The authors used RNA-seq datasets to assess the effect of CDK7 inhibition on transcriptional pathways in castration-resistant prostate cancer cells.
Read More...CDK7 inhibition disrupts androgen signaling and induces metabolic rewiring in prostate cancer cells
The authors used RNA-seq datasets to assess the effect of CDK7 inhibition on transcriptional pathways in castration-resistant prostate cancer cells.
Read More...The impact of light pollution on astrophotography and visual astronomy in varying environments
VISTA inhibitor CA170 combined with KRAS vaccine enhances immune response in lung cancer
Here the authors investigated a combination therapy to target the Kirsten rat sarcoma viral oncogene homolog mutation in lung cancer, by analyzing publicly available data. Their findings indicate that the combination therapy of CA170 and Kvax enhances helper T cell function and improves cytotoxic T lymphocyte infiltration, while Kvax alone drives plasma and memory B cell proliferation.
Read More...Investigating toxicity and antimicrobial properties of silver nanoparticles in Escherichia coli and Drosophila melanogaster
This paper looks at the antibacterial and toxic effects of silver nanoparticles (AgNPs) on Escherichia coli bacteria and Drosophila melanogaster fruit flies. They modified the AgNPs size, concentration, and surface coating to determine the effects on each of the organisms. For both organisms, increased AgNP concentration demonstrated increased toxicity but particle size and surface coating had opposing effects.
Read More...C reactive protein and risk of neurological deficits and disability in patients with acute ischemic stroke
The authors looked at the correlation between C reactive protein levels and neurological deficits in patients who had suffered an ischemic stroke.
Read More...Novel anticancer effects of melatonin and berberine via signaling pathways in colorectal cancer and lymphoma
The authors looked at the ability of berberine in combination with melatonin to have anticancer effects when tested in an in vitro cell model.
Read More...India’s digital public infrastructure: Analyzing UPI and Aadhaar in GDP growth and cost optimization
India’s Digital Public Infrastructure (DPI)—including the Unified Payments Interface (UPI) and Aadhaar—has been globally recognized for advancing financial inclusion and efficient governance. This study analyzes data from 2016–17 to 2023–24 the impact of these services on India's GDP.
Read More...Ultraviolet exposure and thermal mass variation on surface temperature responses in building materials
The authors studied the response of various construction materials to UV solar radiation and heat.
Read More...The effects of dysregulated ion channels and vasoconstriction in glioblastoma multiforme
Impact of TCERG1 SNP on gene expression and protein interactome in Huntington’s disease
The authors assess a genetic variant within a well-known interaction partner of huntingtin that has been linked to modifying the age of onset of Huntington's disease.
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