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Computational Structure-Activity Relationship (SAR) of Berberine Analogs in Double-Stranded and G-Quadruplex DNA Binding Reveals Both Position and Target Dependence

Sun et al. | Dec 18, 2020

Computational Structure-Activity Relationship (SAR) of Berberine Analogs in Double-Stranded and G-Quadruplex DNA Binding Reveals Both Position and Target Dependence

Berberine, a natural product alkaloid, and its analogs have a wide range of medicinal properties, including antibacterial and anticancer effects. Here, the authors explored a library of alkyl or aryl berberine analogs to probe binding to double-stranded and G-quadruplex DNA. They determined that the nature of the substituent, the position of the substituent, and the nucleic acid target affect the free energy of binding of berberine analogs to DNA and G-quadruplex DNA, however berberine analogs did not result in net stabilization of G-quadruplex DNA.

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Developing a Portable, Reusable, and Inexpensive Magnesium-Air Fuel Cell

Tota et al. | Mar 28, 2019

Developing a Portable, Reusable, and Inexpensive Magnesium-Air Fuel Cell

One of the greatest challenges we face today is the sustainable production, storage, and distribution of electrical power. One emerging technology with great promise in this area is that of metal-air fuel cells—a long-term and reusable electricity storage system made from a reactive metal anode and a saline solution. In this study the authors tested several different types of metal to determine which was the most suitable for this application. They found that a fuel cell with a magnesium anode was superior to fuel cells made from aluminum or zinc, producing a voltage and current sufficient for real-world applications such as charging a mobile phone.

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Plasmid Variance and Nutrient Regulation of Bioluminescence Genes

Uhler et al. | Dec 09, 2014

Plasmid Variance and Nutrient Regulation of Bioluminescence Genes

Numerous organisms, including the marine bacterium Aliivibrio fischeri, produce light. This bioluminescence is involved in many important symbioses and may one day be an important source of light for humans. In this study, the authors investigated ways to increase bioluminescence production from the model organism E. coli.

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A novel encoding technique to improve non-weather-based models for solar photovoltaic forecasting

Ahmed et al. | Jun 09, 2023

A novel encoding technique to improve non-weather-based models for solar photovoltaic forecasting

Several studies have applied different machine learning (ML) techniques to the area of forecasting solar photovoltaic power production. Most of these studies use weather data as inputs to predict power production; however, there are numerous practical issues with the procurement of this data. This study proposes models that do not use weather data as inputs, but rather use past power production data as a more practical substitute to weather-based models. Our proposed models demonstrate a better, cheaper, and more reliable alternatives to current weather models.

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Testing Various Synthetic and Natural Fiber Materials for Soundproofing

Karuppiah et al. | Jun 15, 2017

Testing Various Synthetic and Natural Fiber Materials for Soundproofing

Noise pollution negatively impacts the health and behavioral routines of humans and other animals, but the production of synthetic sound-absorbing materials contributes to harmful gas emissions into the atmosphere. The authors of this paper investigated the effectiveness of environmentally-friendly, cheap natural-fiber materials, such as jute, as replacements for synthetic materials, such as gypsum and foam, in soundproofing.

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Friend or Foe: Investigating the Relationship between a Corn Crop and a Native Ragweed Population

Wainwright et al. | May 07, 2014

Friend or Foe: Investigating the Relationship between a Corn Crop and a Native Ragweed Population

Farmers will need to increase crop yields to feed the world's growing population efficiently. The authors here investigate the effects of growing corn in the presence or absence of ragweed, an invasive weed found in many fields and gardens. Surprisingly, the authors found that corn grown in the presence of weeds grew taller and were more productive than corn that had weeds removed. This may help gardeners rethink the necessity of weeding, and may point a way to improve farm yields in the future.

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Buttermilk and baking soda increase pancake fluffiness by liberating carbon dioxide

Rojas et al. | Sep 18, 2022

Buttermilk and baking soda increase pancake fluffiness by liberating carbon dioxide

Here, seeking a better understanding of what determines the fluffiness of a pancake, the authors began by considering a chemical reaction that results in the production of carbon dioxide gas from recipe ingredients, specifically sodium bicarbonate or baking soda. The substitution of homemade buttermilk for milk and adding more baking soda was found to result in significantly fluffier pancakes.

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