfully multiply, a number of proteins are needed to correctly coordinate the replication and division process. In this study, students use fluorescence microscopy and molecular methods to study CCDC11, a protein critical in the formation of cilia. Interestingly, they uncover a new role for CCDC11, critical in the cell division across multiple human cell lines.

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Impact of gadodiamide (Omniscan) on a beef liver catalase ex vivo model

Hirsch et al. | Mar 10, 2023

Impact of gadodiamide (Omniscan) on a beef liver catalase <em>ex vivo</em> model
Image credit: Marcelo Leal

Here, seeking to better understand the effects of gadolinium-based contrast agents, dyes typically used for MRI scans, the authors evaluated the activity of catalase found in beef liver both with and without gadodiamide when exposed to hydrogen peroxide. They found that gadioamide did not significantly inhibit catalase's activity, attributing this lack of effects to the chelating agent found in gadodiamide.

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