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Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1

Jang et al. | Aug 19, 2016

Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1

Polo-like kinase 1 (Plk1) is a master regulator of mitosis, initiating key steps of cell cycle regulation, and its overexpression is associated with certain types of cancer. In this study, the authors carefully designed peptides that were able to bind to Plk1 at a location that is important for its proper localization and function. Future studies could further develop these peptides to selectively target Plk1 in cancer cells and induce mitotic arrest.

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Pancreatic Adenocarcinoma: An Analysis of Drug Therapy Options through Interaction Maps and Graph Theory

Gupta et al. | Feb 04, 2014

Pancreatic Adenocarcinoma: An Analysis of Drug Therapy Options through Interaction Maps and Graph Theory

Cancer is often caused by improper function of a few proteins, and sometimes it takes only a few proteins to malfunction to cause drastic changes in cells. Here the authors look at the genes that were mutated in patients with a type of pancreatic cancer to identify proteins that are important in causing cancer. They also determined which proteins currently lack effective treatment, and suggest that certain proteins (named KRAS, CDKN2A, and RBBP8) are the most important candidates for developing drugs to treat pancreatic cancer.

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The correlation between bacteria and colorectal cancer

Zhang et al. | Oct 21, 2024

The correlation between bacteria and colorectal cancer

The authors looked at abundance of bacteria in stool samples from patients with colorectal cancer compared to controls. They found different bacteria that was more prevalent in patients with colorectal cancer as well as bacteria in control patients that may indicate a beneficial gut microbiome.

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Adults’ attitudes toward non-alcoholic beer purchases and consumption by children and adolescents

An et al. | Aug 23, 2024

Adults’ attitudes toward non-alcoholic beer purchases and consumption by children and adolescents
Image credit: The authors

Consumption of non-alcoholic beverages, like non-alcoholic beer, is growing in popularity in the United States. These beverages raise important societal questions, such as whether minors should be allowed to purchase or consume non-alcoholic beer. An and An investigate this issue by surveying adults to see if they support minors purchasing and consuming non-alcoholic beer.

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The effect of molecular weights of chitosan on the synthesis and antifungal effect of copper chitosan

Byakod et al. | Apr 07, 2024

The effect of molecular weights of chitosan on the synthesis and antifungal effect of copper chitosan

Pathogenic fungi such as Alternaria alternata (A. alternata) can decimate crop yields and severely limit food supplies when left untreated. Copper chitosan (CuCts) is a promising alternative fungicide for developing agricultural areas due to being inexpensive and nontoxic. We hypothesized that LMWc CuCts would exhibit greater fungal inhibition due to the beneficial properties of LMWc.

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