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Singlet oxygen production analysis of reduced berberine analogs via NMR spectroscopy

Su et al. | Feb 10, 2023

Singlet oxygen production analysis of reduced berberine analogs via NMR spectroscopy

Berberine is a natural product isoquinoline alkaloid derived from plants of the genus Berberis. When exposed to photoirradiation, it produces singlet oxygen through photosensitization of triplet oxygen. Through qNMR analysis of 1H NMR spectra gathered through kinetic experiments, we were able to track the generation of a product between singlet oxygen and alpha terpinene, allowing us to quantitatively measure the photosensitizing properties of our scaffolds.

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Analysis of reduction potentials to determine the most efficient metals for electrochemical cell alternatives

Carroll et al. | Jul 10, 2020

Analysis of reduction potentials to determine the most efficient metals for electrochemical cell alternatives

In this study, the authors investigate what metals make the most efficient electrochemical cells, which are batteries that use the difference in electrical potential to generate electricity. Calculations predicted that a cell made of iron and magnesium would have the highest efficiency. Construction of an electrochemical cell of iron and magnesium produced voltages close to the theoretical voltage predicted. These findings are important as work continues towards making batteries with the highest storage efficiency possible.

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Factors Influencing Muon Flux and Lifetime: An Experimental Analysis Using Cosmic Ray Detectors

Samson et al. | May 18, 2020

Factors Influencing Muon Flux and Lifetime: An Experimental Analysis Using Cosmic Ray Detectors

Muons, one of the fundamental elementary particles, originate from the collision of cosmic rays with atmospheric particles and are also generated in particle accelerator collisions. In this study, Samson et al analyze the factors that influence muon flux and lifetime using Cosmic Ray Muon Detectors (CRMDs). Overall, the study suggests that water can be used to decrease muon flux and that scintillator orientation is a potential determinant of the volume of data collected in muon decay studies.

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Comparative analysis of CO2 emissions of electric ride-hailing vehicles over conventional gasoline personal vehicles

Raman et al. | Jan 12, 2024

Comparative analysis of CO<sub>2</sub> emissions of electric ride-hailing vehicles over conventional gasoline personal vehicles
Image credit: Paul Hanaoka

While some believe that ride-hailing services offer reduced CO2 emissions compared to individual driving, studies have found that driving without passengers on ride-hailing trips or "deadheading" prevents this. Here, with a mathematical model, the authors investigated if the use of electric vehicles as ride-hailing vehicles could offer reduced CO2 emissions. They found that the improved vehicle efficiency and cleaner generation could in fact lower emissions compared to the use of personal gas vehicles.

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Building an affordable model wave energy converter using a magnet and a coil

Choy et al. | Jul 05, 2023

Building an affordable model wave energy converter using a magnet and a coil
Image credit: Joshua Smith

Here, seeking to identify a method to locally produce and capture renewable energy in Hawai'i and other island communities, the authors built and tested a small-scale model wave energy converter. They tested various configurations of a floated magnet surrounded by a wire coal, where the motion of the magnet due to a wave results in induction current in the coil. While they identified methods to increase the voltage and current generated, they also found that corrosion results in significant deterioration.

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QuitPuff: A Simple Method Using Saliva to Assess the Risk of Oral Pre-Cancerous Lesions and Oral Squamous Cell Carcinoma in Chronic Smokers

Shamsher et al. | Mar 27, 2019

QuitPuff: A Simple Method Using Saliva to Assess the Risk of Oral Pre-Cancerous Lesions and Oral Squamous Cell Carcinoma in Chronic Smokers

Smoking generates free radicals and reactive oxygen species which induce cell damage and lipid peroxidation. This is linked to the development of oral cancer in chronic smokers. The authors of this study developed Quitpuff, simple colorimetric test to measure the extent of lipid peroxidation in saliva samples. This test detected salivary lipid peroxidation with 96% accuracy in test subjects and could serve as an inexpensive, non-invasive test for smokers to measure degree of salivary lipid peroxidation and potential risk of oral cancer.

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DyGS: A Dynamic Gene Searching Algorithm for Cancer Detection

Wang et al. | Jun 05, 2018

DyGS: A Dynamic Gene Searching Algorithm for Cancer Detection

Wang and Gong developed a novel dynamic gene-searching algorithm called Dynamic Gene Search (DyGS) to create a gene panel for each of the 12 cancers with the highest annual incidence and death rate. The 12 gene panels the DyGS algorithm selected used only 3.5% of the original gene mutation pool, while covering every patient sample. About 40% of each gene panel is druggable, which indicates that the DyGS-generated gene panels can be used for early cancer detection as well as therapeutic targets in treatment methods.

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Use of yogurt bacteria as a model surrogate to compare household cleaning solutions

Shukla et al. | May 07, 2023

Use of yogurt bacteria as a model surrogate to compare household cleaning solutions
Image credit: CDC

While resources on the safety of household cleaning products are plentiful, measures of efficacy of these cleaning chemicals against bacteria and viruses remain without standardization in the consumer market. The COVID pandemic has exasperated this knowledge gap, stoking the growth of misinformation and misuse surrounding household cleaning chemicals. Arriving at a time dire for sanitization standardization, the authors of this paper have created a quantifying framework for consumers by comparing a wide range of household cleaning products in their efficacy against bacteria generated by a safe and easily replicable yogurt model.

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Fingerprint patterns through genetics

O'Brien et al. | Dec 02, 2020

Fingerprint patterns through genetics

This study explores the link between fingerprints and genetics by analyzing familial fingerprints to show how the fingerprints between family members, and in particular siblings, could be very similar. The hypothesis was that the fingerprints between siblings would be very similar and the dominant fingerprint features within the family would be the same throughout the generations. Fingerprints between the siblings showed a trend of similarity, with only very small differences which makes these fingerprints unique. This work helps to support the link between fingerprints and genetics while providing a modern technological application.

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Ant Colony Optimization Algorithms with Multiple Simulated Colonies Offer Potential Advantages for Solving the Traveling Salesman Problem and, by Extension, Other Optimization Problems

Wildenhain et al. | May 22, 2015

Ant Colony Optimization Algorithms with Multiple Simulated Colonies Offer Potential Advantages for Solving the Traveling Salesman Problem and, by Extension, Other Optimization Problems

Ant colony optimization algorithms simulate ants moving from point to point on a graph and coordinate their actions, similar to ants laying down pheromones to strengthen a path as it is used more frequently. These ACO algorithms can be applied to the classic traveling salesman problem, which aims to determine the lowest-cost path through a given set of points on a graph. In this study, a novel multiple-colony system was developed that uses multiple simulated ant colonies to generate improved solutions to the traveling salesman problem.

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