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Cancer is often caused by improper function of a few proteins, and sometimes it takes only a few proteins to malfunction to cause drastic changes in cells. Here the authors look at the genes that were mutated in patients with a type of pancreatic cancer to identify proteins that are important in causing cancer. They also determined which proteins currently lack effective treatment, and suggest that certain proteins (named KRAS, CDKN2A, and RBBP8) are the most important candidates for developing drugs to treat pancreatic cancer.

Life requires many things, including a hospitable temperature, elements, and energy. Here the authors utilize Newton's laws of physics and information relating a star's luminosity and temperature to determine the minimum and maximum masses and luminosities of planets and stars that would support life as we know it. This work can be used to determine the likelihood of a planet being able to support life based on attributes we can measure from here on Earth.

In many cultures and for many centuries, the implications of birth order have been examined. Birth order has been shown to affect personality, accomplishments, and even career choice. This study investigated the impact of birth order and ethnicity on two measures of academic success in high school: a student’s grade point average (GPA) and the number of Advanced Placement (AP) classes he or she took.

Here the authors investigated the impact of player ability versus starting positions in the game of Nim under imperfect play, hypothesizing that player skill becomes the primary determinant of outcomes as pile sizes grow. Through computational simulations and a mathematical model, they demonstrated that favorable starting positions lose their advantage over time and provide key insights to help improve reinforcement learning algorithms in abstract, complex decision-making environments.

Content warning: This article discusses the frequency and impact of mass violence incidents, particularly school shootings. Gun violence, threats of gun violence, firearm supply, fatalities among minors, and bullying are discussed but not graphically described.

This study examines how environmental conditions influence the abundance and ecological role of the sea cucumber Opheodesoma spectabilis in Kāneʻohe Bay. Field observations and laboratory experiments showed that the species is more common in algae-dominated sandy habitats, where it improves water clarity and increases dissolved oxygen through bioturbation. However, exposure to very high temperatures caused rapid mortality, suggesting that marine heat waves could threaten this species and the ecological functions it provides.

The authors studied the ability of freshwater clams to improve water quality.

The authors studied bacterial contamination of the New York City transit system, as well as the effectiveness of hand washing and hand sanitizer.

Tax incentives for sustainable technology are a key part of the push for a greener future. However, these incentives may not reach all income strata equally. Using a machine learning approach, this study analyzed the distributional effects of residential energy tax credits across different income levels in the United States.

This manuscript tackles a major social issue in the health news sector, with social media being one of the primary sources of information and a prime spot to propagate fake news. The author proposes X-HND , which is a unique architecture that combines emotional and contextual analysis in a Graph Neural Network to accurately detect fake news. This was a multi-step process which involved the creation of a custom health news dataset (HNDataset), and an emotional variant that uses RoBERTa to extract emotion. These dataset were then used to prove the hypothesis that accuracy increases when the custom dataset is used to train the model and that with the integration of emotion capture, the detection accuracy increases further.