The authors looked at the potential of different phenolic compounds to reduce oxidative stress (i.e., act as antioxidants).
Read More...The effect of natural phenolic compounds on reducing oxidative stress
The authors looked at the potential of different phenolic compounds to reduce oxidative stress (i.e., act as antioxidants).
Read More...De novo design of a dual-target inhibitor against tau phosphorylation and acetylation for Alzheimer's therapy
The authors use computational methods to compare tau acetylation to the better studied tau phosphorylation in Alzheimer's disease and then design and computationally test a new drug to prevent abnormal post-translational modifications of tau.
Read More...CDK7 inhibition disrupts androgen signaling and induces metabolic rewiring in prostate cancer cells
The authors used RNA-seq datasets to assess the effect of CDK7 inhibition on transcriptional pathways in castration-resistant prostate cancer cells.
Read More...VISTA inhibitor CA170 combined with KRAS vaccine enhances immune response in lung cancer
Here the authors investigated a combination therapy to target the Kirsten rat sarcoma viral oncogene homolog mutation in lung cancer, by analyzing publicly available data. Their findings indicate that the combination therapy of CA170 and Kvax enhances helper T cell function and improves cytotoxic T lymphocyte infiltration, while Kvax alone drives plasma and memory B cell proliferation.
Read More...Assessing machine learning model efficacy for brain tumor MRI classification: a multi-model approach
This manuscript explores the performance of five different machine learning models in classifying brain tumors from a dataset of MRI scans. The authors find that several of the models showed >90% accuracy. Thus, the authors suggest that machine learning models demonstrate potential for effective implementation in clinical settings, including as a diagnostic tool that can be used to complement the expertise of neuroradiologists.
Read More...Exotropia detection using computer vision, image processing and facial landmark detection
The authors looked at using computer vision to evaluate the degree of exotropia in individuals with strabismus.
Read More...Optimizing Arthrospira platensis growth for biofuel production via symbiosis between cyanobacteria strains
The authors test symbiotic relationships among cyanobacteria species to generate more robust cultures for potential biofuel production.
Read More...Rethinking the electric vehicle tax policy: prioritizing affordable solutions for environmental impact
Car emissions harm both the environment and human health, and current U.S. EV tax credits mainly benefit high-income households because EVs are expensive. This study evaluates U.S. vehicle emissions policies by analyzing 2022 national vehicle data to compare the fuel economy and greenhouse gas impacts of the current EV tax credit with a proposed policy that incentivizes hybrid vehicle purchases.
Read More...In silico design of novel acetylcholinesterase inhibitors as potential therapeutics for Alzheimer's disease
Elevated acetylcholinesterase (AChE) activity contributes to cognitive decline and neurodegenerative diseases such as Alzheimer’s, motivating the search for more effective inhibitors with better bioavailability. This study used computational methods to design novel, non-toxic AChE inhibitors.
Read More...Student work preferences: Typing or handwriting in the digital era
The authors survey high school students regarding preferences for taking notes by hand versus typing.
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