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Assessing and Improving Machine Learning Model Predictions of Polymer Glass Transition Temperatures

Ramprasad et al. | Mar 18, 2020

Assessing and Improving Machine Learning Model Predictions of Polymer Glass Transition Temperatures

In this study, the authors test whether providing a larger dataset of glass transition temperatures (Tg) to train the machine-learning platform Polymer Genome would improve its accuracy. Polymer Genome is a machine learning based data-driven informatics platform for polymer property prediction and Tg is one property needed to design new polymers in silico. They found that training the model with their larger, curated dataset improved the algorithm's Tg, providing valuable improvements to this useful platform.

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Modeling Energy Produced by Solar Panels

Meister et al. | Jan 13, 2018

Modeling Energy Produced by Solar Panels

In this study, the authors test the effect that the tilt angle of a solar panel has on the amount of energy it generates. This investigation highlights a simple way that people can harvest renewable energy more efficiently and effectively.

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Predicting smoking status based on RNA sequencing data

Yang et al. | Aug 30, 2024

Predicting smoking status based on RNA sequencing data
Image credit: Yang and Stanley 2024

Given an association between nicotine addiction and gene expression, we hypothesized that expression of genes commonly associated with smoking status would have variable expression between smokers and non-smokers. To test whether gene expression varies between smokers and non-smokers, we analyzed two publicly-available datasets that profiled RNA gene expression from brain (nucleus accumbens) and lung tissue taken from patients identified as smokers or non-smokers. We discovered statistically significant differences in expression of dozens of genes between smokers and non-smokers. To test whether gene expression can be used to predict whether a patient is a smoker or non-smoker, we used gene expression as the training data for a logistic regression or random forest classification model. The random forest classifier trained on lung tissue data showed the most robust results, with area under curve (AUC) values consistently between 0.82 and 0.93. Both models trained on nucleus accumbens data had poorer performance, with AUC values consistently between 0.65 and 0.7 when using random forest. These results suggest gene expression can be used to predict smoking status using traditional machine learning models. Additionally, based on our random forest model, we proposed KCNJ3 and TXLNGY as two candidate markers of smoking status. These findings, coupled with other genes identified in this study, present promising avenues for advancing applications related to the genetic foundation of smoking-related characteristics.

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Investigating the inhibition of catabolic enzymes for implications in cardiovascular diseases and diabetes

Gandhi et al. | Aug 25, 2024

Investigating the inhibition of catabolic enzymes for implications in cardiovascular diseases and diabetes
Image credit: The authors

Enzymes that metabolize carbohydrates and lipids play a key role in our health, including global health challenges like cardiovascular diseases and diabetes. To learn more about these important enzymes, Gandhi and Gandhi test whether various natural substances (ginger, Aloe vera, lemon, and mint leaves) affect the activity of α-amylase and lipase enzymes.

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Using two-stage deep learning to assist the visually impaired with currency differentiation

Nachnani et al. | Jun 02, 2024

Using two-stage deep learning to assist the visually impaired with currency differentiation
Image credit: Omer Shahzad

Here, recognizing the difficulty that visually impaired people may have differentiating United States currency, the authors sought to use artificial intelligence (AI) models to identify US currencies. With a one-stage AI they reported a test accuracy of 89%, finding that multi-level deep learning models did not provide any significant advantage over a single-level AI.

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Cleaning up the world’s oceans with underwater laser imaging

Gurbuz et al. | Jul 07, 2023

Cleaning up the world’s oceans with underwater laser imaging
Image credit: Naja Bertolt Jensen

Here recognizing the growing amount of plastic waste in the oceans, the authors sought to develop and test laser imaging for the identification of waste in water. They found that while possible, limitations such as increasing depth and water turbidity result in increasing blurriness in laser images. While their image processing methods were somewhat insufficient they identified recent methods to use deep learning-based techniques as a potential avenue to viability for this method.

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