Browse Articles

Development of selective RAC1/KLRN inhibitors

Kubrat Neczaj-Hruzewicz et al. | Nov 04, 2024

Development of selective RAC1/KLRN inhibitors

Kalirin is a guanine nucleotide exchange factor (GEF) for the GTPase RAC1, linked to schizophrenia and Alzheimer’s Disease. It plays a crucial role in synaptic plasticity by regulating dendritic spine formation and actin cytoskeleton remodeling, which are essential for creating new synapses. Authors developed two novel compounds targeting kalirin, confirming that predictive modeling can indicate biological activity.

Read More...

Risk factors contributing to Pennsylvania childhood asthma

Li et al. | Oct 30, 2024

Risk factors contributing to Pennsylvania childhood asthma
Image credit: The authors

Asthma is one of the most prevalent chronic conditions in the United States. But not all people experience asthma equally, with factors like healthcare access and environmental pollution impacting whether children are likely to be hospitalized for asthma's effects. Li, Li, and Ruffolo investigate what demographic and environmental factors are predictive of childhood asthma hospitalization rates across Pennsylvania.

Read More...

Public Perception of the Effects of Artificial Sweeteners on Diabetes Based on YouTube Comments

Kim et al. | Jun 25, 2024

Public Perception of the Effects of Artificial Sweeteners on Diabetes Based on YouTube Comments
Image credit: The authors

Artificial sweeteners are rising in popularity, in part due to the influence of social media platforms like YouTube. However, YouTube commenters often repeat information about artificial sweeteners that is not supported by scientific research. To investigate how misinformation about sweeteners spreads through social media, Kim and Yoo conduct a content analysis of YouTube comments to reveal how many comments repeat misinformation about artificial sweeteners' effects.

Read More...

The effect of sports on teenagers’ depression symptoms during the COVID-19 pandemic

Düzgezen et al. | Jun 12, 2023

The effect of sports on teenagers’ depression symptoms during the COVID-19 pandemic
Image credit: Izuddin Helmi Adnan

Here, seeking to identify the possible role of sports in helping teenagers navigate the troubles associated with societal changes during a pandemic, the authors surveyed 50 adolescents to collect Beck Depression Inventory scores. They found that 9 out of students with severe depressions did not do sports, while no significant relationship between depressive symptoms and either gender or place of exercise was observed.

Read More...