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A Novel Alzheimer's Disease Therapeutic Model: Attenuating Hyperphosphorylated Tau and Amyloid β (Aβ) Aggregates by Characterizing Antioxidative, Anti-Inflammatory, and Neuroprotective Properties of Natural Extracts

Pokkunuri et al. | Jul 25, 2022

A Novel Alzheimer's Disease Therapeutic Model: Attenuating Hyperphosphorylated Tau and Amyloid β (Aβ) Aggregates by Characterizing Antioxidative, Anti-Inflammatory, and Neuroprotective Properties of Natural Extracts

Oxidative damage and neuro-inflammation were the key pathways implicated in the pathogenesis of Alzheimer’s disease. In this study, 30 natural extracts from plant roots and leaves with extensive anti-inflammatory and anti-oxidative properties were consumed by Drosophila melanogaster. Several assays were performed to evaluate the efficacy of these combinational extracts on delaying the progression of Alzheimer’s disease. The experimental group showed increased motor activity, improved associative memory, and decreased lifespan decline relative to the control group.

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A Novel Approach to Prevent and Restrict Early Stages of Cancer Cell Growth Using a Combination of Moringa and Sesame in a Drosophila Model

Ganesh et al. | Sep 28, 2020

A Novel Approach to Prevent and Restrict Early Stages of Cancer Cell Growth Using a Combination of Moringa and Sesame in a <em>Drosophila</em> Model

Sesame (Sesamum indicum) and moringa (Moringa oleifera) have natural antioxidants that could prevent cancer growth. Previously, this group found that sesame and moringa individually suppress eye tumor grown in the Drosophila melanogaster model. In the present study, combinations of sesame and moringa at different concentrations were included in the D. melanogaster diet. The impact on eye tumor development was assessed at different stages of growth.

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A novel deep learning model for visibility correction of environmental factors in autonomous vehicles

Dey et al. | Oct 31, 2022

A novel deep learning model for visibility correction of environmental factors in autonomous vehicles

Intelligent vehicles utilize a combination of video-enabled object detection and radar data to traverse safely through surrounding environments. However, since the most momentary missteps in these systems can cause devastating collisions, the margin of error in the software for these systems is small. In this paper, we hypothesized that a novel object detection system that improves detection accuracy and speed of detection during adverse weather conditions would outperform industry alternatives in an average comparison.

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Solubility of graphite and the efficacy of using its dissolved form as a conductive paste

Kirby et al. | Aug 23, 2024

Solubility of graphite and the efficacy of using its dissolved form as a conductive paste

This study explored the use of graphite's conductivity for circuit boards by creating a conductive paste through exfoliation with organic solvents and sonication. The combination of acetone and sonication was found to be the most effective, producing a high-conductivity paste with desirable properties such as a low boiling point. While not a replacement for wires, this conductive paste has potential applications in electronics and infrastructure, provided that key engineering challenges are addressed.

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Rhizosphere metagenome analysis and wet-lab approach to derive optimal strategy for lead remediation in situ

Bhat et al. | Jul 18, 2023

Rhizosphere metagenome analysis and wet-lab approach to derive optimal strategy for lead remediation <i>in situ</i>
Image credit: Karolina Grabowska

The Environmental Protection Agency (EPA) reports a significant number of heavy metal-contaminated sites across the United States. To address this public health concern, rhizoremediation using microbes has emerged as a promising solution. Here, a combination of soil microbes were inoculated in the rhizosphere in soil contaminated with 500 parts per million (ppm) of lead. Results showed rhizoremediation is an effective bioremediation strategy and may increase crop productivity by converting nonarable lands into arable lands.

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Racemic serine is less soluble than pure enantiomers due to stronger intermolecular hydrogen bonds

Ranka et al. | Nov 18, 2021

Racemic serine is less soluble than pure enantiomers due to stronger intermolecular hydrogen bonds

Seeking to develop a better understanding of the chemical and physical properties of amino acids that compose proteins, here the authors investigated the unusual relative insolubility of racemic mixtures of D- and L-serine compared to the solubility of pure D- or L-serine. The authors used a combination of microscopy and temperature measurements alongside previous X-ray diffraction studies to conclude that racemic DL-serine crystals consist of comparatively stronger hydrogen bond interactions compared to crystals of pure enantiomers. These stronger interactions were found to result in the unique release of heat during the crystallization of racemic mixtures.

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Zinc-related Treatments Combined with Chloroquine and Gemcitabine for Treating Pancreatic Cancer

Ma et al. | Sep 11, 2021

Zinc-related Treatments Combined with Chloroquine and Gemcitabine for Treating Pancreatic Cancer

Pancreatic cancer is one of the deadliest cancers, with a 10% 5-year survival rate. The authors studied various dosages of TPEN and zinc in combination with Chloroquine and Gemcitabine as treatments to reduce cell proliferation. Results showed that when combined with Chloroquine and Gemcitabine, zinc and TPEN both significantly lowered cell proliferation compared to Gemcitabine, suggesting a synergistic effect that resulted in a more cytotoxic treatment. Further research and clinical trials on this topic are needed to determine whether this could be a viable treatment for pancreatic cancer.

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Integrated Ocean Cleanup System for Sustainable and Healthy Aquatic Ecosystems

Anand et al. | Nov 14, 2020

Integrated Ocean Cleanup System for Sustainable and Healthy Aquatic Ecosystems

Oil spills are one of the most devastating events for marine life. Finding ways to clean up oil spills without the need for harsh chemicals could help decrease the negative impact of such spills. Here the authors demonstrate that using a combination of several biodegradable substances can effectively adsorb oil in seawater in a laboratory setting. They suggest further exploring the potential of such a combination as a possible alternative to commonly-used non-biodegradable substances in oil spill management.

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Assaying the Formation of Beneficial Biofilms by Lactic Acid Bacteria and the Effect of Ayurvedic Plant Extracts on Their Enhancement

Rajpal et al. | Oct 12, 2017

Assaying the Formation of Beneficial Biofilms by Lactic Acid Bacteria and the Effect of Ayurvedic Plant Extracts on Their Enhancement

This study aimed to obtain an optimal non-antibiotic method to suppress the growth of pathogenic bacteria within the body. The two-fold purpose of this project was to determine which combination of bacteria would result in the most biofilm formation and then to assess the effect of ayurvedic plant extracts on the biofilm. The results show that the addition of a plant extract can affect the biofilm growth of a bacteria combination. The applications of this study can be used to design probiotic supplements with added beneficial plant extracts.

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