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Glioblastoma is a brain cancer caused by the presence of a fast-growing, malignant tumor in the brain. As of now, this cancer is universally lethal due to lack of efficacious treatment options. C-C chemokine receptor 1 (CCR1) is a G-protein coupled receptor that controls chemotaxis, the movement of cells in response to chemical stimuli. This research aims to synthesize potential CCR1 antagonists by coupling carboxylic acids with a triazole core. We synthesized these compounds using a simple carboxylic acid coupling and confirmed the identity of the final compounds using nuclear magnetic resonance (NMR) spectroscopy.

In this study the authors looked at developing a more efficient particle collision classification method with the goal of being able to more efficiently analyze particle trajectories from large-scale particle collisions without loss of accuracy.

In this study, the authors explore contrast-enhanced magnetic resonance imaging at Earth's field.

Here, the authors used machine learning to analyze microscopic images of hair, quantifying various features to distinguish individuals, even within families where traditional DNA analysis is limited. The Discriminant Analysis (DA) model achieved the highest accuracy (88.89%) in identifying individuals, demonstrating its potential to improve the reliability of hair evidence in forensic investigations.

Disruption of the blood-brain barrier (BBB) is related to many neurological disorders, and can be caused by oxidative stress to cerebral microvascular endothelial cells (CMECs) composing the BBB. The authors of the paper investigated the protective effects of the total saponins in the leaves of Panax notoginseng (LPNS) on oxidative-stress-induced damage in a mouse cerebral microvascular endothelial cell line.

In this study, the authors identify transcripts and gene networks that are changed after infection with the Middle East Respiratory Syndrome-related coronavirus (MERS-CoV).

Here, the authors characterize how silver ions nucleate a star-block copolymer to generate nano-sized silver particles.

In this study, the authors determined whether tautomerization dynamics in protic and aprotic solvents displayed differences in reaction rates and in the proportion of the keto and enol tautomers present.