The authors test the effectiveness of machine learning to predict onset of cardiovascular disease.
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Comparing the effects of electronic cigarette smoke and conventional cigarette smoke on lung cancer viability
Here, recognizing the significant growth of electronic cigarettes in recent years, the authors sought to test a hypothesis that three main components of the liquid solutions used in e-cigarettes might affect lung cancer cell viability. In a study performed by exposing A549 cells, human lung cancer cells, to different types of smoke extracts, the authors found that increasing levels of nicotine resulted in improve lung cancer cell viability up until the toxicity of nicotine resulted in cell death. They conclude that these results suggest that contrary to conventional thought e-cigarettes may be more dangerous than tobacco cigarettes in certain contexts.
Read More...Effect of Fertilizer on Water Quality of Creeks over Time
Fertilizers are commonly used to improve agricultural yield. Unfortunately, chemical fertilizers can seep into drinking water, potentially harming humans and other forms of life. Here, the authors investigate the effect of fertilizer on the water quality of Saratoga Creek over time. They find that fertilizers can alter the acidity of the creek's water, which can be harmful to aquatic species, as well as increase the levels of nitrates temporarily.
Read More...The Effect of Poverty on Mosquito-borne Illness Across the United States
Mosquito-borne diseases are a major issue across the world, and the objective for this project was to determine the characteristics that make some communities more susceptible to these diseases than others. The authors identified and studied characteristics that make communities susceptible to mosquito-borne diseases, including water in square miles, average temperature, population, population density, and poverty rates per county. They found that the population of a county is the best indicator of the prevalence of mosquito-borne diseases.
Read More...High school students show some reluctance to COVID-19 guidelines
COVID-19 has officially been downgraded from the status of a global health emergency, but have COVID-19 safety practices become a new way of life for students? The authors collected survey data on COVID-19-related knowledge and behaviors of high-school students in Punjab, Pakistan and Santa Clara County, California, USA, so see where high-schoolers stand on pandemic safety today.
Read More...High school students’ attitudes towards diverse cultures and ethnicities
The authors looked at how a student's own background influence their attitude towards integration of diverse cultures and ethnicities. While overall students viewed other groups positively, the authors found that groups still indicated they felt judged by their peers.
Read More...High-throughput virtual screening of novel dihydropyrimidine monastrol analogs reveals robust structure-activity relationship to kinesin Eg5 binding thermodynamics
As cancer continues to take millions of lives worldwide, the need to create effective therapeutics for the disease persists. The kinesin Eg5 assembly motor protein is a promising target for cancer therapeutics as inhibition of this protein leads to cell cycle arrest. Monastrol, a small dihydropyrimidine-based molecule capable of inhibiting the kinesin Eg5 function, has attracted the attention of medicinal chemists with its potency, affinity, and specificity to the highly targeted loop5/α2/α3 allosteric binding pocket. In this work, we employed high-throughput virtual screening (HTVS) to identify potential small molecule Eg5 inhibitors from a designed set of novel dihydropyrimidine analogs structurally similar to monastrol.
Read More...Molecular Alterations in a High-Fat Mouse Model Before the Onset of Diet–Induced Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases worldwide, but there are few studied warning signs for early detection of the disease. Here, researchers study alterations that occur in a mouse model of NAFLD, which indicate the onset of NAFLD sooner. Earlier detection of diseases can lead to better prevention and treatment.
Read More...Motivation’s impact on high-level high school students’ ability to balance academic and athletic stress
The authors looked at the relation between stress and motivation in high school students with 4+ AP classes that also played a varsity sport. No distinct correlation was observed, however, results indicated that there are other factors at play that influence both stress and motivation.
Read More...Locating sources of a high energy cosmic ray extensive air shower using HiSPARC data
Using the data provided by the University of Twente High School Project on Astrophysics Research with Cosmics (HiSPARC), an analysis of locations for possible high-energy cosmic ray air showers was conducted. An example includes an analysis conducted of the high-energy rain shower recorded in January 2014 and the use of Stellarium™ to discern its location.
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