The authors looked at four members of the tetracycline antibiotic family/class against four different species of bacteria.
Read More...Strain selective in vitro and in silico structure activity relationship of tetracycline antibiotics
The authors looked at four members of the tetracycline antibiotic family/class against four different species of bacteria.
Read More...Effects of common supplements on human platelet aggregation in vitro
There is a need for safe and effective therapies to prevent platelet aggregation associated with cardiovascular diseases. Prabhakar and Prabhakar test to see whether dietary supplements claiming to reduce cardiovascular disease risk will affect aggregation of human platelets.
Read More...Optimizing an eDNA assay and field deployment to detect decapod species in Oʻahu streams
This study explored the use of environmental DNA (eDNA) methods to detect native Hawaiian decapod species (‘opae), which are difficult to observe manually due to their low density.
Read More...Parental exposure of cannabinoids THC and CBD reduces reproductive rates in Drosophila melanogaster
The authors looked at whether CBD and THC would decrease reproductive rates in a Drosophila melanogaster model. They found that CBD had a greater impact on reducing hatching rates than THC, and that THC resulted in unexpected mortalities.
Read More...A novel approach for predicting Alzheimer’s disease using machine learning on DNA methylation in blood
Here, recognizing the difficulty associated with tracking the progression of dementia, the authors used machine learning models to predict between the presence of cognitive normalcy, mild cognitive impairment, and Alzheimer's Disease, based on blood DNA methylation levels, sex, and age. With four machine learning models and two dataset dimensionality reduction methods they achieved an accuracy of 53.33%.
Read More...Elevated levels of IL-8, TGF-β, and TNF-α associated with pneumoconiosis: A meta-analysis
The authors looked at previous studies to evaluate the ability to use serum levels of certain cytokines as biomarkers for pneumoconiosis.
Read More...Role of bacterial flagella in bacterial adhesion of Escherichia coli to glass surface
In this study, the authors investigate the effects that flagella have on E. coli's ability to adhere to glass surfaces.
Read More...A new therapy against MDR bacteria by in silico virtual screening of Pseudomonas aeruginosa LpxC inhibitors
Here, seeking to address the growing threat of multidrug-resistant bacteria (MDR). the authors used in silico virtual screening to target MDR Pseudomonas aeruginosa. They considered a key protein in its biosynthesis and virtually screened 20,000 candidates and 30 derivatives of brequinar. In the end, they identified a possible candidate with the highest degree of potential to inhibit the pathogen's lipid A synthesis.
Read More...Novel biaryl imines and amines as potential competitive inhibitors of dihydropteroate synthase
In this study, the authors design a series of new biaryl small molecules to target and block the binding pocket of the enzyme dihydropteroate synthase, which is important for prokaryotic biosynthesis of folic acid and could serve as better antimicrobial compounds.
Read More...Bacteria and Antibiotic Resistance in School Bathrooms
Since school bathrooms are widely suspected to be unsanitary, we wanted to compare the total amount of bacteria with the amount of bacteria that had ampicillin or streptomycin resistance across different school bathrooms in the Boston area. We hypothesized that because people interact with the faucet, outdoor handle, and indoor handle of the bathroom, based on whether or not they have washed their hands, there would be differences in the quantity of the bacteria presented on these surfaces. Therefore, we predicted certain surfaces of the bathroom would be less sanitary than others.
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