This study uses neuroimaging to investigate cognitive set-shifting, a type of executive function that involves shifting from one task to another. This study tested whether cortical gray-white matter contrast in subregions of the prefrontal cortex (PFC) was associated with set-shifting abilities in adults.
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Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1
Polo-like kinase 1 (Plk1) is a master regulator of mitosis, initiating key steps of cell cycle regulation, and its overexpression is associated with certain types of cancer. In this study, the authors carefully designed peptides that were able to bind to Plk1 at a location that is important for its proper localization and function. Future studies could further develop these peptides to selectively target Plk1 in cancer cells and induce mitotic arrest.
Read More...Using a Risk Assessment Questionnaire to Identify Prediabetics and Diabetics in Tandag, Philippines
Diabetes is a growing health concern in the developing world. This study aimed to develop a questionnaire that uses factors including age, blood pressure, BMI, and family history to predict whether Filipino participants are at risk for diabetes.
Read More...Pancreatic Adenocarcinoma: An Analysis of Drug Therapy Options through Interaction Maps and Graph Theory
Cancer is often caused by improper function of a few proteins, and sometimes it takes only a few proteins to malfunction to cause drastic changes in cells. Here the authors look at the genes that were mutated in patients with a type of pancreatic cancer to identify proteins that are important in causing cancer. They also determined which proteins currently lack effective treatment, and suggest that certain proteins (named KRAS, CDKN2A, and RBBP8) are the most important candidates for developing drugs to treat pancreatic cancer.
Read More...A natural language processing approach to skill identification in the job market
The authors looked at using machine learning to identify skills needed to apply for certain jobs, specifically looking at different techniques to parse apart the text. They found that Bidirectional Encoder Representation of Transforms (BERT) performed best.
Read More...The correlation between bacteria and colorectal cancer
The authors looked at abundance of bacteria in stool samples from patients with colorectal cancer compared to controls. They found different bacteria that was more prevalent in patients with colorectal cancer as well as bacteria in control patients that may indicate a beneficial gut microbiome.
Read More...Epileptic seizure detection using machine learning on electroencephalogram data
The authors use machine learning and electroencephalogram data to propose a method for improving epilepsy diagnosis.
Read More...Adults’ attitudes toward non-alcoholic beer purchases and consumption by children and adolescents
Consumption of non-alcoholic beverages, like non-alcoholic beer, is growing in popularity in the United States. These beverages raise important societal questions, such as whether minors should be allowed to purchase or consume non-alcoholic beer. An and An investigate this issue by surveying adults to see if they support minors purchasing and consuming non-alcoholic beer.
Read More...High school students’ attitudes towards diverse cultures and ethnicities
The authors looked at how a student's own background influence their attitude towards integration of diverse cultures and ethnicities. While overall students viewed other groups positively, the authors found that groups still indicated they felt judged by their peers.
Read More...The effect of molecular weights of chitosan on the synthesis and antifungal effect of copper chitosan
Pathogenic fungi such as Alternaria alternata (A. alternata) can decimate crop yields and severely limit food supplies when left untreated. Copper chitosan (CuCts) is a promising alternative fungicide for developing agricultural areas due to being inexpensive and nontoxic. We hypothesized that LMWc CuCts would exhibit greater fungal inhibition due to the beneficial properties of LMWc.
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