Browse Articles

A Novel Alzheimer's Disease Therapeutic Model: Attenuating Hyperphosphorylated Tau and Amyloid β (Aβ) Aggregates by Characterizing Antioxidative, Anti-Inflammatory, and Neuroprotective Properties of Natural Extracts

Pokkunuri et al. | Jul 25, 2022

A Novel Alzheimer's Disease Therapeutic Model: Attenuating Hyperphosphorylated Tau and Amyloid β (Aβ) Aggregates by Characterizing Antioxidative, Anti-Inflammatory, and Neuroprotective Properties of Natural Extracts

Oxidative damage and neuro-inflammation were the key pathways implicated in the pathogenesis of Alzheimer’s disease. In this study, 30 natural extracts from plant roots and leaves with extensive anti-inflammatory and anti-oxidative properties were consumed by Drosophila melanogaster. Several assays were performed to evaluate the efficacy of these combinational extracts on delaying the progression of Alzheimer’s disease. The experimental group showed increased motor activity, improved associative memory, and decreased lifespan decline relative to the control group.

Read More...

Estimation of Reproduction Number of Influenza in Greece using SIR Model

Skarpeti et al. | Nov 18, 2020

Estimation of Reproduction Number of Influenza in Greece using SIR Model

In this study, we developed an algorithm to estimate the contact rate and the average infectious period of influenza using a Susceptible, Infected, and Recovered (SIR) epidemic model. The parameters in this model were estimated using data on infected Greek individuals collected from the National Public Health Organization. Our model labeled influenza as an epidemic with a basic reproduction value greater than one.

Read More...

Assessing and Improving Machine Learning Model Predictions of Polymer Glass Transition Temperatures

Ramprasad et al. | Mar 18, 2020

Assessing and Improving Machine Learning Model Predictions of Polymer Glass Transition Temperatures

In this study, the authors test whether providing a larger dataset of glass transition temperatures (Tg) to train the machine-learning platform Polymer Genome would improve its accuracy. Polymer Genome is a machine learning based data-driven informatics platform for polymer property prediction and Tg is one property needed to design new polymers in silico. They found that training the model with their larger, curated dataset improved the algorithm's Tg, providing valuable improvements to this useful platform.

Read More...

Molecular Alterations in a High-Fat Mouse Model Before the Onset of Diet–Induced Nonalcoholic Fatty Liver Disease

Lee et al. | Sep 20, 2016

Molecular Alterations in a High-Fat Mouse Model Before the Onset of Diet–Induced Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases worldwide, but there are few studied warning signs for early detection of the disease. Here, researchers study alterations that occur in a mouse model of NAFLD, which indicate the onset of NAFLD sooner. Earlier detection of diseases can lead to better prevention and treatment.

Read More...

Optimizing AI-generated image detection using a Convolutional Neural Network model with Fast Fourier Transform

Gupta et al. | Oct 24, 2025

Optimizing AI-generated image detection using a Convolutional Neural Network model with Fast Fourier Transform

Recent advances in generative AI have made it increasingly hard to distinguish real images from AI-generated ones. Traditional detection models using CNNs or U-net architectures lack precision because they overlook key spatial and frequency domain details. This study introduced a hybrid model combining Convolutional Neural Networks (CNN) with Fast Fourier Transform (FFT) to better capture subtle edge and texture patterns.

Read More...

Researching the research enthusiasts: examining their motivation and the impact of a successful role model

Jubair et al. | Sep 18, 2024

Researching the research enthusiasts: examining their motivation and the impact of a successful role model
Image credit: The authors

High school and university students have various motivations for participating in research, ranging from strengthening their applications for university to building skills for a research career. Jubair and Islam survey Bangladeshi high school and university students to uncover their motivations and inspirations for participating in research.

Read More...

The impact of greenhouse gases, regions, and sectors on future temperature anomaly with the FaIR model

Kosaraju et al. | Jul 29, 2024

The impact of greenhouse gases, regions, and sectors on future temperature anomaly with the FaIR model

This study explores how different economic sectors, geographic regions, and greenhouse gas types might affect future global mean surface temperature (GMST) anomalies differently from historical patterns. Using the Finite Amplitude Impulse Response (FaIR) model and four Shared Socioeconomic Pathways (SSPs) — SSP126, SSP245, SSP370, and SSP585 — the research reveals that future contributions to GMST anomalies.

Read More...